The Role of Labile Iron on Brain Proteostasis; Could it be an Early Event of Neurodegenerative Disease?
Aiyarin Kittilukkana,
Jannarong Intakhat,
Chalermchai Pilapong
Abstract:Iron deposits in the brain are a natural consequence of aging. Iron accumulation, especially in the form of labile iron, can trigger a cascade of adverse effects, eventually leading to neurodegeneration and cognitive decline. Aging also increases the dysfunction of cellular proteostasis. The question of whether iron alters proteostasis is now being pondered. Herein, we investigated the effect of ferric citrate, considered as labile iron, on various aspects of proteostasis of neuronal cell lines, and also estab… Show more
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