The role of mediodorsal thalamic nucleus in fear extinction

Lee, Sukchan; Shin, Hee‐Sup

doi:10.1186/s40543-016-0093-6

Cited by 19 publications

(11 citation statements)

References 64 publications

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“…This indicates the existence of a functional connectivity between thalamus and distinct clusters of cortical neurons [107]. Taking all of the above into consideration, it was suggested that the communication between the mediodorsal thalamus and the cortex is fundamental for fear extinction also, since attention is needed to decrease the unpleasant thoughts and the intensity of the feelings [108].…”

Section: Mediodorsal Thalamus Neuromodulationmentioning

confidence: 99%

The Anatomical and Functional Heterogeneity of the Mediodorsal Thalamus

2020

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The mediodorsal nucleus (MD) represents just one piece of a complex relay structure situated within the brain, called the thalamus. MD is characterized by its robust interconnections with other brain areas, especially with limbic-related structures. Given the close anatomo-functional relationship between the MD and the limbic system, this particular thalamic nucleus can directly influence various affective behaviors and participate in cognition. In this work, we review data collected from multiple anatomical studies conducted in rodent, human, and non-human primates, highlighting the complexity of this structure and of the neural networks in which it takes part. We provide proof that the MD is involved in the unification of several anatomical structures, being able to process the information and influence the activity in numerous cortical and subcortical neural circuits. Moreover, we uncover intrinsic and extrinsic mechanisms that offer MD the possibility to execute and control specific high functions of the nervous system. The collected data indicate the great importance of the MD in the limbic system and offer relevant insight into the organization of thalamic circuits that support MD functions.

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Section: Mediodorsal Thalamus Neuromodulationmentioning

confidence: 99%

The Anatomical and Functional Heterogeneity of the Mediodorsal Thalamus

2020

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“…The MDT is being increasingly recognized as a potential target for MDD treatment since it seemingly presents a higher order thalamic relay, making it relevant for learning, decision‐making, social behaviour and fear extinction (Lee & Shin, 2016; Mitchell, 2015). In a study by Carlson et al (2017), mice were subjected to TST.…”

Section: Optogenetic and Chemogenetic Findings On The Neurocircuitry mentioning

confidence: 99%

Optogenetic and chemogenetic insights into the neurocircuitry of depression‐like behaviour: A systematic review

Biselli

Lange

Sablottny

et al. 2019

Eur J of Neuroscience

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Major depressive disorder (MDD) and its treatment are challenges for global health. Optogenetics and chemogenetics are driving MDD research forward by unveiling causal relations between cell type-specific control of neurons and depressive-like behaviour in rodents. Using a systematic search process, in this review, a set of 43 original studies applying optogenetic or chemogenetic techniques in rodent models of depression was identified. Our aim was to provide an examination of all available studies elucidating central neuronal mechanisms leading to depressive-like behaviour in rodents and thereby unveiling the most promising routes for future research. A complex interacting network of relevant structures, in which central circuitries causally related to depressive-like behaviour are implicated, has been identified. As most relevant structures emerge: medial prefrontal cortex, anterior cingulate cortex, amygdala, nucleus accumbens, ventral tegmental area, hippocampus and raphe nuclei. Further evidence, though examined by only few studies, emerges for structures like the lateral habenula, or medial dorsal thalamus. Most of the identified brain areas have previously been associated with MDD neuropathology, but now evidence can be provided for causal pathological mechanisms within a complex cortico-limbic reward circuitry. However, the studies also show conflicting results concerning the 10 |

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“…Due to the functional similarity, TS-PCM can emulate various forms of neuronal spiking behavior like tonic spiking and bursting, as demonstrated in Fig. 3b-e [49][50][51] . Tonic spiking mode, a series of single spike firing, is known to be involved in working memory, fear extinction, and visual information processing.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous emulation of synaptic and intrinsic plasticity using a memristive synapse

et al. 2022

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Neuromorphic computing targets the hardware embodiment of neural network, and device implementation of individual neuron and synapse has attracted considerable attention. The emulation of synaptic plasticity has shown promising results after the advent of memristors. However, neuronal intrinsic plasticity, which involves in learning process through interactions with synaptic plasticity, has been rarely demonstrated. Synaptic and intrinsic plasticity occur concomitantly in learning process, suggesting the need of the simultaneous implementation. Here, we report a neurosynaptic device that mimics synaptic and intrinsic plasticity concomitantly in a single cell. Threshold switch and phase change memory are merged in threshold switch-phase change memory device. Neuronal intrinsic plasticity is demonstrated based on bottom threshold switch layer, which resembles the modulation of firing frequency in biological neuron. Synaptic plasticity is also introduced through the nonvolatile switching of top phase change layer. Intrinsic and synaptic plasticity are simultaneously emulated in a single cell to establish the positive feedback between them. A positive feedback learning loop which mimics the retraining process in biological system is implemented in threshold switch-phase change memory array for accelerated training.

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The role of mediodorsal thalamic nucleus in fear extinction

Cited by 19 publications

References 64 publications

The Anatomical and Functional Heterogeneity of the Mediodorsal Thalamus

The Anatomical and Functional Heterogeneity of the Mediodorsal Thalamus

Optogenetic and chemogenetic insights into the neurocircuitry of depression‐like behaviour: A systematic review

Simultaneous emulation of synaptic and intrinsic plasticity using a memristive synapse

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