The role of maternal age on the risk of preterm birth among singletons and multiples: a retrospective cohort study in Lombardy, Northern Italy

Esposito, Giovanna; Mauri, Paola Agnese; Cipriani, Sonia; Franchi, Matteo; Corrao, Giovanni; Parazzini, Fabio

doi:10.1186/s12884-022-04552-y

Cited by 16 publications

(8 citation statements)

References 38 publications

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“…The relationship between residential area and preterm birth is assumed to be due to environmental factors, including socio-economic conditions and environmental conditions, such as pollution levels and water quality. Access to health services and the presence of health workers who can help mothers must also be considered [ 25 – 27 ]. A study conducted by Malwela et al [ 28 ], in rural areas in South Africa, shows that the cause of the increasing incidence of preterm births is the availability of equipment, which is less than 40%, making preterm births unpreventable.…”

Section: Discussionmentioning

confidence: 99%

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Differential DHA and EPA Levels in Women with Preterm and Term Births: A Tertiary Hospital Study in Indonesia

Aziz,

Hidayat,

Irwantoro

et al. 2024

Med Sci Monit

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Background Preterm birth is one of the main causes of neonatal death worldwide. One strategy focused on preventing preterm birth is the administration of long chain polyunsaturated fatty acids (LCPUFAs) during pregnancy. Omega-3 LCPUFAs, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are essential in metabolic and physiological processes during embryonic and fetal development. This study aimed to compare DHA and EPA levels in 44 women with preterm births and 44 women with term births at a tertiary hospital in West Java Province, Indonesia, between November 2022 and March 2023. Material/Methods A total of 88 patients in this study consisted of 44 patients with term births (≥37 gestational weeks) and 44 patients with preterm births (<37 gestational weeks) at a tertiary hospital in West Java Province, Indonesia. This observational, cross-sectional study was conducted from November 2022 to March 2023. Using the enzyme-linked immunosorbent assay test, maternal DHA and EPA levels were investigated. IBM SPSS 24.0 was used to statistically measure outcomes. Results Average maternal DHA and EPA levels in patients with preterm births were significantly lower than those in term births. Preterm labor risk was further increased by DHA levels of ≤5.70 μg/mL (OR=441.00, P =0.000) and EPA levels ≤3971.54 μg/mL (OR=441.00, P =0.000). Conclusions Since the average maternal DHA and EPA levels were significantly lower in patients with preterm births, adequate intake of omega-3 LCPUFA in early pregnancy and consistency with existing nutritional guidelines was associated with a lower risk of preterm delivery for pregnant women.

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Section: Discussionmentioning

confidence: 99%

“…The fetus’s only supply of this fatty acid comes from the mother’s body’s storage of EPA and DHA. The growing intrauterine fetus actively receives both EPA and DHA through the placenta [ 25 – 28 ]. Therefore, women with adequate omega-3 intake early in pregnancy should maintain such intake.…”

Section: Discussionmentioning

confidence: 99%

Differential DHA and EPA Levels in Women with Preterm and Term Births: A Tertiary Hospital Study in Indonesia

Aziz,

Hidayat,

Irwantoro

et al. 2024

Med Sci Monit

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“…Globally, in recent decades, with the increase in the PB rate, there is an increase in maternal age, but this relationship remains controversial. While some studies have found that maternal age is independently associated with PB [ 23 , 24 ], other studies have noted that both advanced maternal age and younger age have the same risk of PB [ 25 ]. The results of our study showed a mean age of 34.73 years (±5.32 years) in patients with PB, compared to 29.73 years (±8.48 years) in patients with TB, noting that there was a statistically significant difference between the two categories of TB/PB in terms of patient age.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the relationship between placental histopathological aspects of preterm and term birth

Camen

Istrate-Ofiţeru²,

Novac³

et al. 2022

Rom J Morphol Embryol

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Objectives: This study aims to establish a correlation between placental histopathological and immunohistochemical (IHC) changes and preterm birth with fetal growth restriction (FGR, formerly called intrauterine growth restriction -IUGR). Patients, Materials, and Methods: This prospective study was performed on a group of 30 parturients, with singleton gestation, of which 15 patients gave birth at term, and the other 15 patients gave birth prematurely. After the statistical correlation of the clinical and demographic data with premature birth (PB) and term birth (TB), we performed histological and IHC research on the respective placentae. To observe normal and pathological microscopic placental structures, we used the Hematoxylin-Eosin (HE) and Periodic Acid Schiff-Hematoxylin (PAS-H) classical stainings, but also special immunostaining with anti-cluster of differentiation 34 (CD34) and anti-vascular endothelial growth factor (VEGF) antibodies. Results: We found a statistically significant difference between the TB/PB categories and the age of the patients, their antepartum weight, the weight of the newborns, and the placenta according to the sex of the newborn. Histological analysis revealed in the case of TB, small areas of perivillous amyloid deposition, with the significant extension of these areas both intravillous and perivillous in the case of PB. Massive intravillous calcifications, syncytial knots, and intravillous vascular thrombosis were also frequently present in PB. With PAS-H staining were highlighted the intra/extravillous vascular basement membranes, but especially the massive fibrin deposits rich in glycosaminoglycans. By the IHC technique with the anti-CD34 antibody, we noticed the numerical vascular density, higher in the case of TB, but in the case of PB, there were large areas of placental infarction, with a lack of immunostaining in these areas. Through the anti-VEGF antibody, we observed the presence of signal proteins that determined and stimulated the formation of neoformation vessels in the areas affected by the lack of post-infarction placental vascularization. We observed a highly significant difference between placental vascular density between TB/PB and newborn weight, sex, or placental weight. Conclusions: Any direct proportional link between the clinical maternal-fetal and histological elements yet studied must be considered. Thus, establishing an antepartum risk group can prevent a poor pregnancy outcome.

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“…The main outcome of this study was the occurrence of preterm birth. Preterm birth was defined as <37 weeks gestation ( 1 ). IVF is considered an assisted reproductive technology (ART).…”

Section: Methodsmentioning

confidence: 99%

“…Preterm birth is defined as delivery at less than 37 completed weeks or 259 days of gestation; it has become one of the most important obstetric issues and is the main cause of perinatal morbidity and mortality ( 1 ). In addition, preterm birth is associated with increased health care costs ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Eclampsia, in vitro fertilization and the risk of preterm birth: a retrospective cohort study based on 2,880,759 samples

Wang¹,

Yin²,

Xue³

et al. 2023

Transl Pediatr

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Background Eclampsia and in vitro fertilization (IVF) are independent risk factors for preterm birth. Understanding the combined effects of multiple risk factors for preterm birth is critical to making accurate and personalized risk predictions. This study aimed to explore the interaction between eclampsia and IVF on the risk of preterm birth. Methods A total of 2,880,759 eligible participants from Birth Data Files in the National Vital Statistics System (NVSS) database 2019 were enrolled in this retrospective cohort study. Some characteristics were collected, such as maternal age, prepregnancy body mass index (BMI), history of preterm birth, paternal age, race, newborn sex. Preterm birth was defined as <37 weeks gestation. Univariate and multivariate logistic regression models were utilized to assess the associations between eclampsia, IVF and preterm birth. The odds ratio (OR) and 95% confidence interval (CI) were calculated in this study. Relative excess risk due to interaction (RERI), attributable proportion (AP) and synergy index (S) were adopted to evaluate the interaction between eclampsia and IVF on the risk of preterm birth. Results The age of mothers and fathers, the number of multiple births, the proportion of mothers with a history of preterm birth, pregnancy infections, eclampsia and IVF among the preterm birth group were all higher than those among the non-preterm birth group. The incidence of preterm birth in eclampsia and IVF population was approximately 37.31% and 22.96%, separately. After adjusting some covariates, subjects with both eclampsia and IVF had a higher risk of preterm birth (OR =9.197, 95% CI: 6.795–12.448, P<0.001). Furthermore, the results (RERI =3.426, 95% CI: 0.639–6.213, AP=0.374, 95% CI: 0.182–0.565, S =1.723, 95% CI: 1.222–2.428) suggested that the interaction between eclampsia and IVF on preterm birth was statistically significant, indicating a synergistic interaction. Conclusions Eclampsia and IVF might interact in a synergistic manner to increase the risk of preterm birth. Awareness of the risk profile associated with preterm birth is crucial for pregnant woman with IVF to implement dietary and lifestyle modifications.

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The role of maternal age on the risk of preterm birth among singletons and multiples: a retrospective cohort study in Lombardy, Northern Italy

Cited by 16 publications

References 38 publications

Differential DHA and EPA Levels in Women with Preterm and Term Births: A Tertiary Hospital Study in Indonesia

Differential DHA and EPA Levels in Women with Preterm and Term Births: A Tertiary Hospital Study in Indonesia

Analysis of the relationship between placental histopathological aspects of preterm and term birth

Eclampsia, in vitro fertilization and the risk of preterm birth: a retrospective cohort study based on 2,880,759 samples

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