The Role of Mean Platelet Volume as a Predictor of Mortality in Critically Ill Patients: A Systematic Review and Meta-Analysis

Tajarernmuang, Pattraporn; Phrommintikul, Arintaya; Limsukon, Atikun; Pothirat, Chaicharn; Chittawatanarat, Kaweesak

doi:10.1155/2016/4370834

Cited by 48 publications

(60 citation statements)

References 44 publications

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“…In adults, some studies showed that the initial MPV, as a predictor of mortality in critically ill patients, was not significantly associated with in-hospital mortality (19), although other studies showed that elevated MPV during hospitalization was a predictor of mortality in critically ill adults (9,20). High MPV was suggested to be associated with overall survival in various diseases such as cancer, cardiac disease, septic shock, kidney injury, and patients hospitalized in a respiratory intensive care unit (21)(22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Ohto

Nollet

et al. 2020

Front. Pediatr.

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Background: Platelets participate in many physiological and pathological functions and some platelet parameters predict adult diseases. However, few studies report whether platelet parameters may reflect neonatal disease and mortality in a large cohort.Objective: We aimed to investigate whether platelet parameters could predict bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), and NICU mortality. Study Design and Methods:This retrospective cohort study examined records from 2006 to 2017 at the neonatal intensive care unit (NICU) of Fukushima Medical University Hospital. We retrospectively investigated platelet count, plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW) on the first day of life in preterm newborns born <32 weeks' gestation admitted to our NICU from 2006 to 2017. Receiver operating characteristic (ROC) and multiple regression analyses, along with Cox proportional hazard modeling, identified independent predictors of morbidities and mortality in preterm newborns.Results: Of 1,501 neonates admitted to our NICU, a total of 305 preterm newborns were included in this study. Gestational age, birth weight, and Apgar score were significantly lower in non-survivors than in survivors. Platelet count, PCT, PDW and PMI did not differ significantly between the two groups, whereas mean MPV in non-survivors was significantly higher than in survivors (10.5 fl vs. 10.0 fl, p = 0.001). Multivariate Cox hazard modeling showed that shorter GA [HR: 0.628, 95% CI: 0.464-0.840, p = 0.003], male sex [HR: 0.269, 95% CI: 0.113-0.640, p = 0.001], and MPV [HR: 1.469, 95% CI: 1.046-2.063, p = 0.026] independently predicted overall survival. Per receiver operating curve, an MPV threshold of 10.2 fl. MPV predicts prognosis in neonates with a sensitivity of 72.4% and a specificity of 58.6% (AUC = 0.685, 95% CI: 0.600-0.789, p = 0.001). Furthermore, multivariate analysis revealed that platelet parameters were not associated Go et al. Platelet Parameters in Neonateswith BPD and NEC, whereas small for gestational age (SGA), Apgar score at 5 min, and low PCT were associated with intraventricular hemorrhage (IVH).Conclusion: This study demonstrates that low PCT predicts IVH, and MPV ≥ 10.2 fL correlates with mortality among infants born after <32 weeks' gestation.

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Section: Discussionmentioning

confidence: 99%

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Ohto

Nollet

et al. 2020

Front. Pediatr.

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“…This has been investigated in Cavalier King Charles Spaniels due to their hereditary macrothrombocytopenia, and in these dogs, a calculated plateletcrit could be superior to a platelet count for determining platelet mass . The mean platelet volume (MPV) can be a useful indication of the body's regenerative response to a reduced platelet mass; however, this has not become a routine measurement in veterinary hematologic analysis . The current study used only platelet count and review of a blood smear, so it could have benefitted from better assessment of platelet mass.…”

Section: Discussionmentioning

confidence: 99%

“…32 The mean platelet volume (MPV) can be a useful indication of the body's regenerative response to a reduced platelet mass; however, this has not become a routine measurement in veterinary hematologic analysis. 33,34 The current study used only platelet count and review of a blood smear, so it could have benefitted from better assessment of platelet mass.…”

Section: Discussionmentioning

confidence: 99%

Thrombocytosis in 715 Dogs (2011–2015)

Woolcock

Keenan

Cheung

et al. 2017

Veterinary Internal Medicne

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BackgroundThrombocytosis is a hematologic abnormality in dogs that has been associated with various neoplastic, metabolic, and inflammatory conditions.ObjectiveTo classify thrombocytosis in dogs based on severity and evaluate whether there are associations between severity and underlying disease processes.AnimalsSeven hundred and fifteen dogs with thrombocytosis and 1,430 dogs with normal numbers of platelets.MethodsRetrospective study. Medical records of dogs with increased (>500 × 103/μL; thrombocytosis group) and normal (300–500 × 103/μL; control group) platelet counts between 2011 and 2015 were reviewed. Dogs were characterized by severity of platelet increase and diagnosis. Diagnostic categories included neoplasia, endocrine disease, inflammatory disease, or miscellaneous.ResultsA total of 1,254 complete blood counts with thrombocytosis from 715 dogs were included in the study. Median platelet count in this population was 582 × 103/μL (500–1,810 × 103/μL). No correlation between severity of thrombocytosis and diagnosis was identified. Causes of secondary thrombocytosis included neoplasia (55.7%), endocrine disease (12.0%), and inflammatory disease (46.6%). Immune‐mediated disease was common (22.2%), associated with frequent glucocorticoid administration, and had a significantly higher median platelet count (636 × 103/μL [500–1,262 × 103/μL] versus 565 × 103/μL [500–1,810 × 103/μL]) when compared to the other inflammatory processes (P < 0.001). The diagnoses in the thrombocytosis dogs differed significantly from the control population (P < 0.001).Conclusions and Clinical ImportanceThrombocytosis is commonly associated with carcinoma and immune‐mediated disease in dogs.

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“…The MPV is calculated by automated blood analyzers, and is thought to be a marker of platelet activation in recent years [14-15]. Elevated MPV is also considered as a novel prognostic indicator in critically ill patients [16-19]. Moreover, some studies demonstrated an inverse relationship between MPV and platelet counts in critically ill patients.…”

Section: Introductionmentioning

confidence: 99%

Combination of Mean Platelet Volume/Platelet Count Ratio and the APACHE II Score Better Predicts the Short-Term Outcome in Patients with Acute Kidney Injury Receiving Continuous Renal Replacement Therapy

Sheng

et al. 2018

Kidney Blood Press Res

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Background/Aims: Both the Acute physiology and Chronic Health Evaluation (APACHE II) score and mean platelet volume/platelet count Ratio (MPR) can independently predict adverse outcomes in critically ill patients. This study was aimed to investigate whether the combination of them could have a better performance in predicting prognosis of patients with acute kidney injury (AKI) who received continuous renal replacement therapy (CRRT). Methods: Two hundred twenty-three patients with AKI who underwent CRRT between January 2009 and December 2014 in a Chinese university hospital were enrolled. They were divided into survivals group and non-survivals group based on the situation at discharge. Receiver Operating Characteristic (ROC) curve was used for MPR and APACHE II score, and to determine the optimal cut-off value of MPR for in-hospital mortality. Factors associated with mortality were identified by univariate and multivariate logistic regression analysis. Results: The mean age of the patients was 61.4 years, and the overall in-hospital mortality was 48.4%. Acute cardiorenal syndrome (ACRS) was the most common cause of AKI. The optimal cut-off value of MPR for mortality was 0.099 with an area under the ROC curve (AUC) of 0.636. The AUC increased to 0.851 with the addition of the APACHE II score. The mortality of patients with of MPR > 0.099 was 56.4%, which was significantly higher than that of the control group with of ≤ 0.099 (39.6%, P= 0.012). Logistic regression analysis showed that average number of organ failure (OR = 2.372), APACHE II score (OR = 1.187), age (OR = 1.028) and vasopressors administration (OR = 38.130) were significantly associated with poor prognosis. Conclusion: Severity of illness was significantly associated with prognosis of patients with AKI. The combination of MPR and APACHE II score may be helpful in predicting the short-term outcome of AKI.

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The Role of Mean Platelet Volume as a Predictor of Mortality in Critically Ill Patients: A Systematic Review and Meta-Analysis

Cited by 48 publications

References 44 publications

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Thrombocytosis in 715 Dogs (2011–2015)

Combination of Mean Platelet Volume/Platelet Count Ratio and the APACHE II Score Better Predicts the Short-Term Outcome in Patients with Acute Kidney Injury Receiving Continuous Renal Replacement Therapy

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