The role of lysosomes in the phenomenon of concentration of aluminum and indium in the female reproductive system. An ultrastructural study

Mhamdi, Marwa; Florea, Adrian; Badri, Nedra; Maghraoui, Samira; Matei, Horea; Walid-Habib, Tekaia; Baati, R.; Tekaya, Leila

doi:10.1016/j.jtemb.2017.05.009

Cited by 10 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reduced ingestion rate in Daphnia after cadmium exposure was suggested to be a key mechanism impairing energy uptake and thus reproduction and growth . Despite potentially reduced ingestion rate, the highest concentrations of Al and In were detected in the midgut, which is in line with other studies on metal uptake in D. magna . Al crossing cell membranes by endocytosis are found accumulated in lysosomes. , The lysosome cellular component (Table S3) was enriched in all the treatment groups and endocytosis in the mixture, suggesting their involvement in Al and In accumulation and effects.…”

Section: Discussionsupporting

confidence: 85%

See 1 more Smart Citation

Mixtures of Aluminum and Indium Induce More than Additive Phenotypic and Toxicogenomic Responses in Daphnia magna

Brun

Fields

Horsfield

et al. 2019

Environ. Sci. Technol.

View full text Add to dashboard Cite

Aquatic systems are contaminated by many metals but their effects as mixtures on organisms are not well understood. Here, we assessed effects of aluminum with fairly well-known modes of actions and indium, an understudied emerging contaminant from electronics, followed by studying equi-effective mixtures thereof. We report acute and adverse phenotypic effects in Daphnia magna adults and global transcriptomic effects employing RNA sequencing in neonates. The mixture induced more than additive activity in mortality, and in physiological effects, including growth and reproduction. Similarly, transcriptomic effects were more than additive, as indicated by a markedly higher number of 463 differentially expressed transcripts in the mixture and by distinct classes of genes assigned to several biological functions, including metabolic processes, suggesting depleted energy reserves, which may be responsible for the observed impaired reproduction and growth. A gene set enrichment analysis (GSEA) of a priori known response pathways for aluminum confirmed activation of distinct molecular pathways by indium. Our study is highlighting more than additive effects at the transcriptional and physiological level and is providing a state-of-the art approach to mixture analysis, which is important for risk assessment of these metals and metal mixtures.

show abstract

Section: Discussionsupporting

confidence: 85%

“…52 Al crossing cell membranes by endocytosis are found accumulated in lysosomes. 52,53 The lysosome cellular component (Table S3, SI) was enriched in all the treatment groups and endocytosis in the mixture, suggesting their involvement 21…”

mentioning

confidence: 99%

Mixtures of Aluminum and Indium Induce More than Additive Phenotypic and Toxicogenomic Responses in Daphnia magna

Brun

Fields

Horsfield

et al. 2019

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Our ultrastructural results reminder many previous studies describing that cerium, a mineral element which belonging to the same group of lanthanum, was found within the lysosomes of intestinal mucosa, liver, kidney, suprarenal, and testicular glands cells [14] as well as endometrium and myometrium cells, granulosa and internal theca cells of the ovary [15]. In addition, our observed deposits were similar to those founded with gadolinium in alveolar macrophages [17,10], liver cells, spleen, bone marrow, proximal renal cells [20], endometrium, myometrium, granulosa and internal theca cells [13]. Indeed, the same processes of precipitation within the lysosomes were highlighted with heavy metals.…”

Section: Discussionsupporting

confidence: 73%

“…For example, the III A group of the Mendeleev chart, such as gallium, which deposits were identified in the lysosomes of tumoral cells [6], and aluminum selectively concentrated in the lysosomes of bone marrow, liver, and mammary gland cells [7][8][9]. As for rare earths, gadolinium was found in several kinds of cells such as alveolar macrophages, liver cells [10][11][12], endometrium, myometrium, granulosa and internal theca cells [13]. An intralysosomal detection of cerium was mentionnated in the intestinal mucosa, liver, kidney, suprarenal, and testicular glands [14].…”

Section: Discussionmentioning

confidence: 99%

Transplacental Passage and Subcellular Accumulation of Lanthanum within Maternal and Fetus side of Placenta: A Transmission Electron Microscopy Study

Badri¹,

Maroua²,

Florea³

et al. 2018

Biol syst Open Access

Self Cite

View full text Add to dashboard Cite

Placenta is a privileged organ which has a storage function during pregnancy. Thus, it establishes an interface between maternal circulation and fetus. Therefore, any deviation from normal placental development may constitute a potential threat to fetus growth. In this work, we try to study the subcellular behavior as well as the effects of lanthanum (La), on placenta of gestating rats after its intraperitoneal injection under soluble solution. Using TEM, the ultrastructural observations of placenta tissues from lanthanum-treated rats showed many electron-dense surcharges in the lysosomes of maternal connective tissues from maternal part of placenta as well as syncytiotrophoblast and cytotrophoblast from fetus side of placenta respectively. At a concentration of 48 mg/kg, lanthanum was found to cause change in nucleus contouring, vacuolations, expansion of the rough endoplasmic reticulum, mitochondrial sufferance and cytoplasmic rarefication. These modifications covered both side of placenta. The ultrastructural study of control rats showed a normal aspect of the ultrastructure of the two parts of placenta. Finally, our data strongly suggests the transplacental passage of lanthanum and its accumulation within the lysosomes of both side of placenta which may constitute a potential threat to fetus growth and development. We try through this work to study the cellular distribution of lanthanum after its intraperitoneal administration as a soluble solution to attempt to characterize its eventual transfer across the placenta from mother to the fetus.

show abstract

“…A study published in the J Trace Elem Med Bio highlighted fine ultrastructural details of cellular components from myometrial and endometrium cells, and in the cells of the ovary (internal theca and granulosa cells). Lysosomes were extracted, and the analysis compared with other tissues shows crystallized fragments inside the lysosomes as part of their cellular role by phagocytosing aluminum ready for disposal [ 238 ]. Here a suggestion was made to assess endocrine function and female fertility with aluminum exposure.…”

Section: Trace Elements and Female Reproductive Organsmentioning

confidence: 99%

Essentiality of Trace Elements in Pregnancy, Fertility, and Gynecologic Cancers—A State-of-the-Art Review

et al. 2021

View full text Add to dashboard Cite

Gynecological neoplasms pose a serious threat to women’s health. It is estimated that in 2020, there were nearly 1.3 million new cases worldwide, from which almost 50% ended in death. The most commonly diagnosed are cervical and endometrial cancers; when it comes to infertility, it affects ~48.5 million couples worldwide and the number is continually rising. Ageing of the population, environmental factors such as dietary habits, environmental pollutants and increasing prevalence of risk factors may affect the reproductive potential in women. Therefore, in order to identify potential risk factors for these issues, attention has been drawn to trace elements. Trace mineral imbalances can be caused by a variety of causes, starting with hereditary diseases, finishing with an incorrect diet or exposure to polluted air or water. In this review, we aimed to summarize the current knowledge regarding trace elements imbalances in the case of gynecologic cancers as well as female fertility and during pregnancy.

show abstract

The role of lysosomes in the phenomenon of concentration of aluminum and indium in the female reproductive system. An ultrastructural study

Cited by 10 publications

References 17 publications

Mixtures of Aluminum and Indium Induce More than Additive Phenotypic and Toxicogenomic Responses in Daphnia magna

Mixtures of Aluminum and Indium Induce More than Additive Phenotypic and Toxicogenomic Responses in Daphnia magna

Transplacental Passage and Subcellular Accumulation of Lanthanum within Maternal and Fetus side of Placenta: A Transmission Electron Microscopy Study

Essentiality of Trace Elements in Pregnancy, Fertility, and Gynecologic Cancers—A State-of-the-Art Review

Contact Info

Product

Resources

About