The role of leukotriene inhibition using a 5‐lipoxygenase (5‐LO) inhibitor in a joint contracture model
Alexander D. Jeffs,
Michael Boyd,
Landon Larabee
et al.
Abstract:Purpose
Arthrofibrosis is a common inflammatory complication of joint trauma and surgery. 5lipoxygenase (5-LO) is a key enzyme involved in inflammation. Inhibition of 5-LO has been shown to reduce inflammation in heart and lung models but has not been examined in a joint contracture model.
Methods
Twenty-six rats underwent joint contracture. Six rats served as non-surgical controls. A 5-LO inhibitor, caffeic acid (CA), suspended in 10% ethanol was … Show more
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