The role of measurement uncertainty in the conformity assessment of the chemical composition of feeds

Molognoni, Luciano; Ploêncio, Leandro Antunes de Sá; Machado, Antonio Marcelo Lemos; Daguer, Heitor

doi:10.1016/j.microc.2016.11.014

Cited by 10 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Validation studies were carried out with the needed number of experiments to express the data reliability. However, as routine analyzes were continuously performed, the method was becoming more and more precise, with the increase in the number of measurements (degrees of freedom as a result of the decrease of the uncertainties arising from random effects) . Broadly speaking, the results obtained from validation and routine analysis have demonstrated that the method has the aimed metrologic reliability (Table ).…”

Section: Resultsmentioning

confidence: 99%

Cost-Effective and High-Reliability Analytical Approach for Multitoxin Screening in Bivalve Mollusks by Liquid Chromatography Coupled to Tandem Mass Spectrometry

Molognoni

Santos

Kleemann

et al. 2019

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

A fast, less expensive, analytical approach with high metrologic reliability was developed to assist an official program for 21 marine biotoxins, monitoring in bivalve mollusks. The simultaneous analysis of lipophilic and hydrophilic marine biotoxins was achieved using a sample preparation protocol based on solid–liquid extraction and low-temperature cleanup, followed by liquid chromatography coupled to tandem mass spectrometry. Samples were extracted with acidified methanol/water (90:10), followed by low-temperature cleanup. Chromatographic separation was obtained using a cyano-bonded silica phase. The mobile phase was composed of water and acetonitrile, with both 0.1% formic acid and 2.5 mmol L–1 ammonium formate. Electrospray ionization was used in both negative and positive modes. The single-laboratory validation approach enabled method performance assessment, and the necessary data to design a model for result expression were yielded. With this purpose, a systematic study of errors and uncertainties was performed. This new analytical approach aimed to minimize the use of highly expensive analytical standards, promoting economic viability to be applied by high-throughput routine laboratories. After its implementation on the Brazilian official monitoring program, positive results near the regulatory limits were obtained, demonstrating the fit for purpose of the method as a surveillance tool.

show abstract

Section: Resultsmentioning

confidence: 99%

Cost-Effective and High-Reliability Analytical Approach for Multitoxin Screening in Bivalve Mollusks by Liquid Chromatography Coupled to Tandem Mass Spectrometry

Molognoni

Santos

Kleemann

et al. 2019

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the other hand, the correct interpretation of the analytical results is fundamental because it will support important decision making, either by quality control and government agencies. Impacting consequences, such as the recall of products, destruction of large batches, application of fines, administrative and judicial proceedings, and damages to both human and animal health are some of the examples (Molognoni, Ploêncio, Machado, & Daguer, 2017). In addition, economic sanctions and barriers to international food trade have been based on the often-poor chemical metrology of some producing countries.…”

Section: Analytical Performance and Decision-makingmentioning

confidence: 99%

“…Type A uncertainty sources experimentally obtained during validation approaches, such as precision, bias, and residues from analytical curves, among others, may be initially overestimated. On the other hand, these values serve as a basis for the improvement of measuring quality, because they tend to decrease, while the number of measurements increases due to routine analysis (Molognoni et al, 2017). Furthermore, the use of internal standardization can decrease the biggest sources of uncertainty, such as random effects due to analysts and equipment which can take place in long analytical processes with (Molognoni, Valese, Lorenzetti, Daguer, & Lindner, 2016).…”

Section: Analytical Performance and Decision-makingmentioning

confidence: 99%

Current research, regulation, risk, analytical methods and monitoring results for nicarbazin in chicken meat: A perspective review

Bacila

Feddern

Igarashi‐Mafra

et al. 2017

Food Research International

Self Cite

View full text Add to dashboard Cite

This review presents up-to-date information about current research on nicarbazin, one of the most used anticoccidials in poultry production. The focus is to elucidate regulation concerning nicarbazin, limits for its residues in food, how maximum residue limits in different countries are calculated regarding edible chicken tissues and the possible implications in human health. Analytical methods to extract and quantify this residue, expressed as dinitrocarbanilide (DNC) are presented and discussed, including qualitative screening and quantitative/confirmatory analytical methods. Monitoring results and occurrence of DNC residues in chicken meat are discussed. Additionally, the causes of eventual chicken meat contamination and possible solutions to reduce or eliminate DNC residue in tissues are also presented. The paper concludes with perspectives, the current state of DNC residue analysis and suggestions for future research, especially considering the gap in the study of residue recycling effect due to continuous chicken litter use.

show abstract

“…aluminosilicate) which are not digested but bind toxic metabolites and mitotoxines secreted by undesired microorganisms which, as a result, go through a digestive tract in the unchanged form and are egested with feces without any detrimental influence on the animal body -antioxidants, -other different food products (Matuszek 2012, Zawiślak et al, 2011Molognoni et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Improvement Possibilities of Physical Properties of Mineral Fodder Additives

Sobczak

Zawiślak

Mazur

et al. 2017

Agricultural Engineering

View full text Add to dashboard Cite

The paper presents a change in physical properties of loose, dust fodder additives (aluminosilicate) after mixing them with oil or glycerine. Additives where mixed in a blade mixer with the same mixing time for all samples, which was 1 minute. Tests with oil or glycerine were carried out in the following amounts: 5%, 10%. For mixtures of additives with oil or glycerine a selected group of physical properties was determined. Method of determination of physical properties was the same for all samples i.e. the same additives − without oil and glycerine as well as mixtures with their participation. Obtained research results and their analysis unanimously indicate that adding any amount of oil or glycerine for additives improves selected physical properties of mixtures. Key words: mixing, physical properties, fodder additives, fodder IntroductionMixing is an essential stage in the industrial production of fodder mixtures. Blade mixers or band mixers for which producer states theoretical time of indispensable mixing of raw materials are the most often used. However, the mixing time depends on physical properties of mixed raw material and the time given by a producer of a mixer should be corrected after the tests on mixing uniformity (Laurent et al., 2002). Homogeneity of a mixture is checked, inter alia, with microindexes namely with iron filings (Zawiślak et al., 2012, Kró-lczyk et al., 2005, 2008. Standard ADAE (no.S303) describes the procedure of operation (Siiriä and Yliruusi, 2009, Zawiślak et al., 2011).Fodder additive means various substances used in feeding animals as supplementation of basic nutrients, vitamins and mineral compounds. Fodder additives favourably influence generally understood health of animals and improve functioning of their organisms leading to faster and efficient increase of muscle and fat tissue. Their presence in the feed dose increases productivity, improves the fodder quality (image, taste, smell, consistency, shell life) (Grochowicz and Walczyński, 2004, Heidenreich and Strauch, 2000, Putier 2001.The following are the most often used fodder additives: -probiotics, -fodder enzymes, -aromatic and taste additives, -dyes, -preservatives, -detoxification -substances including an active group (e.g. aluminosilicate) which are not digested but bind toxic metabolites and mitotoxines secreted by undesired microorganisms which, as a result, go through a digestive tract in the unchanged form and are egested with feces without any detrimental influence on the animal body -antioxidants, -other different food products (Matuszek 2012, Zawiślak et al., 2011Molognoni et al., 2017). The objective and scope of researchThe objective of the presented research is to improve physical properties of fodder additives with regard to the possibilities of a precise dosing to fodder mixtures and reduce their powder character. Methodology of researchTwo different aluminosilicates marked as follows were used in the tests: "Additive 1" and "Additive 2" as labels used in all stages of experiment. Aluminosilicates inclu...

show abstract

The role of measurement uncertainty in the conformity assessment of the chemical composition of feeds

Cited by 10 publications

References 29 publications

Cost-Effective and High-Reliability Analytical Approach for Multitoxin Screening in Bivalve Mollusks by Liquid Chromatography Coupled to Tandem Mass Spectrometry

Cost-Effective and High-Reliability Analytical Approach for Multitoxin Screening in Bivalve Mollusks by Liquid Chromatography Coupled to Tandem Mass Spectrometry

Current research, regulation, risk, analytical methods and monitoring results for nicarbazin in chicken meat: A perspective review

Evaluation of the Improvement Possibilities of Physical Properties of Mineral Fodder Additives

Contact Info

Product

Resources

About