The Role of Macrophage-RNA in the Immune Response

Fishman, Marvin A.; Adler, Frank L.

doi:10.1101/sqb.1967.032.01.046

Cited by 77 publications

(24 citation statements)

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“…whether each of the two cells linked by the immunogenic molecule proceeds to produce antibody. A considerable body of evidence has accumulated for the cooperation of two different cell types in the immune stimulus (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37). 4 Some of this evidence suggests cooperation between a macrophage and a lymphocyte, whereas later evidence suggests cooperation between two different types of lymphocytes, both originating in the bone marrow, but one type modified by having undergone several cell divisions in the thymus ("thymus-derived cells"), and the other type not thus modified ("bone marrow-derived cells").…”

Section: Resultsmentioning

confidence: 99%

The Requirement of More Than One Antigenic Determinant for Immunogenicity

Rajewsky

Schirrmacher

Nase

et al. 1969

The Journal of Experimental Medicine

368

119

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Rabbits primarily stimulated with a BSA (bovine serum albumin)-sulfanilic acid complex will produce a good secondary response to the sulfanilic acid hapten if the carrier used in the secondary stimulus is again BSA, and not if the secondary carrier is HGG (human gamma globulin). In the latter situation, a good secondary response is obtained, however, if the rabbits are pretreated a few weeks earlier with free HGG. We conclude that the immune stimulus involves the recognition of carrier determinants unrelated to the hapten. As the receptors for recognition of unrelated determinants are probably situated on different cells, we suggest that the immune stimulus leading to antibody formation requires the interaction of two antigen-bridged cells.

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Section: Resultsmentioning

confidence: 99%

The Requirement of More Than One Antigenic Determinant for Immunogenicity

Rajewsky

Schirrmacher

Nase

et al. 1969

The Journal of Experimental Medicine

368

119

View full text Add to dashboard Cite

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“…An alternative explanation is that the immune deficiency is due to a block in the inductive or early proliferative phase of the immune response. This could be caused, for example, by a functional deficiency of the macrophage processing of SRBC antigen (25,26) or in the failure of the two or possibly three cell types involved in the immune response (27)(28)(29)(30)(31)(32) to interact properly. Studies are presently in progress to evaluate these possibilities.…”

Section: Discussionmentioning

confidence: 99%

Antibody and Immunoglobulin Production at the Cellular Level in Bursectomized-Irradiated Chickens

Alm

Peterson

1969

The Journal of Experimental Medicine

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The effect of bursectomy combined with sublethal X-irradiation in the newly hatched chicken on the immunoglobulin and antibody producing capacity in later life was investigated. The previous findings of a significant incidence of hypogammaglobulinemia in such animals were confirmed. Spleen cells from severely hypogammaglobulinemic animals synthesized and secreted little or no immunoglobulin. Such spleen lymphoid cells contained fewer immunoglobulin antigenic determinants than spleen cells from irradiated control animals as evidenced by their relative inability to respond by an increased DNA synthesis after in vitro culture with rabbit antiserum to chicken immunoglobulin. Therefore, the deficiency in the immunoglobulin synthesis extends not only to actively secreting cells such as plasma cells, but to the entire lymphoid cell population. As expected, most irradiated-bursectomized chickens, irrespective of plasma immunoglobulin levels failed to produce detectable amount of circulating antibodies to Brucella abortus antigen in the primary immune response. Severely hypogammaglobulinemic animals were completely unable to elaborate any plaque forming cells (PFC) in the primary response to sheep red blood cells (SRBC). The results of this investigation support the contention that in the severely hypogammaglobulinemic bursectomized-irradiated chicken the entire antibody producing and immunoglobulin producing cell line is absent. The possibility remains that precursor or stem cells are present but are not appropriately directed to antibody synthesis by other cell types.

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“…(a) They handle antigen and retain it in an immunogenic state (5,13,15,22); (b) they are efficient and fast transporters of antigen through the body (38,39); (c) they remove free antigen from the circulation (11,25). If the action of antigen is really a function of macrophage intervention, then the immunogenicity of an antigen is not only dependent on how much is stored or processed in an appropriate form and transported to antigen sensitive cells, but also on the amount and speed with which potentially tolerogenic material is degraded.…”

Section: Discussionmentioning

confidence: 99%