Abstract:The antimicrobial peptide double cooperative effect, where the mixture of two major antimicrobial peptides LL-37 and HNP1 kills bacteria more efficiently while minimizing the host damage by suppressing mammalian cell membrane lysis, has garnered attentions due to its potential applications towards efficient and safe antibiotics. However, its mechanism is completely unknown. In this work, we report that the double cooperative effect can be partially recapitulated in synthetic lipid systems just by varying the l… Show more
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