The role of mediator complex subunit 19 in human diseases

Abstract

Mediator is an evolutionarily conserved multi-protein complex that mediates the interaction between different proteins as a basic linker in the transcription mechanism of eukaryotes. It interacts with RNA polymerase II and participates in the process of gene expression. Mediator complex subunit 19 or regulation by oxygen 3, or lung cancer metastasis-related protein 1 is located at the head of the mediator complex; it is a multi-protein co-activator that induces the transcription of RNA polymerase II by DNA transcription factors. It is a tumor-related gene that plays an important role in transcriptional regulation, cell proliferation, and apoptosis and is closely related to the occurrence and development of the cancers of the lung, bladder, skin, etc. Here, we used the structure of mediator complex subunit 19 to review its role in tumor progression, fat metabolism, drug therapy, as well as the novel coronavirus, which has attracted much attention at present, suggesting that mediator complex subunit 19 has broad application in the occurrence and development of clinical diseases. As a tumor-related gene, the role and mechanism of mediator complex subunit 19 in the regulation of tumor growth could be of great significance for the diagnosis, prognosis, and treatment of mediator complex subunit 19 -related tumors.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

“…4d , e and 5c, d ). MED19 is a subunit of Mediator complex that plays critical role during transcription control 42 while MMACHC is postulated to be involved in cobalamin (vitamin B12) trafficking 43 . In parallel, we also derived oxaliplatin-resistant HCT116 cells and irinotecan-resistant DLD1 cells by gradual drug adaptation and “randomly” clonal selection, which took around three months to achieve a comparable resistance level to that of the above specific gene-derived resistant lines (Fig.…”

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

“…3d,e; S4d,e and S5c,d). MED19 is a subunit of Mediator complex that plays critical role during transcription control 42 while MMACHC is postulated to be involved in cobalamin (vitamin B12) trafficking 43 . In parallel, we also derived oxaliplatin-resistant HCT116 cells and irinotecan-resistant DLD1 cells by gradual drug adaptation and "randomly" clonal selection, which took around three months to achieve a comparable resistance level to that of above specific gene-derived resistant lines (Fig.…”

Systematic analysis of the expression profiles and prognostic significance of the MED gene family in renal clear cell carcinoma

“…The mediator complex (MED) gene family forms a multiprotein complex that connects transcription factors to RNA polymerase II, which extensively participates in the proliferation, differentiation and migration of cells ( 6 ). Notably, the MED is a protein complex that has evolved to mediate specific protein-protein interactions (PPIs) ( 7 ).…”