The Role of Lysyl Oxidase-like 2 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells

Kim, Joohyun; Lee, Eun-Hyang; Park, Hye-jeong; Park, Eui Kyun; Kwon, Tae-Geon; Shin, Hong‐In; Cho, Je‐Yoel

doi:10.1007/s10059-013-0080-3

Cited by 15 publications

(12 citation statements)

References 25 publications

(28 reference statements)

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“…In addition, while LOX, LOXL1, LOXL3, and LOXL4 levels are increased in adult human dental pulp stem cells (hDPSCs) that differentiate to odontoblast-like cells, LOXL2 is reduced at both mRNA and protein levels during the same process. Consistently, the inhibition of LOXL2 activity promotes hDPSC differentiation to odontoblasts [173]. In contrast, LOXL2 expression increases significantly during chondrocyte differentiation, and its depletion abolishes chondrocyte differentiation [174].…”

Section: Loxl2 and Cellular Differentiationmentioning

confidence: 74%

Lysine-Specific Histone Demethylases Contribute to Cellular Differentiation and Carcinogenesis

Verde

Querol-Paños²,

Cebrià-Costa³

et al. 2017

Epigenomes

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Histone modifications regulate chromatin structure, gene transcription, and other nuclear processes. Among the histone modifications, methylation has been considered to be a stable, irreversible process due to the slow turnover of methyl groups in chromatin. However, the discovery of three different classes of lysine-specific demethylases-KDM1, Jumonji domain-containing demethylases, and lysyl oxidase-like 2 protein-has drastically changed this view, suggesting a role for dynamic histone methylation in different biological process. In this review, we describe the different mechanisms that these enzymes use to remove lysine histone methylation and discuss their role during physiological (cell differentiation) and pathological (carcinogenesis) processes.

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Section: Loxl2 and Cellular Differentiationmentioning

confidence: 74%

Lysine-Specific Histone Demethylases Contribute to Cellular Differentiation and Carcinogenesis

Verde

Querol-Paños²,

Cebrià-Costa³

et al. 2017

Epigenomes

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“…Kim et al[ 39 ] demonstrated that lysyl oxidase-like 2 (LOXL2) expression is decreased during odontogenic differentiation of DPSCs. Exogenous application of human recombinant LOXL2 protein resulted in a decrease in odontogenic differentiation.…”

Section: Discussionmentioning

confidence: 99%

Proteomic profiling of various human dental stem cells - a systematic review

Hosmani

Assiri

Almubarak

et al. 2020

WJSC

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BACKGROUND The proteomic signature or profile best describes the functional component of a cell during its routine metabolic and survival activities. Additional complexity in differentiation and maturation is observed in stem/progenitor cells. The role of functional proteins at the cellular level has long been attributed to anatomical niches, and stem cells do not deflect from this attribution. Human dental stem cells (hDSCs), on the whole, are a combination of mesenchymal and epithelial coordinates observed throughout craniofacial bones to pulp. AIM To specify the proteomic profile and compare each type of hDSC with other mesenchymal stem cells (MSCs) of various niches. Furthermore, we analyzed the characteristics of the microenvironment and preconditioning changes associated with the proteomic profile of hDSCs and their influence on committed lineage differentiation. METHODS Literature searches were performed in PubMed, EMBASE, Scopus, and Web of Science databases, from January 1990 to December 2018. An extra inquiry of the grey literature was completed on Google Scholar, ProQuest, and OpenGrey. Relevant MeSH terms (PubMed) and keywords related to dental stem cells were used independently and in combination. RESULTS The initial search resulted in 134 articles. Of the 134 full-texts assessed, 96 articles were excluded and 38 articles that met the eligibility criteria were reviewed. The overall assessment of hDSCs and other MSCs suggests that differences in the proteomic profile can be due to stem cellular complexity acquired from varied tissue sources during embryonic development. However, our comparison of the proteomic profile suffered inconsistencies due to the heterogeneity of various hDSCs. We believe that the existence of a heterogeneous population of stem cells at a given niche determines the modalities of regeneration or tissue repair. Added prominences to the differences present between various hDSCs have been reasoned out. CONCLUSION Systematic review on proteomic studies of various hDSCs are promising as an eye-opener for revisiting the proteomic profile and in-depth analysis to elucidate more refined mechanisms of hDSC functionalities.

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“…Collagen density was abnormally low in both the palate and vertebral primordia in knockout embryos. Both cleft palate and ocular abnormalities occur in a human family which has missense mutation in the Loxl3 gene, but the ocular phenotype was not observed in mice 151, 152 . Two splice variants of LOXL3 have been identified 153, 154 .…”

Section: Bodymentioning

confidence: 96%

Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and Cancer

Trackman

2016

Expert Opinion on Therapeutic Targets

101

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Introduction The lysyl oxidase family of enzymes is classically known as being required for connective tissue maturation by oxidizing lysine residues in elastin and lysine and hydroxylysine residues in collagen precursors. The resulting aldehydes then participate in cross-link formation, which is required for normal connective tissue integrity. These enzymes have biological functions that extend beyond this fundamental biosynthetic role, with contributions to angiogenesis, cell proliferation, and cell differentiation. Dysregulation of lysyl oxidases occurs in multiple pathologies including fibrosis, primary and metastatic cancers, and complications of diabetes in a variety of tissues. Areas covered This review summarizes the major findings of novel roles for lysyl oxidases in pathologies, and highlights some of the potential therapeutic approaches that are in development and which stem from these new findings. Expert opinion Fundamental questions remain regarding the mechanisms of novel biological functions of this family of proteins, and regarding functions that are independent of their catalytic enzyme activity. However, progress is underway in the development of isoform-specific pharmacologic inhibitors, potential therapeutic antibodies and gaining an increased understanding of both tumor suppressor and metastasis promotion activities. Ultimately, this is likely to lead to novel therapeutic agents.

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The Role of Lysyl Oxidase-like 2 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells

Cited by 15 publications

References 25 publications

Lysine-Specific Histone Demethylases Contribute to Cellular Differentiation and Carcinogenesis

Lysine-Specific Histone Demethylases Contribute to Cellular Differentiation and Carcinogenesis

Proteomic profiling of various human dental stem cells - a systematic review

Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and Cancer

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