The Role of Manganese, Cadmium, Chromium and Selenium on Subjective Tinnitus

Atila, Nihal Efe; Atila, Alptuğ; Kaya, Zülküf; Bulut, Yunus; Öner, Fatih; Topal, Kübra; Bayraktutan, Zafer; Bakan, Ebubekîr

doi:10.1007/s12011-020-02420-4

Cited by 9 publications

(4 citation statements)

References 40 publications

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“…Selenium is associated with the activity of glutathione peroxidase, which is a cochlear anti-oxidant enzyme that deactivates ROS and RNS and specifically detoxifies H2O2 which induces ciliary dysfunction and apoptosis of hairy cells of the inner ear ( Atila et al, 2021 ). A deficiency of selenium reduces the effectiveness of glutathione peroxidase increasing H2O2 level and oxidative stress, and for this reason, it has been used in combination with B and E vitamin complexes in the treatment of idiopathic sudden hearing loss ( Kaya et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

The effect of MemoVigor 2 on recent-onset idiopathic tinnitus: a randomized double-blind placebo-controlled clinical trial

Balatsouras,

Papitsi,

Koukoutsis

et al. 2024

Front. Pharmacol.

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Background: Tinnitus is a common symptom associated with the conscious perception of sound in the absence of a corresponding external or internal sound source, which can severely impact quality of life. Because of the current limited understanding of the precise pathophysiological mechanism of idiopathic tinnitus, no curable treatment has been attained yet. A food supplement trading as MemoVigor 2, which contains a combination of therapeutic ingredients with mainly antioxidant activity, has been used in the treatment of tinnitus. The objective of our study was to evaluate the effectiveness of MemoVigor 2 in the treatment of recent-onset idiopathic tinnitus.Methods: In a prospective single-centre randomized, double-blind, placebo-controlled clinical trial we studied 204 patients with idiopathic tinnitus divided into two groups: 104 patients who received MemoVigor 2 and 100 patients treated with placebo. To evaluate changes in tinnitus we used (1) audiometry/tympanometry; (2) specific measures of tinnitus perception, including tinnitus pitch, loudness at tinnitus pitch, loudness at 1 kHz, minimum masking level, and residual inhibition; (3) questionnaires of tinnitus handicap inventory, mini tinnitus questionnaire and patients’ global impression of change. All patients underwent this test battery at the beginning of the study and in a repeat post-3-month session.Results: All tinnitus measures, including pitch, loudness, minimum masking level and residual inhibition improved significantly in the intervention group. Most of these measures improved in the placebo group too, but in a lesser degree. All questionnaire scores diminished significantly in both groups, but the degree of decrease was greater in the intervention group. The participants’ tinnitus outcome reported after treatment using the patients’ global impression of change score differed significantly between the two groups, with greater improvement observed in the intervention group.Conclusion: We found that the use of MemoVigor 2 improved recent-onset tinnitus, as proved by a set of tests performed for its evaluation, including audiometric measures, specific measures of tinnitus perception and tinnitus questionnaires. Tinnitus in the placebo group improved too, but to a lesser degree.Clinical Trial Registration: isrctn.com, Identifier ISRCTN16025480

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Section: Discussionmentioning

confidence: 99%

The effect of MemoVigor 2 on recent-onset idiopathic tinnitus: a randomized double-blind placebo-controlled clinical trial

Balatsouras,

Papitsi,

Koukoutsis

et al. 2024

Front. Pharmacol.

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“…Heavy metals inhaled with polluted air cause accumulation in the human body. Heavy metals trigger oxidative stress in the organism, increase reactive oxygen species, lipid peroxidation, and in ammatory cytokines, and exhibit harmful effects 4,26,27 . Oxidative stress plays a role in the etiopathogenesis of many diseases.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Levels of Heavy Metals in Nasal Concha Tissues in Rural and Urban Regions

Öner,

Kurt,

Üçüncü

2024

Preprint

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Background: Heavy metal exposure has recently become a problem due to the increasing environmental pollution as urbanization expands. Objective: This prospective case control study was conducted to compare levels of heavy metals in the nasal concha of the patients living in urban and rural who underwent partial inferior concha resection. Methods: Sixty-seven patients were divided into two groups: 38 rural patients and 29 urban patients. Lead (Pb), cadmium (Cd), mercury (Hg), copper (Cu), and manganese (Mn) levels were measured in inferior nasal concha by Inductively Coupled Plasma- Optical Emission Spectrometry. Results: Significance was considered at p < 0.05. The levels of Cu (0.24± 0.048 vs. 0.06± 0.019 µg/g) and Zn (3.29± 0.69 vs. 0.44± 0.14µg/g) of the rural patients were significantly higher compared to urban patients (p<0.001). There was no significant difference in the Cd level between groups. Pb (0.024± 0.009 vs. 0.008± 0.0002 µg/g) and Mn (0.273± 0.01 vs. 0.174± 0.05 µg/g) levels of urban patients were significantly higher than rural patients (p<0.001). Conclusions: Heavy metals accumulate in the nasal concha at different rates in rural and urban areas. Indicating the presence of heavy metals in turbinates and measuring their amount may be helpful for diagnostic purposes in diseases whose etiology is attributed to air pollution; however, the pathophysiology still needs to be clarified.

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“…Sodium and magnesium concentrations in leaf and stem of C.afer as reported in this research is in conformity with the data reported while phosphorus is low when compared to the result reported by Akpabio et al, (2011) [1] . Manganese is and important modulator of cell functions and play a vital role in the control of diabetes mellitus (Atila et al, 2021) [6] . Nickel serves as a co-factor of important antioxidant enzymes such as superoxide dismutase though it is in a small amount in both the leaf and stem as 0.26mg/kg and 0.24mg/kg respectively (Singh and kumar, 2021) [14] .…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of some selected minerals in <em>Costus afer </em>leaf and stem in Abakaliki, Nigeria

Ozioma¹,

Bando²,

David³

et al. 2022

Int. J. Adv. Biochem. Res.

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The study was carried out to evaluate the level of some mineral in Costus afer leaf and stem as it is been used in recently use in ethnomedicine for the treatment of diseases and also consume as vegetable by humans. The composition were evaluated using a standard method of AOAC, 2006. The result revealed a significant amount of heavy metals in the leaf in the order of calcium (74.52 ± 0.01 mg/g) > magnesium (31.71 ± 0.02 mg/g) >sodium (22.33 ± 0.02 mg/g) >manganese (7.31 ± 0.01 mg/g) >phosphorus (9.03 ± 0.02 mg/g) >potassium (6.91 ± 0.01 mg/g) >zinc (2.02 ± 0.01mg/g) >Nickel (0.26 ± 0.01 mg/g) >Iron (0.22 ± 0.01 mg/g) >lead (0.11 ± 0.02 mg/g) while the stem is in the order of calcium (70.23 ± 0.02 mg/g) >magnesium (37.64 ± 0.01) >potassium (16.45 ± 0.04 mg/g) >sodium (14.13 ± 0.02 mg/g) >phosphorus (10.42 ± 0.02 mg/g) > manganese (8.04 ± 0.04 mg/g) >zinc (2.23 ± 0.28 mg/g) >Iron (1.07 ± 0.01 mg/g) >lead (0.61 ± 0.01 mg/g) >nickel (0.24 ± 0.02 mg/g). Base on the result analyzed it is concluded that the plant can be used as an alternative and complimentary therapy for many oxidative stressed diseases and could be incorporated in nutraceutical, provided further scientific studies on the pharmacological and toxicological aspects are carried out.

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The Role of Manganese, Cadmium, Chromium and Selenium on Subjective Tinnitus

Cited by 9 publications

References 40 publications

The effect of MemoVigor 2 on recent-onset idiopathic tinnitus: a randomized double-blind placebo-controlled clinical trial

The effect of MemoVigor 2 on recent-onset idiopathic tinnitus: a randomized double-blind placebo-controlled clinical trial

Comparison of Levels of Heavy Metals in Nasal Concha Tissues in Rural and Urban Regions

Comparative analysis of some selected minerals in <em>Costus afer </em>leaf and stem in Abakaliki, Nigeria

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