The role of lncRNAs and exosomal lncRNAs in cancer metastasis

Zhang, Yutong; Zhao, Lijuan; Bi, Yaping; Jin-yuan, Zhao; Gao, Chao; Si, Xiaoyan; Dai, Hongyue; Asmamaw, Moges Dessale; Zhang, Qiurong; Chen, Wenchao; Liu, Hong‐Min

doi:10.1016/j.biopha.2023.115207

Cited by 3 publications

(3 citation statements)

References 164 publications

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“…43 Tumor-derived exosomes can carry a large number of substances, including proteins, nucleic acids, and lipids, among them, exosome lncRNAs not only play a role in ccRCC diagnosis and prognosis, but also can be used as therapeutic targets, playing a crucial role in ccRCC progression and the spread of drug resistance. 44 Therefore, through various mechanical learning methods, we screened out four key exosome-related lncRNAs (EMX2OS, AC026401.3, AC018690.1, and AL161935.1) and constructed the four exosome-related lncRNAs (4-ERLR)-based score for ccRCC. Among these four ln-cRNAs, EMX2OS and AC026401.3 have been closely correlated with ccRCC progression in previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, due to their high mobility and lipid bilayer structure, they can easily passthrough biological membranes and protect rich bioactive substances present inside the membranes from degradation 43 . Tumor‐derived exosomes can carry a large number of substances, including proteins, nucleic acids, and lipids, among them, exosome lncRNAs not only play a role in ccRCC diagnosis and prognosis, but also can be used as therapeutic targets, playing a crucial role in ccRCC progression and the spread of drug resistance 44 …”

Section: Discussionmentioning

confidence: 99%

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Exosome‐related lncRNA score: A value‐based individual treatment strategy for predicting the response to immunotherapy in clear cell renal cell carcinoma

Yang,

Zhang,

Zhan

et al. 2024

Cancer Medicine

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BackgroundExosomes play a crucial role in intercellular communication in clear cell renal cell carcinoma (ccRCC), while the long non‐coding RNAs (lncRNAs) are implicated in tumorigenesis and progression.AimsThe purpose of this study is to construction a exosomes‐related lncRNA score and a ceRNA network to predict the response to immunotherapy and potential targeted drug in ccRCC.MethodsData of ccRCC patients were obtained from the TCGA database. Pearson correlation analysis was used to identify eExosomes‐related lncRNAs (ERLRs) from Top10 exosomes‐related genes that have been screened. The entire cohort was randomly divided into a training cohort and a validation cohort in equal scale. LASSO regression and multivariate cox regression was used to construct the ERLRs‐based score. Differences in clinicopathological characteristics, immune microenvironment, immune checkpoints, and drug susceptibility between the high‐ and low‐risk groups were also investigated. Finally, the relevant ceRNA network was constructed by machine learning to analyze their potential targets in immunotherapy and drug use of ccRCC patients.ResultsA score consisting of 4ERLRs was identified, and patients with higher ERLRs‐based score tended to have a worse prognosis than those with lower ERLRs‐based score. ROC curves and multivariate Cox regression analysis demonstrated that the score could be considered as a risk factor for prognosis in both training and validation cohorts. Moreover, patients with high scores are predisposed to experience poor overall survival, a larger prevalence of advanced stage (III‐IV), a greater tumor mutational burden, a higher infiltration of immunosuppressive cells, and a greater likelihood of responding favorably to immunotherapy. The importance of EMX2OS was determined by mechanical learning, and the ceRNA network was constructed, and EMX2OS may be a potential therapeutic target, possibly exerting its function through the EMX2OS/hsa‐miR‐31‐5p/TLN2 axis.ConclusionsBased on machine learning, a novel ERLRs‐based score was constructed for predicting the survival of ccRCC patients. The ERLRs‐based score is a promising potential independent prognostic factor that is closely correlated with the immune microenvironment and clinicopathological characteristics. Meanwhile, we screened out key lncRNAEMX2OS and identified the EMX2OS/hsa‐miR‐31‐5p/TLN2 axis, which may provide new clues for the targeted therapy of ccRCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exosome‐related lncRNA score: A value‐based individual treatment strategy for predicting the response to immunotherapy in clear cell renal cell carcinoma

Yang,

Zhang,

Zhan

et al. 2024

Cancer Medicine

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“…Accumulating evidence has highlighted the connection between the dysregulation of lncRNAs and the initiation and progression of diverse disorders, such as cardiovascular disease 7 - 9 , cholestatic liver disease 10 - 12 , and particularly malignancy 13 - 16 . Furthermore, in-depth investigations have illuminated the pivotal role that lncRNAs play in the development of various diseases, exerting influence over processes such as lipid metabolism 17 , 18 , cellular aging 19 - 22 , and an array of biological behaviors associated with tumors 23 - 28 , including cell migration, invasion, and metastasis. This paradigm extends further as lncRNAs have risen as promising candidates for clinical applications, owing to the deepening exploration of the molecular mechanisms that govern the multifaceted functionalities of numerous lncRNAs.…”

Section: Introductionmentioning

confidence: 99%

LINC00839 in Human Disorders: Insights into its Regulatory Roles and Clinical Impact, with a Special Focus on Cancer

Hu,

et al. 2024

J. Cancer

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LINC00839 has captured significant attention within a spectrum of human disorders, including acute lung injury, osteoarthritis, and childhood obesity. Notably, aberrant expression patterns of LINC00839 have been observed across diverse cancer tissues and cell lines. LINC00839 emerges as an oncogenic factor in tumorigenesis and exerts a positive influence on tumor-associated behaviors. Its therapeutic potential for various cancers is underscored by its modulatory impact on pivotal signaling pathways, such as PI3K/AKT, OXPHOS, and Wnt/β-catenin. Additionally, LINC00839's role in reducing sensitivity to drug and radiotherapy interventions presents opportunities for targeted intervention. Furthermore, elevated LINC00839 expression indicates advanced clinicopathological features and foretells unfavorable prognoses, as validated by publications and comprehensive analyses of tumor types using TCGA datasets. This review elucidates the multiple regulatory mechanisms and functional implications of LINC00839 in various diseases, especially malignancies, emphasizing its potential as a predictive biomarker and therapeutic target across multiple disease domains in humans.

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Metastasis suppressor genes in clinical practice: are they druggable?

Gelman

2023

Cancer Metastasis Rev

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The role of lncRNAs and exosomal lncRNAs in cancer metastasis

Cited by 3 publications

References 164 publications

Exosome‐related lncRNA score: A value‐based individual treatment strategy for predicting the response to immunotherapy in clear cell renal cell carcinoma

Exosome‐related lncRNA score: A value‐based individual treatment strategy for predicting the response to immunotherapy in clear cell renal cell carcinoma

LINC00839 in Human Disorders: Insights into its Regulatory Roles and Clinical Impact, with a Special Focus on Cancer

Metastasis suppressor genes in clinical practice: are they druggable?

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