The role of magnetic resonance imaging in Ménière disease: the current state of endolymphatic hydrops evaluation

Loureiro, Rafael Maffei; Sumi, Daniel Vaccaro; Lemos, Marcelo Delboni; Tames, Hugo Luis de Vasconcelos Chambi; Gomes, Regina Lúcia Elia; Daniel, Mauro Miguel; Soares, Carolina Ribeiro; Murakoshi, Rodrigo Watanabe; Funari, Marcelo Buarque de Gusmão

doi:10.31744/einstein_journal/2019md4743

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…Between 90 and 100% of MD patients reportedly exhibit prominent EH in the cochlea and/or vestibule according to MRI scans 24 , 27 , 28 . This frequency is similar to that associated with histopathological studies 29 . In the histopathology specimens used in the present study, the EH ratio of the affected side averaged 0.314 for the cochlea and 0.757 for the vestibule.…”

Section: Discussionsupporting

confidence: 89%

Validation of inner ear MRI in patients with Ménière’s disease by comparing endolymphatic hydrops from histopathologic specimens

Cho

Kim

et al. 2021

Sci Rep

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Intravenous gadolinium-enhanced inner-ear magnetic resonance imaging (IV-Gd inner-ear MRI) has been used to visualize endolymphatic hydrops (EH) in clinical diagnosis of Ménière’s disease (MD). However, lack of histological validation has led to several concerns regarding how best to interpret the resulting images. Here, we compared hydropic changes in temporal bone specimens with the results of IV-Gd inner-ear MRI in patients with MD. Histopathologic images of temporal bones from 37 patients with MD and 10 healthy controls were collected from the National Temporal Bone Bank of the Massachusetts Eye and Ear Infirmary in the United States. The EH ratios in the vestibule and cochlea were calculated from temporal bones using the methods used for IV-Gd inner-ear MRI, and the degree to which the saccular and utricular hydrops contributed to vestibular hydrops was measured. The presence of hydropic change in each semicircular canal was assessed using temporal bone images and compared with IV-Gd inner-ear MRI scans of 74 patients with MD. Based on human temporal bone imagery, the EH ratios in the cochlea and the vestibule on the affected side were 0.314 and 0.757, respectively. In the healthy control group, the ratio was 0.064 for the cochlea and 0.289 for the vestibule; these values were significantly different from those for the affected side of MD patients. The values for the affected ear were similar to the ratios from the IV-Gd inner-ear MRI scans in MD patients. In the vestibule, saccular hydrops were more common than utricular hydrops. The average EH ratios in the saccule and utricle were 0.513 and 0.242, respectively. No significant hydropic change from each of three semicircular canals was evident in temporal bone histopathology. However, herniation of otolithic organs (saccule or utricle) into the lateral semicircular canal was found in 44.4% of the patients, with saccular herniation (24.8%) more common than utricular herniation (16.7%). Although IV-Gd inner-ear MRI might not reflect fully the results of actual histopathology due to the limited resolution of MRI and image-processing techniques, the measured EH ratios from temporal bone specimens and IV-Gd inner-ear MRI scans were similar. Hydropic change in the three semicircular canals was not significant at either the ampullated or nonampullated end. Canal invasion of vestibular hydrops seen on MRI also appeared in temporal bone histopathology, and saccular invasion was dominant.

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Section: Discussionsupporting

confidence: 89%

Validation of inner ear MRI in patients with Ménière’s disease by comparing endolymphatic hydrops from histopathologic specimens

Cho

Kim

et al. 2021

Sci Rep

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“…[59] Many scholars have attempted to diagnose MD by visualizing the inner ear fluid compartments using gadolinium-enhanced MRI. [60] The currently used radiological hydrops grading systems include qualitative, semiquantitative, and volumetric scales. [61] Nakashima et al [62] performed a semiquantitative grading score based on a single-slice analysis within the cochlea, divided into no cochlear duct enlargement, moderate-grade, and significant-grade EH based on the extent of cochlear duct enlargement.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

A bibliometric and visualization study of Meniere’s disease: Current status and global hotspots and emerging trends

Wang

Zhang

et al. 2023

Medicine

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Background: Meniere's disease (MD) is a clinical condition characterized by endolymphatic hydrops. Persistent symptoms negatively affect patients mood, and the underlying etiology remains unclear. It is necessary to comprehensively understand the relevant publications, review the history and current status of research, and analyze hotspots and frontiers of research on MD.Methods: We retrieved literature on Meniere's disease from 2003 to 2022 from the Web of Science database and extracted the data. Data visualization and analysis was conducted using Cite Space, VOS viewer, an online web tool, and Microsoft Office Power Point 2019.Results: In total, 2847 publications were analyzed. The number of annual publications was relatively stable, with an accelerated upward trend over the past 5 years. The country with the most publications was USA (751, 26.38%), while the University of Munich contributed more publications than any other institution (117, 4.11%). The article titled "Diagnostic criteria for Meniere's disease" by Lopez-Escamez J et al in 2015 was the most cited and co-cited publication, and also had the top co-cited references with the strongest citation bursts. Naganawa S was the author with the most publications (85, 2.99%). The top 3 journals and co-cited journals were Otology Neurotology, Acta Oto Laryngologica, and Laryngoscope. Recently, the key theme words were "sensorineural hearing loss," "therapy," "intratympanic injection method," "vestibular-evoked myogenic potentials," "vestibular migraine," "magnetic resonance imaging," and "meniere's disease." Conclusions:The US has the largest number of publications and research institutions, many European countries have highquality journals, and Japan has the highest number of scholars. The international opinion on Meniere's disease is relatively uniform. The stepped-therapy for MD is scientific and clear. Intratympanic injection of steroids and intratympanic injection of gentamicin are commonly used, but steroids are considered safer. Saccular dysfunction may be more common in patients with MD than in those with utricular dysfunctions. It is worth paying attention to study the relationship between MD and vestibular migraine through headache. Progress in magnetic resonance imaging technology is still required for the imaging diagnosis of MD.

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“…Another recently developed MRI technique, currently used at only a few centers around the world ( 4 , 6 - 8 ) , has cast new light on the diagnosis of Ménière's disease (MD). It consists in performing MRI in a 3.0 T scanner 4 h after intravenous administration of paramagnetic contrast medium, employing a three-dimensional fluid-attenuated inversion recovery sequence for the diagnosis and grading of endolymphatic hydrops, which is present in up to 73% of patients with clinically possible MD, in 100% of those with clinically probable MD, and in 95% of those with clinically definite MD.…”

mentioning

confidence: 99%

“…It consists in performing MRI in a 3.0 T scanner 4 h after intravenous administration of paramagnetic contrast medium, employing a three-dimensional fluid-attenuated inversion recovery sequence for the diagnosis and grading of endolymphatic hydrops, which is present in up to 73% of patients with clinically possible MD, in 100% of those with clinically probable MD, and in 95% of those with clinically definite MD. Although not yet a diagnostic criterion, as a future perspective and with optimization of the technique, it could contribute to the diagnosis, influence therapeutic decision making, and play a role in follow-up evaluations ( 6 - 8 ) .…”

mentioning

confidence: 99%

Review and update of temporal bone imaging

Gomes

2019

Radiol Bras

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The role of magnetic resonance imaging in Ménière disease: the current state of endolymphatic hydrops evaluation

Cited by 8 publications

References 10 publications

Validation of inner ear MRI in patients with Ménière’s disease by comparing endolymphatic hydrops from histopathologic specimens

Validation of inner ear MRI in patients with Ménière’s disease by comparing endolymphatic hydrops from histopathologic specimens

A bibliometric and visualization study of Meniere’s disease: Current status and global hotspots and emerging trends

Review and update of temporal bone imaging

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