The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy

Abstract

Asthma is a chronic respiratory disease frequently associated with airway inflammation and remodeling. The development of asthma involves various inflammatory phenotypes that impact therapeutic effects, and macrophages are master innate immune cells in the airway that exert diverse functions including phagocytosis, antigen presentation, and pathogen clearance, playing an important role in the pathogeneses of asthma. Recent studies have indicated that autophagy of macrophages affects polarization of phenotype and regulation of inflammation, which implies that regulating autophagy of macrophages may be a potential strategy for the treatment of asthma. Thus, this review summarizes the signaling pathways and effects of macrophage autophagy in asthma, which will provide a tactic for the development of novel targets for the treatment of this disease.

Role of autophagy and mitophagy of group 2 innate lymphoid cells in allergic and local allergic rhinitis

“…Furthermore, autophagy and mitophagy of nasal ILC2s were elevated in AR and LAR mice. Therapeutic targeting of autophagy has been applied in many fields, such as cancer, 53 asthma, 54 and neurodegenerative disorders. 55 Our findings suggest that autophagy and mitophagy have potential as therapeutic targets in AR and LAR.…”