The role of melatonin on acute thyroid damage induced by high dose rate X-ray in head and neck radiotherapy

Aras, Serhat; Tanzer, İhsan Oğuz; Can, Unal; Sümer, Engin; Baydili, Kürşad Nuri

doi:10.1016/j.radphyschem.2020.109206

Cited by 10 publications

(2 citation statements)

References 36 publications

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“…Kim et al [ 30 ] and Mullur et al [ 31 ] indicated that L-thyroxine boosted thyroid gland activity via diminishing the oxidative iodination within the gland thus perturbing the production and release of the thyroid hormones. Moreover, it was found that thyroid damage derived from radiation was attributed to its high sensitivity to radiation [ 32 ] leading to follicular disruption, thrombosis and degeneration of the vascular system due to inflammation, partial epithelial regeneration and cellular fibrosis and necrosis [ 33 , 34 ]. Meanwhile, it was found that treatment with MO Extract maintained the thyroid function by reversing the effect of Elt.+IR on the thyroid gland.…”

Section: Discussionmentioning

confidence: 99%

Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats

Kawara,

Moawed,

Elsenosi

et al. 2024

BMC Complement Med Ther

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Background Melissa officinalis (MO) is a well-known medicinal plant species used in the treatment of several diseases; it is widely used as a vegetable, adding flavour to dishes. This study was designed to evaluate the therapeutic effect of MO Extract against hyperthyroidism induced by Eltroxin and γ-radiation. Methods Hyperthyroidism was induced by injecting rats with Eltroxin (100 µg/kg/ day) for 14 days and exposure to γ-radiation (IR) (5 Gy single dose). The hyperthyroid rats were orally treated with MO extract (75 mg/kg/day) at the beginning of the second week of the Eltroxin injection and continued for another week. The levels of thyroid hormones, liver enzymes and proteins besides the impaired hepatic redox status and antioxidant parameters were measured using commercial kits. The hepatic gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its inhibitor Kelch-like ECH-associated protein-1(Keap-1) in addition to hepatic inflammatory mediators including tumor necrosis factor-α (TNF- α), Monocyte chemoattractant protein-1 (MCP-1) and fibrogenic markers such as transforming growth factor-beta1 (TGF-β1) were determined. Results MO Extract reversed the effect of Eltroxin + IR on rats and attenuated the thyroid hormones. Moreover, it alleviated hyperthyroidism-induced hepatic damage by inhibiting the hepatic enzymes’ activities as well as enhancing the production of proteins concomitant with improving cellular redox homeostasis by attenuating the deranged redox balance and modulating the Nrf2/Keap-1 pathway. Additionally, MO Extract alleviated the inflammatory response by suppressing the TNF- α and MCP-1 and prevented hepatic fibrosis via Nrf2-mediated inhibition of the TGF-β1/Smad pathway. Conclusion Accordingly, these results might strengthen the hepatoprotective effect of MO Extract in a rat model of hyperthyroidism by regulating the Nrf-2/ Keap-1 pathway.

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Section: Discussionmentioning

confidence: 99%

Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats

Kawara,

Moawed,

Elsenosi

et al. 2024

BMC Complement Med Ther

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“…Besides the aforementioned characteristics, MTN has a crucial role in regulating human reproduction processes, such as oocyte quality, folliculogenesis, oocyte maturation, embryo implantation, fetal development, and the outcomes of pregnancy. Therefore, the idea of MTN utilization in the therapeutic approaches of reproductive and gestational disorders seems favorable to some authorities 20,21 . The low MTN levels in elderly people are correlated with reproductive aging and high gonadotropin secretion, while menopause is characterized by the inability of the ovaries to produce viable follicles and hormonal changes, which leads to menstrual cycle failures.…”

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confidence: 99%

Melatonin, menopause, and thyroid function in gynecologic endocrinology: what is the role?

Soares Junior,

Detanac,

Sengul

et al. 2024

Rev. Assoc. Med. Bras.

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Melatonin (MTN), a neurohormone primarily synthesized and secreted mainly by the pine cone-shaped gland of the cerebrum, named as the conarium or epiphysis cerebri, from amino acid tryptophan, was first isolated from the bovine pineal gland by Lerner et al 1 . However, the 17th-century philosopher René Descartes hypothesized that the pineal gland of the brain, which remains poorly understood to date, represents the location of the homo sapiens soul; paleontologists described it as an ancestral "third eye"; and modern psychology declares perception beyond physical visual function 2,3 . This chemical messenger, per se, ensures high precision in the reconnoitering of the night period, is an endocrine marker for darkness, and participates in the regulation of circadian rhythm and the sleep-wake cycle. Of note, MTN can be produced by other organs, such as the brain, lungs, gastrointestinal tract, liver, thyroid, and reproductive and immune systems, and is present in mucus, saliva, breast milk, urine, sperm, amniotic fluid, Graafian follicle, etc. 1,4-9 . As such, various studies have shown that MTN affects many functions in the body and acts on different tissues, and some of its properties include significant antioxidant, anti-inflammatory, antiproliferative, and immunomodulatory capacity. MTN, per se, can directly neutralize toxic free radicals more effectively, suppresses chronic oxidative stress, has a significant impact on reproductive cells, enhances the quality of sperm and oocytes, has oncostatic and antitumoral cytoprotective effects 10,11 , alleviates some of the undesirable toxic effects of radiotherapy and chemotherapy by increasing the tolerance of healthy tissues, compared to other antioxidants, by stimulating responses to DNA damage. To this

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Radiation sensitivity of biological systems, its modification by chemical modifiers and its quantitative evaluation

Múčka,

Čuba

2024

J Radioanal Nucl Chem

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Large number of sensitizers and protectors of cells, tissues, organs and organisms are being discussed in this review. Attention is paid to metals, nanoparticles or organic compounds as modifiers. They can modify the radiation sensitivity by 20–60%. In most cases, sensitization is caused by an increase in DNA damage or a decrease in the repair of radiation damage. The protection can be caused in many cases by repair of damaged DNA molecules, proteins or enzymes, or by reducing the ROS concentration. The most current research tasks in this area are formulated. A new quantitative and reproducible method of evaluating modifiers is discussed.

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The role of melatonin on acute thyroid damage induced by high dose rate X-ray in head and neck radiotherapy

Cited by 10 publications

References 36 publications

Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats

Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats

Melatonin, menopause, and thyroid function in gynecologic endocrinology: what is the role?

Radiation sensitivity of biological systems, its modification by chemical modifiers and its quantitative evaluation

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