The role of marrow accessory cell populations in the augmentation of human erythroid progenitor cell (BFU-E) proliferation by prostaglandin E

Nocka, Karl; Ottman, O.; Pelus, Louis M.

doi:10.1016/0145-2126(89)90119-7

Cited by 9 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These seemingly contradictory observations were elegantly explained by Gibson et al, who demonstrated that MSPCs initially enhance and then suppress erythroid colony formation [ 363 ]. This process was dependent on MSPC density and concentrations of MSPC-secreted PGE [ 363 , 364 ]. In vitro, PGE enhances erythropoiesis, and only seems to be produced by replicating MSPCs when present in low numbers, whereas static (i.e., non-replicating) or confluent (i.e., high cell numbers) MSPC layers produce no PGE and suppress blast forming unit-erythroid (BFU-E) formation [ 363 ].…”

Section: Mspcs and Their Progeny: Key Cellular Niche Componentsmentioning

confidence: 99%

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

Pleyer

Valent

Greil

2016

IJMS

View full text Add to dashboard Cite

Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders that have the capacity to progress to acute myeloid leukemia (AML). Accumulating evidence suggests that the altered bone marrow (BM) microenvironment in general, and in particular the components of the stem cell niche, including mesenchymal stem cells (MSCs) and their progeny, play a pivotal role in the evolution and propagation of MDS. We here present an overview of the role of MSCs in the pathogenesis of MDS, with emphasis on cellular interactions in the BM microenvironment and related stem cell niche concepts. MSCs have potent immunomodulatory capacities and communicate with diverse immune cells, but also interact with various other cellular components of the microenvironment as well as with normal and leukemic stem and progenitor cells. Moreover, compared to normal MSCs, MSCs in MDS and AML often exhibit altered gene expression profiles, an aberrant phenotype, and abnormal functional properties. These alterations supposedly contribute to the “reprogramming” of the stem cell niche into a disease-permissive microenvironment where an altered immune system, abnormal stem cell niche interactions, and an impaired growth control lead to disease progression. The current article also reviews molecular targets that play a role in such cellular interactions and possibilities to interfere with abnormal stem cell niche interactions by using specific targeted drugs.

show abstract

Section: Mspcs and Their Progeny: Key Cellular Niche Componentsmentioning

confidence: 99%

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

Pleyer

Valent

Greil

2016

IJMS

View full text Add to dashboard Cite

show abstract

“…The exact mechanism by which PGE2 exerts its effects on HSCs remains unknown. PGE2 has a regulatory role during myeloid differentiation, erythropoiesis and stromal cell homeostasis in murine BM (Fisher and Hagiwara, 1984; Nocka et al, 1989; Williams and Jackson, 1980). Additionally, hematopoietic lineage regeneration is impaired in cyclooxygenase (Cox) 2-deficient mice (Lorenz et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

Goessling

North

Loewer

et al. 2009

Cell

641

626

View full text Add to dashboard Cite

Summary Interactions between developmental signaling pathways govern the formation and function of stem cells. Prostaglandin (PG) E2 regulates vertebrate hematopoietic stem cells (HSC). Similarly, the Wnt signaling pathway controls HSC self-renewal and bone marrow repopulation. Here, we show that wnt reporter activity in zebrafish HSCs is responsive to PGE2 modulation, demonstrating a direct interaction in vivo. Inhibition of PGE2 synthesis blocked wnt-induced alterations in HSC formation. PGE2 modified the wnt signaling cascade at the level of β-catenin degradation through cAMP/PKA-mediated stabilizing phosphorylation events. The PGE2/Wnt interaction regulated murine stem and progenitor populations in vitro in hematopoietic ES cell assays and in vivo following transplantation. The relationship between PGE2 and Wnt was also conserved during regeneration of other organ systems. Our work provides the first in vivo evidence that Wnt activation in stem cells requires PGE2, and suggests the PGE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery.

show abstract

“…Similarly, we showed that PGE 2 enhances proliferation of multipotential progenitor cells that give rise to granulocytes, erythrocytes, monocytes and megakaryocytes (CFU-GEMM) [55,57]. In additional studies, we showed that PGE 2 increased BFU-E and CFU-GEMM, which could be direct [59] or mediated through factors released by T cells [56,57,59]. …”

Section: Pleiotropic Effects Of Prostaglandins On Hematopoiesismentioning

confidence: 98%

Pleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function

Pelus

Hoggatt

2011

Prostaglandins & Other Lipid Mediators

Self Cite

View full text Add to dashboard Cite

Eicosanoids have been implicated in the physiological regulation of hematopoiesis with pleiotropic effects on hematopoietic stem cells and various classes of lineage restricted progenitor cells. Herein we review the effects of eicosanoids on hematopoiesis, focusing on new findings implicating prostaglandin E2 in enhancing hematopoietic stem cell engraftment by enhancing stem cell homing, survival and self-renewal. We also describe a role for cannabinoids in hematopoiesis. Lastly, we discuss the yin and yang of various eicosanoids in modulating hematopoietic stem and progenitor cell functions and summarize potential strategies to take advantage of these effects for therapeutic benefit for hematopoietic stem cell transplantation.

show abstract

The role of marrow accessory cell populations in the augmentation of human erythroid progenitor cell (BFU-E) proliferation by prostaglandin E

Cited by 9 publications

References 23 publications

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

Pleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function

Contact Info

Product

Resources

About