The role of lactate in intermolecular regulation of protein structures interaction

Gilmiyarova, F. N.; Kolotieva, N.A.; Potekhina, V.I.; Baisheva, G.M.; Ryskina, E.A.

doi:10.21145/2499-9954-2017-2-99-101

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2019

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“…The series of experiments clearly showed biodiversity in metabolic state of different ABO groups which allow us to create metabolic passport for each blood group summarizing the key data [19].…”

Section: Discussionmentioning

confidence: 99%

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ABO Blood Group Antigens as a Model of Studying Protein-Protein Interactions

Gylmiyarova¹,

Ryskina²,

Kolotyeva³

et al. 2019

Blood Groups

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This work presents a research of intermolecular interactions on the example of the antigen antibody interactions of the ABO system. This model could be successfully used in the future due to the lack of knowledge in the area of the ABO antigen's behavior as a biomolecule and the integration of these structures into chain of metabolic processes in a human being. Using computer PASS system ("in silico" research), we describe the possible biological effects of pyruvate, lactate, and antigen determinants A and B. Glycoproteins A and B are very perspective to study as biological active connectors due to the wide range of their biological effects. The obtained knowledge proves that ABO antigen, as well as other glycoprotein conjugates, could play an important role in intercellular adhesion and signal transmission, which could be used in perspective in personalized medicine, target therapy, and evaluation of lab results in clinical practice.

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Section: Discussionmentioning

confidence: 99%

“…Owners of the third blood group are characterized by sufficient good health. They have the highest level of albumin, cholesterol [19].…”

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confidence: 99%