The role of mediastinoscopy in the diagnosis of non-lung cancer diseases

Onat, Serdar; Ateş, Güngör; Avcı, Akkan; Yıldız, Tekin; Bırak, Ali; Özmen, Cihan Akgül; Ülkü, Refık

doi:10.2147/tcrm.s144393

Cited by 18 publications

(13 citation statements)

References 31 publications

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“…Lung cancer has become a major public health challenge due to its high incidence and mortality (15). Among all lung cancer cases, NSCLC accounts for ~85% (1).…”

Section: Discussionmentioning

confidence: 99%

miR‑671‑3p is downregulated in non‑small cell lung cancer and inhibits cancer progression by directly targeting CCND2

Yao

Zhou

2019

Mol Med Report

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MicroRNAs (miRNAs) are implicated in the development and progression of non-small cell lung cancer (NSCLC). A previous study suggested that miR-671-3p suppresses the development of breast cancer. However, the role of miR-671-3p in NSCLC remains largely unknown. In the present study, it was identified that miR-671-3p was significantly upregulated in NSCLC tissues compared with adjacent normal tissues by reverse transcription quantitative polymerase chain reaction (RT-qPCR). Similarly, decreased levels of miR-671-3p in NSCLC cell lines were observed compared with those in the non-tumorigenic human bronchial epithelial NL20 cell line. Cell Counting Kit-8 and Transwell invasion assays indicated that miR-671-3p overexpression suppressed the proliferation and invasion of A549 cells, and vice versa. Mechanistically, it was demonstrated that CCND2 was a direct target of miR-671-3p. RT-qPCR and western blot analysis indicated that miR-671-3p overexpression decreased the expression of CCND2 in A549 cells. Furthermore, rescue experiments demonstrated that the restoration of CCND2 may significantly reverse the suppressive roles of miR-671-3p overexpression on NSCLC cell proliferation and invasion. Taken together, the present study demonstrated that miR-671-3p exerted its tumor-suppressive roles via directly targeting CCND2 in NSCLC.

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“…Lung cancer has become a major public health challenge due to its high incidence and mortality (15). Among all lung cancer cases, NSCLC accounts for ~85% (1).…”

Section: Discussionmentioning

confidence: 99%

miR‑671‑3p is downregulated in non‑small cell lung cancer and inhibits cancer progression by directly targeting CCND2

Yao

Zhou

2019

Mol Med Report

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“…Among presented diagnostic methods they are mostly challenging for the patients. The mediastinoscopy can reach upper retrosternal space, the trachea, and surrounding and subcarinal regions using the cervical approach 12 . Modifications such as parasternal mediastinoscopy, or using subxiphoid approach are performed in particular cases.…”

Section: Discussionmentioning

confidence: 99%

CT-guided biopsy of the mediastinal masses. Can anatomical relationships predict complications?

et al. 2019

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Aim. To retrospectively evaluate the technical features, feasibility, efficacy, accuracy and appropriate complications of CT-guided biopsies of mediastinal masses and correlate them with anatomical relationships in the mediastinum. Methods. Over the course of ten years, 81 percutaneous biopsy procedures in 78 patients for tumors sizes 27 -189 mm in diameter (median length 57.5 mm) were performed using only local anesthesia. These interventions were done under the guidance of computed tomography. The patients were men in 30 cases and women in 48 cases, aged 19 to 90 years. Results. In 78 cases (96.3%) results were either true positive or true negative; in only 3 cases (3.7%, 3 biopsies of 2 tumors in 2 patients) were histological findings false negative. In 2.3% of the patients, complications were revealed in the anterior part of the mediastinum, 43.7% occurred in the middle region, and 14.3% in the posterior region of the mediastinum. Statistical data analysis verified there was a 3.74 times chance of an increase in complications in the middle mediastinal section in correlation with other anatomical localizations. In only one case was therapeutic intervention for complication necessary. For all other cases, a conservative approach was suitable. Conclusion. Percutaneous CT guided biopsies of the mediastinal tumors has a high accuracy rate in establishing the correct diagnosis. Masses in the middle mediastinum are associated with statistically higher incidences of postprocedural complications, which are not serious.

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“…Onat et al reported the safety of CM and demonstrated that it is a reliable method, in the evaluation of mediastinal lymphadenopathy [37]. In a meta-analysis by Agarwal et al, they reported a diagnostic yield between 82 and 97% for cervical mediastinoscopy [38].…”

Section: Cervical Mediastinoscopymentioning

confidence: 99%

Current Diagnostic Techniques in Sarcoidosis

Anandavelu¹,

Fahim²

2020

Sarcoidosis and Granulomatosis - Diagnosis and Management

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Sarcoidosis is an enigmatic disorder with a propensity for lung involvement in the majority of cases (~90%) and is characterized by noncaseating granulomatous inflammation on histological analysis. The techniques to establish the diagnosis have evolved over time, and a clear diagnostic algorithm for the clinicians dealing with this disease is desirable. Thoracic computed tomography is the imaging modality of choice in pulmonary sarcoidosis and provides accurate assessment of staging, parenchymal involvement, and response to immunomodulatory therapies. The advent of EBUS-TBNA has been a step forward with an excellent diagnostic yield in the presence of mediastinal/hilar lymphadenopathy and has replaced the traditional approach of obtaining biopsy samples via transbronchial and endobronchial routes. The preferred initial investigation for the confirmation of diagnosis is dependent on the organ involvement and the expertise available. A core biopsy of cervical lymph nodes is a less invasive and economical alternative in selected cases of suspected pulmonary sarcoidosis and warrants further evaluation in prospective manner to establish if it can be considered as a first-line investigation in all new cases suspected to have pulmonary sarcoidosis. A multidisciplinary approach is crucial for the diagnosis and management, and a simplified algorithm is proposed to help guide clinicians dealing with this disease of myriad clinical and radiological manifestations.

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The role of mediastinoscopy in the diagnosis of non-lung cancer diseases

Cited by 18 publications

References 31 publications

miR‑671‑3p is downregulated in non‑small cell lung cancer and inhibits cancer progression by directly targeting CCND2

miR‑671‑3p is downregulated in non‑small cell lung cancer and inhibits cancer progression by directly targeting CCND2

CT-guided biopsy of the mediastinal masses. Can anatomical relationships predict complications?

Current Diagnostic Techniques in Sarcoidosis

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