The role of liver-directed surgery in patients with hepatic metastasis from primary breast cancer: a multi-institutional analysis

Margonis, Georgios Antonios; Buettner, Stefan; Sasaki, Kazunari; Kim, Yuhree; Ratti, Francesca; Russolillo, Nadia; Ferrero, Alessandro; Berger, Nicholas G.; Gamblin, T. Clark; Poultsides, George A.; Tran, Thuy B.; Postlewait, Lauren M.; Maithel, Shishir K.; Michaels, Alex D.; Bauer, Todd W.; Marques, Hugo P.; Barroso, Eduardo; Aldrighetti, Luca; Pawlik, Timothy M.

doi:10.1016/j.hpb.2016.05.014

Cited by 49 publications

(47 citation statements)

References 20 publications

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“…Recent studies have observed between 36 and 58% of 5-year survival rates. [1][2][3][4] Theseresults seem similar the most recent series published by our team for the surgical treatment of LMCRC. 12 Since for LMBC that were treated by means HR, long term survival or even cure can be attained.…”

Section: Discussionsupporting

confidence: 79%

“…This strategy has been designated as "adjuvant surgical debulking" when LMBC are resected by means hepatectomy after systemic therapy. [1][2][3][4][5][6] Nowadaysthis approach has been widespread in oncological scenario around the world. However, many questions still need to be answered, for example: How should we choose or even select the patients whocan present a true benefit with an aggressive surgical treatment of LMBC?…”

Section: Discussionmentioning

confidence: 99%

“…The more important PG for LMBC that have been described in the literature are: both number and diameter of lesions, extra-hepatic disease, disease-free survival time between primary lesion treatment and development of liver metastasis, preoperative chemotherapy, response to chemotherapy, microscopic margins,microscopic vascular or lymphatic invasion, hormone receptors (ER and PgR) andmore recently receptor of HER2. [1][2][3][4][5][6][7][8] These PG have been shown as significant to attain a longterm survival. [1][2][3][4][5][6][7][8] Currently, new biological prognostic factors have been largely studied in relation to BC, especially those designated as biomarkers.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, HR for LMBC has been considered anapproach reasonable for very selected situations. [1][2][3][4][5][6][7][8] Recently, "first-liver approach" or reverse surgery has been extensively studied for treatment of synchronous liver metastasis of colorectal cancer (LMCRC). Long-term results may be similar to those observed when is performed the classical approach.…”

Section: Introductionmentioning

confidence: 99%

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Reverse surgery (“first-liver approach”) for hepatic metastases from breast cancer

Costa¹,

Botan²,

Araujo³

et al. 2018

GHOA

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Background: Hepatic resection for liver metastasis from breast cancer (LMBC) canattain long-term survival. Since BC has been a very sensitive neoplasm to chemotherapy, surgical resection of residual LMBC has presented an important role associated withsystemic therapy. Reverse approach ("first liver approach") has been performed for liver metastasis from colorectal cancer (LMCRC), mainly for multiple synchronic metastases that have presented partial response. Case report: We report a case of LMBC in young female who has undergone successful"first liver approach" after partial response tosystemic therapy. At first, it was performed open right hepatectomy with caudate lobectomy and atypical resection of three small lesions in left lobe. After two postoperative cycles of chemotherapy associated a target therapy, she has finally submitted a radical mastectomy and selective axillary lymphadenectomy. To date, thirty months after hepatic resection, she is alive without any recurrence.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Reverse surgery (“first-liver approach”) for hepatic metastases from breast cancer

Costa¹,

Botan²,

Araujo³

et al. 2018

GHOA

View full text Add to dashboard Cite

show abstract

“…The R1 resection indicates "macroscopically clean" preparation of margins, yet, the histopathological analysis indicates the presence of tumor on preparation margins. The R2 resection indicates that preparation margins are neither macroscopically nor microscopically "clean" 16,[28][29][30][31] . Our assumption is that pathohistological analysis of tumor and peritumoral tissue is insufficient and an examination on the molecular level is required for better prediction of tumor progression.…”

Section: Discussionmentioning

confidence: 99%

The concentration of matrix metalloproteinase 9 in the tumor and peritumoral tissue as prognostic marker in breast cancer patients

et al. 2019

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Background/Aim. Breast cancer is one of the most common malignancies among women all over the world. Tumor microenvironment represents one of the main regulators of tumorigenesis. We investigated the role of matrix metalloproteinases 9 (MMP-9) concentration in peritumoral tissue as a prognostic marker in the breast cancer patients. Methods. The ELISA test was used to determine a total MMP-9 concentration in carcinoma and peritumoral tissue sample in the patients with breast cancer. Comparison of MMP-9 protein expression with the clinicopathological parameters was evaluated. Results. Peritumoral tissue at 3 cm distance from the tumor produces more MMP-9 than the tumor itself. The ratio of concentrations of MMP-9 in the tumor and peritumoral tissue considerably changes in favor of peritumoral tissue with the increase of tumor size and the involvement of axillary lymph nodes. In N0 stage, the concentration ratio of MMP-9 in the tumor and peritumoral tissues was 1 : 1.44, but in the N2 stage, the ratio was 1 : 26.5. Conclusion. In patients with breast cancer even in an early stadium there is a change in MMP-9 concentration in peritumoral tissue. We can extract the group of patients at increased risk for the development of lymph node metastasis. A statistically significant difference between the concentrations of MMP-9 in the peritumoral tissue and cancer tissue exists only in case of metastatic disease not in MO stadium implying need for early detection of still unknown metastases in such patients.

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Worth it or not? Primary tumor resection for stage IV pancreatic cancer patients: A SEER‐based analysis of 15,836 cases

Weng

et al. 2021

Cancer Medicine

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The role of liver-directed surgery in patients with hepatic metastasis from primary breast cancer: a multi-institutional analysis

Abstract: In selected patients, resection of breast cancer liver metastases can be done safely and a subset of patients may derive a relatively long survival, especially from a margin negative resection.

Cited by 49 publications

References 20 publications

Reverse surgery (“first-liver approach”) for hepatic metastases from breast cancer

Reverse surgery (“first-liver approach”) for hepatic metastases from breast cancer

The concentration of matrix metalloproteinase 9 in the tumor and peritumoral tissue as prognostic marker in breast cancer patients

Worth it or not? Primary tumor resection for stage IV pancreatic cancer patients: A SEER‐based analysis of 15,836 cases

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