The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease

Schierwagen, Robert; Uschner, Frank Erhard; Ortiz, Cristina; Torres, Sandra; Brol, Maximilian Joseph; Tyc, Olaf; Gu, Wen; Zeuzem, Stefan; Plamper, Andreas; Pfeifer, Philipp; Zimmer, Sebastian; Welsch, Christoph; Schaefer, Liliana; Rheinwalt, Karl Peter; Clària, Joan; Arroyo, Vicente; Trebicka, Jonel; Klein, Sabine

doi:10.3389/fimmu.2020.01352

Cited by 17 publications

(22 citation statements)

References 47 publications

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“…The inhibitory activity against M. tuberculosis by lactobacilli is in agreement with a previous study (44). In an in vivo mouse model, Negi et al (45) found that a decrease in Bacteroidetes and Firmicutes, and an increase in Proteobacteria caused by antibiotics could result in the declined expression of macrophage-inducible Ca 2+ -dependent lectin receptor (mincle), which functions as a pattern recognition receptor recognizing and binding to the carbohydrate structure on pathogens including those on M. tuberculosis, and subsequently induce an innate immune response (46). In addition, gut microbiota alterations lead to increased burden of M. tuberculosis, a decreased effector and memory T cell population, and increased regulatory T cells in the lungs (45).…”

Section: Potential Role Of Probiotics and Postbioticssupporting

confidence: 90%

Microbiota and Tuberculosis: A Potential Role of Probiotics, and Postbiotics

Liu

Wang

2021

Front. Nutr.

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Tuberculosis (TB), caused by Mycobacterium tuberculosis attacking the lungs and other organs, is one of the most common infectious disease worldwide. According to the WHO's 2020 report, a quarter of the world's population were infected with M. tuberculosis, and ~1.4 million people died of TB. Therefore, TB is a significant public health concern, which requires cost-effective strategies for prevention and treatment. The microbiota has been considered as a “forgotten organ” and a complex dynamic ecosystem, which plays a significant role in many physiological processes, and its dysbiosis is closely associated with infectious disease. Recently, a few studies have indicated associations between TB and microbiota. This review summarizes studies concerning the alterations of the gut and respiratory microbiota in TB, and their relationship with host susceptibility to M. tuberculosis infection, indicating that microbiota signatures in different stages in TB progression could be considered as biomarkers for TB diagnosis and control. In addition, the potential role of probiotics and postbiotics in TB treatment was discussed.

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Section: Potential Role Of Probiotics and Postbioticssupporting

confidence: 90%

Microbiota and Tuberculosis: A Potential Role of Probiotics, and Postbiotics

Liu

Wang

2021

Front. Nutr.

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“…For example, non-alcoholic fatty liver disease is usually accompanied by changes in the intestinal microflora and bacterial overgrowth these are related to increased intestinal permeability and pathological bacterial translocation, in which macrophages may also be involved ( Bain and Mowat, 2014 ; Hundertmark et al, 2018 ). Macrophage inducible C-type lectin expressed on macrophages may contribute to the integrity of the intestinal barrier, but in the advanced stages of chronic liver disease, once the intestinal barrier leaks, it seems to cause inflammation and fibrosis ( Schierwagen et al, 2020 ). Receptor-interacting protein (RIP)-3, a member of the serine threonine kinase family, is the central mediator of necrosis and is associated with many human diseases ( Ramachandran et al, 2013 ; Roychowdhury et al, 2013 ; Linkermann and Green, 2014 ).…”

Section: Macrophages In the Intestinal Mucosa During Inflammationmentioning

confidence: 99%

Roles of Macrophages in the Development and Treatment of Gut Inflammation

Han

Ding

Jiang

et al. 2021

Front. Cell Dev. Biol.

108

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Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes according to their microenvironment. The large number of macrophages in the intestinal tract, play a significant role in maintaining the homeostasis of microorganisms on the surface of the intestinal mucosa and in the continuous renewal of intestinal epithelial cells. They are not only responsible for innate immunity, but also participate in the development of intestinal inflammation. A clear understanding of the function of macrophages, as well as their role in pathogens and inflammatory response, will delineate the next steps in the treatment of intestinal inflammatory diseases. In this review, we discuss the origin and development of macrophages and their role in the intestinal inflammatory response or infection. In addition, the effects of macrophages in the occurrence and development of inflammatory bowel disease (IBD), and their role in inducing fibrosis, activating T cells, reducing colitis, and treating intestinal inflammation were also reviewed in this paper.

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“…Few studies have investigated the association between lectin and liver disease. A recent study [ 50 ] shows that expression c type lectin plays an important role in different stages of chronic liver disease. It is possible that lectin is important for the immune response within tumour environment.…”

Section: Resultsmentioning

confidence: 99%

ORN: Inferring patient-specific dysregulation status of pathway modules in cancer with OR-gate Network

et al. 2021

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Pathway level understanding of cancer plays a key role in precision oncology. However, the current amount of high-throughput data cannot support the elucidation of full pathway topology. In this study, instead of directly learning the pathway network, we adapted the probabilistic OR gate to model the modular structure of pathways and regulon. The resulting model, OR-gate Network (ORN), can simultaneously infer pathway modules of somatic alterations, patient-specific pathway dysregulation status, and downstream regulon. In a trained ORN, the differentially expressed genes (DEGs) in each tumour can be explained by somatic mutations perturbing a pathway module. Furthermore, the ORN handles one of the most important properties of pathway perturbation in tumours, the mutual exclusivity. We have applied the ORN to lower-grade glioma (LGG) samples and liver hepatocellular carcinoma (LIHC) samples in TCGA and breast cancer samples from METABRIC. Both datasets have shown abnormal pathway activities related to immune response and cell cycles. In LGG samples, ORN identified pathway modules closely related to glioma development and revealed two pathways closely related to patient survival. We had similar results with LIHC samples. Additional results from the METABRIC datasets showed that ORN could characterize critical mechanisms of cancer and connect them to less studied somatic mutations (e.g., BAP1, MIR604, MICAL3, and telomere activities), which may generate novel hypothesis for targeted therapy.

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The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease

Cited by 17 publications

References 47 publications

Microbiota and Tuberculosis: A Potential Role of Probiotics, and Postbiotics

Microbiota and Tuberculosis: A Potential Role of Probiotics, and Postbiotics

Roles of Macrophages in the Development and Treatment of Gut Inflammation

ORN: Inferring patient-specific dysregulation status of pathway modules in cancer with OR-gate Network

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