2008
DOI: 10.1002/jso.21209
|View full text |Cite
|
Sign up to set email alerts
|

The role of lymphadenectomy in esophageal cancer

Abstract: Lymph node metastases are common in esophageal cancer and are associated with a poor prognosis. Resection and examination of 15-18 lymph nodes is required for adequate staging of esophageal cancer. Improved survival is associated with involvement of five or fewer nodes or lymph node ratio (LNR) of < 0.10-0.20. More extensive lymph node dissection during esophagectomy offers improved staging but may also provide therapeutic benefit in terms of control of locoregional disease and possibly improved overall surviv… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
30
0

Year Published

2011
2011
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 43 publications
(31 citation statements)
references
References 29 publications
1
30
0
Order By: Relevance
“…However these differences were not large enough to show significance, presumably because of the relatively small number of patients recruited. Furthermore, as several studies have reported correlations between dissected lymph node numbers and long-term survival (21,22), we recommend that a larger scale comparative study should be conducted on RE and TE.…”
Section: Figurementioning
confidence: 99%
“…However these differences were not large enough to show significance, presumably because of the relatively small number of patients recruited. Furthermore, as several studies have reported correlations between dissected lymph node numbers and long-term survival (21,22), we recommend that a larger scale comparative study should be conducted on RE and TE.…”
Section: Figurementioning
confidence: 99%
“…These micrometastatic deposits can be detected with immunohistochemical analysis using monoclonal antibodies to stain tumour-specific antigens or using Polymerase Chain reaction (PCR) at the molecular level [37][38][39][40][41][42][43][44]. It is unclear whether these nodal micrometastases represent tumour cells with metastatic potential or just shredded cells, which will be cleared by the immune system or remain dormant in a non-proliferating phase [39,45].…”
Section: Micrometastases In Lymph Nodesmentioning
confidence: 99%
“…Studies have demonstrated that distant lymph node metastases occur in up to 40% of patients, with T2 and T3 tumours having a prevalence of 31% and 40% positive distant lymph nodes, respectively [11,42,59]. Distant lymph node metastases to upper mediastinum lymph nodes occur almost exclusively in patients with extensive regional lymph node involvement [96,100].…”
Section: A C C E P T E D Accepted Manuscriptmentioning
confidence: 99%
“…Epidemiological studies indicate that ESCC is the fifth most common cause of cancer-related mortality in men (1). Despite significant improvements in diagnosis and treatment including surgery, chemotherapy and radiotherapy, patient prognosis remains poor, with a 5-year survival rate of 15-34% (2)(3)(4). Systemic chemotherapy with cisplatin and 5-fluorouracil (5-FU) is the most commonly used treatment regimen for advanced ESCC.…”
Section: Introductionmentioning
confidence: 99%