The role of maternal nutrition in the aetiology of gastroschisis: an incident case-control study

Paranjothy, Shantini; Broughton, Hannah K.; Evans, A. L.; Huddart, Simon; Drayton, Mark; Jefferson, Robert D; Rankin, Judith; Draper, Elizabeth S; Cameron, Alan; Palmer, S.R.

doi:10.1093/ije/dys092

Cited by 46 publications

(53 citation statements)

References 40 publications

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“…In our study, GS mothers were significantly younger than OC mothers ( P = 0.007) and CG mothers ( P < 0.001). Paranjothy et al described a relationship between low BMI and the incidence of GS . We found similar data.…”

Section: Discussionsupporting

confidence: 89%

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Risk factors for abdominal wall defects

Kapapa

Rieg

Henne‐Bruns

et al. 2019

Congenital Anomalies

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In the last decades, the prevalence of gastroschisis (GS) has increased worldwide. The purpose of this study was to identify maternal risk factors explaining the described gain and to identify differences between GS and omphalocele (OC). A case‐control design was used to compare GS (n = 36) and OC (n = 18) mothers to control group (CG; n = 30) matched for maternal age. Specialized questionnaires and mothers' prenatal records were used, and participants completed a structured interview. Focus was on medical history, changing nutrition, drug consumption, and external risk factors. The local ethics committee approved this study. GS mothers were significantly younger (mean 23.00; median 24; SD ±5) than OC (P = 0.007; mean 28.61; median 28, 19‐41; SD ±5.1) and CG (P = 0.001; mean 30.77; median 31, SD ±6.2). Mothers with abdominal wall defects (AWD) ingested antibiotics more often (P = 0.008) than CG. Socioeconomic characteristics, for example, level of profession, of GS mothers was significantly lower than OC (P = 0.039) and CG (P = 0.05) mothers, and their cohabitation time was shorter (P < 0.05; mean 35 month/median 24 month, SD ±35.8). Incidence of OC significantly increased after hormonal treatment (P = 0.022) and invasive prenatal diagnostics (P < 0.05) compared to GS. GS mothers took folic acid prophylaxis less often than OC (P = 0.02). Smoking, illicit drugs, and external risks like herbicides showed no influence, but GS mothers drink significantly more often alcohol (P = 0.05). We confirmed an increased risk for GS if several factors such as young maternal age, short cohabitation time, and usage of antibiotics coincide with alcohol consumption and associated immune diseases. OC increased after hormonal treatment and invasive prenatal diagnostics.

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Section: Discussionsupporting

confidence: 89%

“…Unfortunately, these costs are not covered by health insurance. Paranjothy et al showed that folic acid prophylaxis was protective for GS occurrence . In our study, 54% of OC mothers took folic acid prophylaxis, compared to 18% of GS ( P = 0.02) and 33% of CG mothers ( P = 0.129).…”

Section: Discussionmentioning

confidence: 40%

Risk factors for abdominal wall defects

Kapapa

Rieg

Henne‐Bruns

et al. 2019

Congenital Anomalies

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“…Feldkamp and colleagues reported that folic acid supplementation intake during early pregnancy was associated with reduced risk of gastroschisis (Feldkamp et al, 2011). Paranjothy et al reported that longer duration of taking folic acid supplementation significantly reduced the risk of fetal gastroschisis (Paranjothy et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…That is, we contribute new information on cleft lip with or without cleft palate as well as cleft palate alone, two phenotypes that have been previously suspected to be folate-related and whose prevalence has not been changing over time as dramatically as NTDs (Canfield et al, 2005;Yazdy et al, 2007;O'Neill, 2008;Golalipour et al, 2014). Furthermore, we examine gastroschisis, a birth defect that has been less studied for its potential folate relationship (Feldkamp et al, 2011;Paranjothy et al, 2012) and whose prevalence has been increasing dramatically over time in the United States and worldwide (Godwin et al, 2008;Vu et al, 2008;Srivastava et al, 2009;Benjamin et al, 2010;Kirby et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Folic acid fortification and prevalences of neural tube defects, orofacial clefts, and gastroschisis in California, 1989 to 2010

Yang

Carmichael

Shaw

2016

Birth Defects Research

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“…However, the mother did not receive periconceptional folic acid supplementation. Some authors consider this supplementation as having a protective effect [Paranjothy et al, 2012].…”

Section: Discussionmentioning

confidence: 99%