The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases

Bergamini, Ettore; Cavallini, Gabriella; Donati, Alessio; Gori, Zina

doi:10.1016/j.biocel.2004.05.007

Cited by 137 publications

(94 citation statements)

References 99 publications

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“…60 Presumably, this can be ascribed to accelerated autophagy. 11,61 Calorie restriction also prolongs life and this, too, has been ascribed to increased autophagy. 11 For decades defective mitochondria and increased reactive oxygen species (ROS) formation have been implicated in the aging process.…”

Section: Defective Insulin Signaling Autophagy and Lifespanmentioning

confidence: 99%

“…11,61 Calorie restriction also prolongs life and this, too, has been ascribed to increased autophagy. 11 For decades defective mitochondria and increased reactive oxygen species (ROS) formation have been implicated in the aging process. 11 Clearly, autophagic removal of defective mitochondria is of crucial importance for cell survival.…”

Section: Defective Insulin Signaling Autophagy and Lifespanmentioning

confidence: 99%

“…11 For decades defective mitochondria and increased reactive oxygen species (ROS) formation have been implicated in the aging process. 11 Clearly, autophagic removal of defective mitochondria is of crucial importance for cell survival. Inhibition of autophagy by 3-MA in growth-arrested human fibroblasts, as a model of cell aging, results in the accumulation of lipofuscin-like material and of mitochondria, with a lowmembrane potential.…”

Section: Defective Insulin Signaling Autophagy and Lifespanmentioning

confidence: 99%

“…This activity is probably responsible for the antiaging role of autophagy. 9,11 However, autophagy can be stimulated by various stress situations, including nutrient depletion. During periods of nutrient shortage, autophagy provides the constituents required to maintain the metabolism essential for survival.…”

Section: Introductionmentioning

confidence: 99%

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Autophagy and signaling: their role in cell survival and cell death

2005

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Macroautophagy is a vacuolar, self-digesting mechanism responsible for the removal of long-lived proteins and damaged organelles by the lysosome. The discovery of the ATG genes has provided key information about the formation of the autophagosome, and about the role of macroautophagy in allowing cells to survive during nutrient depletion and/or in the absence of growth factors. Two connected signaling pathways encompassing class-I phosphatidylinositol 3-kinase and (mammalian) target of rapamycin play a central role in controlling macroautophagy in response to starvation. However, a considerable body of literature reports that macroautophagy is also a cell death mechanism that can occur either in the absence of detectable signs of apoptosis (via autophagic cell death) or concomitantly with apoptosis. Macroautophagy is activated by signaling pathways that also control apoptosis. The aim of this review is to discuss the signaling pathways that control macroautophagy during cell survival and cell death.

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Section: Defective Insulin Signaling Autophagy and Lifespanmentioning

confidence: 99%

Section: Defective Insulin Signaling Autophagy and Lifespanmentioning

confidence: 99%

Section: Defective Insulin Signaling Autophagy and Lifespanmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Autophagy and signaling: their role in cell survival and cell death

2005

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“…It has been suggested that autophagic activity might be downregulated with increased age. In addition, Bergamini et al 23 proposed that maintenance of autophagic activity could be at least partly responsible for the life-span extending property of caloric restriction in various species from yeast to mammals. Therefore, autophagic activity may be a critical determinant for lifespan.…”

Section: Intracellular Clearance By 'Baseline Autophagy': Antidegenermentioning

confidence: 99%

The pleiotropic role of autophagy: from protein metabolism to bactericide

2005

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Autophagy is in principle a nonselective, bulk degradation system within cells, with a contribution to intracellular protein degradation estimated to be as large as that of the ubiquitin--proteasome system. The primary roles of autophagy are baseline turnover of intracellular proteins and organelles, production of amino acids in nutrient emergency, and regression of retired tissues. These functions guarantee rejuvenation and adaptation to adverse conditions, and even underlie dynamic processes such as development/metamorphosis. In addition, several other roles for autophagy have recently been discovered, such as presentation of endogenous antigens and degradation of invasive bacteria. This review will discuss the biological significance of autophagy from yeast to higher eukaryotes.

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Cancer

Nicastro¹,

Milner²

2012

Present Knowledge in Nutrition

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The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases

Cited by 137 publications

References 99 publications

Autophagy and signaling: their role in cell survival and cell death

Autophagy and signaling: their role in cell survival and cell death

The pleiotropic role of autophagy: from protein metabolism to bactericide

Cancer

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