The role of mannose binding lectin on fever episodes in pediatric oncology patients

Abstract

Despite significant changes in pediatric oncological therapy, mortality is still high, mainly due to infections. Complement system as an ancient immune defense against microorganisms plays a significant role in surmounting infections, therefore, deficiency of its components may have particular importance in malignancies. The present paper assesses the effect of promoter (X/Y) and exon 1 (A/0) polymorphisms of the MBL2 gene altering mannose binding lectin (MBL) serum level in pediatric oncological patients with febrile neutropenia. Furthermore, frequency distribution of MBL2 alleles in children with malignancies and age-matched controls was analysed. Fifty-four oncohematological patients and 53 children who had undergone pediatric surgery were enrolled into this retrospective study. No significant differences were found in the frequency of MBL2 alleles between the hemato-oncologic and control group. The average duration of fever episodes was significantly shorter (p = 0.035) in patients carrying genotypes (AY/AY and AY/AX) that encode normal MBL level, compared to individuals with genotypes associated with lower functional MBL level (AX/AX, AY/0, AX/0, or 0/0) (days, median (IQ range) 3.7(0-5.4) vs. 5.0(3.8-6.6), respectively). In conclusion, our data suggest that MBL2 genotypes may influence the course of febrile neutropenia in pediatric patients with malignancies, and may contribute to clarification of the importance of MBL in infections.

Genetic Sequence Variants in TLR4, MBL or IL-1 Receptor Antagonist is not Associated to Increased Risk for Febrile Neutropenia in Children with ALL

“…However, the definition of bacterial BSI and septic shock is not identical, hampering the comparisons of these two studies. Previous studies investigating MBL deficiency in children with cancer have reported contradictory results [8][9][10][11]14,15,39], whilst we could not show any association between MBL sequence variants and FN during the treatment for childhood ALL. Consequently, the present study strengthens the evidence that MBL does not play a role during episodes of FN and associated MDI.…”

“…Sequence variants in the TLR4 have been associated with an increased risk of sepsis, Gram-negative BSI, as well as the development of chemotherapy-induced neutropenia [11][12][13]. Data regarding sequence variants in the MBL and risk of FN in children during chemotherapy are inconclusive, with studies indicating an increased risk of bacterial infection, whilst some studies do not suggest any correlation to FN or any other MDI [9][10][11]14,15]. The IL1RN*2 allele has been associated with an increase in the susceptibility to sepsis and clinically severe sepsis in adults, but also to an increased risk of septic shock in children with ALL [7,16,17].…”

Two-Step Isolation, Purification, and Characterization of Lectin from Zihua Snap Bean (Phaseolus vulgaris) Seeds

“…Exploratory studies on their health benefits have been initiated, because lectins have important physiological roles, including insecticidal action [3,6], antibacterial activity [7], and antifungal effects [8], antihuman immunodeficiency virus [9], antitumor activity [10,11,12], and analgesic activity [13]. Plants are the main source of lectins that are found in different parts of plants such as seeds, leaves, bark, roots, tubers, and fruits [14].…”

The choice of enzyme preparation for mannose containing hydrolyzates with prebiotic activity obtaining

“…Манноза является неза-менимым углеводным компонентом имму-ноглобулинов и других биологически активных веществ, обладает пребиотическим действием [1]. Исследования показали, что этот углевод выполняет важную роль в живом организме [2,3], и может быть использован для профилактики и лечения урологических инфекций [4], диабета [5] и углевод-дефицитных гликопротеиновых синдромов I и II типов [6].…”