The role of limbic system structures in the regulation of ACTH secretion

Adrenocortical Responses following Limbic Stimulation in Rats with Hypothalamic Deafferentations

“…Thus, in the rat [2], the rabbit [ 13], the cat [3,36] and the monkey [21], an initial rise, of varying degree, in adrenocortical secretion was observed in association with hippocampal stimulation; this rise was generally followed by inhibitory effects. In the cat, septal stimulation generally depressed adrenocortical secretion, although an occasional increase has also been observed [3,36].…”

Schizophrenia—a parameters’ game?

“…Vulnerability to schizophrenia has been correlated to volume reductions in several brain areas: amygdala, hippocampus and prefrontal cortex (PFC) (Yuii et al, 2007). This is not surprising, since the limbic system is primarily associated with the regulation of emotion and arousal, and is also responsible for integrating the internal and external environments via its wide connections with the neocortex (Anand, 2005), as well as with the autonomic (Amann and Constantinescu, 1990), and endocrine (Mason et al, 1961) systems. Recent studies (Medoff et al, 2001;Preston, 2005;Tamminga, 2006) support the theory that the vulnerability to stress in schizophrenia is based on a pre-existing hippocampal/prefrontal deficit.…”

Feedback Effects of Dexamethasone on Adrenocortical Responses in Rats with Fornix Section

“…In such preparations, dexamethasone had a significantly smaller inhibitory effect on the adrenocortical discharge following ether stress, when compared with intact rats (6). With the purpose to identify other neural structures which participate in this mechanism and in view of the role played by the hippocampus ' in modifying the neuroendocrine regulation of adrenocortical activity (4,(10)(11)(12)15), the feedback effect of dexamethasone on the adrenocortical re sponse was studied in rats with bilateral fornix section.…”