The Role of Length of Nerve Exposed to Local Anesthetics in Impulse Blocking Action

Raymond, Scott B.; Steffensen, Scott C.; Gugino, Laverne D.; Strichartz, Gary R.

doi:10.1213/00000539-198905000-00004

Cited by 170 publications

(118 citation statements)

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“…In addition, the quantitative relationship between the concentration of local anesthetic, the length of nerve exposed, and degree of conduction blockade was studied by others authors 13 . In summary, the study indicated that recordings of the compound action potential and of single axons established that small variations in the length of nerve exposed to local anesthetic strongly modulate conduction block even at exposure lengths in excess of 2 centimeters.…”

Section: Discussionmentioning

confidence: 99%

A cadaveric study to determine the minimum volume of methylene blue to completely color the nerves of brachial plexus in cats. An update in forelimb and shoulder surgeries

Mencalha¹,

Fernandes²,

Sousa

et al. 2014

Acta Cir. Bras.

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PURPOSE:To determine the minimum volume of methylene blue (MB) to completely color the brachial plexus (BP) nerves, simulating an effective anesthetic block in cats. METHODS:Fifteen adult male cat cadavers were injected through subscapular approach with volumes of 2, 3, 4, 5 and 6 ml in both forelimbs, for a total of 30 brachial plexus blocks (BPB). After infusions, the specimens were carefully dissected preserving each nervous branch. The measurement of the effective area was indicated by the impregnation of MB. Nerves were divided into four segments from the origin at the spinal level until the insertion into the thoracic limb muscles. The blocks were considered effective only when all the nerves were strongly or totally colored. RESULTS:Volumes of 2, 3 and 4 ml were considered insufficient suggesting a failed block, however, volumes of 5 and 6 ml were associated with a successful block. CONCLUSIONS:The injection of methylene blue, in a volume of 6 ml, completely colored the brachial plexus. At volumes of 5 and 6 ml the brachial plexus blocks were considered a successful regional block, however, volumes of 2, 3 and 4 ml were considered a failed regional block.

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Section: Discussionmentioning

confidence: 99%

A cadaveric study to determine the minimum volume of methylene blue to completely color the nerves of brachial plexus in cats. An update in forelimb and shoulder surgeries

Mencalha¹,

Fernandes²,

Sousa

et al. 2014

Acta Cir. Bras.

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show abstract

“…Neural blockade occurs when 3 consecutive nodes are blocked. 28 In this situation, the cylinder height would be 0.6 to 6 mm. The volume needed could now be as low as 1.8 μ L.…”

Section: No Physiological Selectivitymentioning

confidence: 99%

The Problem With Diagnostic Selective Nerve Root Blocks

Shah¹

2012

Spine

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“…The reason why tumescent local anesthesia can provide longer duration of analgesia is explained not only by the slow absorption of lidocaine but also by the duration and length of the nerve segment exposed to lidocaine [8,9]. Postoperative analgesia of 18 h has been reported by Klein [6] and up to 24 h by Bussolin et al [10] in pediatric patients.…”

Section: Discussionmentioning

confidence: 99%

Severe post-burn neck contracture release and skin graft harvest using tumescent local anaesthesia as the sole anesthetic technique

et al. 2011

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Severe post-burn contractures in the neck often cause anatomical distortion and restriction of neck movements, resulting in varying degrees of difficulty in airway management. Any mode of anesthesia that may obviate the need for imperative airway control may be desirable in such situations in which a difficult airway may be anticipated. Here we present one such situation where tumescent local anesthesia was employed to manage a case of severe post-burn neck contractures posted for contracture release and split-skin grafting. The other benefits of this method were minimal blood loss and excellent postoperative analgesia. In conclusion, it can be emphasized that the application of tumescent anesthesia is an important anesthetic tool in patients with predicted difficult airway management.

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The Role of Length of Nerve Exposed to Local Anesthetics in Impulse Blocking Action

Cited by 170 publications

References 0 publications

A cadaveric study to determine the minimum volume of methylene blue to completely color the nerves of brachial plexus in cats. An update in forelimb and shoulder surgeries

A cadaveric study to determine the minimum volume of methylene blue to completely color the nerves of brachial plexus in cats. An update in forelimb and shoulder surgeries

The Problem With Diagnostic Selective Nerve Root Blocks

Severe post-burn neck contracture release and skin graft harvest using tumescent local anaesthesia as the sole anesthetic technique

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