The role of lifetime stressors in adult fibromyalgia: a response to Joan S. Crawford's letter to the editor

Kaleycheva, Nia; Cullen, Alexis E.; Evans, Robyn; Harris, Tirril; Nicholson, Timothy R; Chalder, Trudie

doi:10.1017/s0033291721002828

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The only clear difference was in the rate of prior (lifetime) psychiatric disorders which was greater in the functional somatic syndromes. The possible reasons for this lies outside the range of variables included in this study; genetic factors and childhood abuse might be two possible candidates [ 11 , 73 – 76 ].…”

Section: Conclusion and Recommendationsmentioning

confidence: 99%

Psychiatric disorders comorbid with general medical illnesses and functional somatic disorders: The Lifelines cohort study

Creed

2023

PLoS ONE

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Objective It is not clear why psychiatric disorders are more prevalent in the functional somatic syndromes than other general medical illnesses. This study assessed the correlates of psychiatric disorders in 3 functional syndromes and 3 general medical illnesses in a population-based sample. Methods The Lifelines cohort study included 122,366 adults with relevant data for 6 self-reported conditions: irritable bowel syndrome (IBS), fibromyalgia, chronic fatigue syndrome (CFS), inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and diabetes. For each condition the proportion with a DSM-IV psychiatric disorder was assessed. In a cross-sectional design, logistic regression identified at baseline the variables most closely associated with current psychiatric disorder in participants with a pre-existing medical or functional condition. In a separate analysis the prevalence of psychiatric disorder prior to onset of these conditions was assessed. This was a longitudinal study with psychiatric disorder assessed at baseline in participants who subsequently developed a general medical or functional condition between baseline and follow-up. Results The prevalence of psychiatric disorder was higher (17–27%) in the functional somatic syndromes than the general medical illnesses (10.4–11.7%). The variables closely associated with psychiatric disorder were similar in the functional syndromes and general medical illnesses: stressful life events, chronic personal health difficulties, neuroticism, poor perception of general health, impairment of function due to physical illness and reported previous (lifetime) psychiatric disorder. The prevalence of psychiatric disorder prior to development of these disorder was similar to that of established disorders. Conclusion Despite the difference in prevalence, the correlates of psychiatric disorders were similar in functional and general medical disorders and included predisposing and environmental factors. The increased rate of psychiatric disorder in functional somatic syndromes appears to be evident before onset of the syndrome.

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Section: Conclusion and Recommendationsmentioning

confidence: 99%