The Role of Lipid Intrinsic Curvature in the Droplet Interface Bilayer
Jamie Gudyka,
Jasmin Ceja-Vega,
Michael Krmic
et al.
Abstract:Model bilayers are constructed from lipids having different intrinsic curvatures using the droplet interface bilayer (DIB) method, and their static physicochemical properties are determined. Geometrical and tensiometric measurements are used to derive the free energy of formation (ΔF) of a two-droplet DIB relative to a pair of isolated aqueous droplets, each decorated with a phospholipid monolayer. The lipid molecules employed have different headgroup sizes but identical hydrophobic tail structure, and each is… Show more
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