The role of L-DOPA in plants

Soares, Anderson Ricardo; Marchiosi, Rogério; Siqueira-Soares, Rita de Cássia; Lima, Rogério Barbosa de; Santos, Wanderley Dantas dos; Ferrarese-Filho, Osvaldo

doi:10.4161/psb.28275

Cited by 141 publications

(100 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The concept of tyrosine‐rich metabolism is compelling but incomplete, as numerous diverse lineages of angiosperms exhibit the metabolic signature of tyrosine‐rich metabolism (e.g. the presence of high concentrations of l ‐DOPA in species within Fabaceae) (Soares et al ., ). The example of hyperaccumulated l ‐DOPA from Fabaceae is particularly instructive, as l ‐DOPA is the key precursor to betalamic acid, yet to our knowledge betalains are not reported in Fabaceae.…”

Section: The Origin Of Betalain Pigmentation In Caryophyllalesmentioning

confidence: 99%

The evolution of betalain biosynthesis in Caryophyllales

et al. 2019

View full text Add to dashboard Cite

Summary Within the angiosperm order Caryophyllales, an unusual class of pigments known as betalains can replace the otherwise ubiquitous anthocyanins. In contrast to the phenylalanine‐derived anthocyanins, betalains are tyrosine‐derived pigments which contain the chromophore betalamic acid. The origin of betalain pigments within Caryophyllales and their mutual exclusion with anthocyanin pigments have been the subject of considerable research. In recent years, numerous discoveries, accelerated by ‐omic scale data, phylogenetics and synthetic biology, have shed light on the evolution of the betalain biosynthetic pathway in Caryophyllales. These advances include the elucidation of the biosynthetic steps in the betalain pathway, identification of transcriptional regulators of betalain synthesis, resolution of the phylogenetic history of key genes, and insight into a role for modulation of primary metabolism in betalain synthesis. Here we review how molecular genetics have advanced our understanding of the betalain biosynthetic pathway, and discuss the impact of phylogenetics in revealing its evolutionary history. In light of these insights, we explore our new understanding of the origin of betalains, the mutual exclusion of betalains and anthocyanins, and the homoplastic distribution of betalain pigmentation within Caryophyllales. We conclude with a speculative conceptual model for the stepwise emergence of betalain pigmentation.

show abstract

Section: The Origin Of Betalain Pigmentation In Caryophyllalesmentioning

confidence: 99%

The evolution of betalain biosynthesis in Caryophyllales

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In fact, many plant species are sensitive to L-DOPA, including weeds and crops (Hachinohe et al 2004;Nishihara et al 2004;Topal and Kocaçaliskan 2006). In general, L-DOPA reduces seed germination and suppresses root growth (Fujii 1999;Nakajima et al 1999;Hachinohe et al 2004;Nishihara et al 2004;Nishihara et al 2005), but Leguminosae and Gramineae species are less affected than species of Brassicaceae, Cucurbitaceae, Compositae, and Hydrophyllaceae (Soares et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Photosynthetic response of soybean to L-DOPA and aqueous extracts of velvet bean

et al. 2016

Self Cite

View full text Add to dashboard Cite

L-3,4-Dihydroxyphenylalanine (L-DOPA) is an allelochemical released by roots of velvet bean (Mucuna pruriens) that affects the growth of several plant species. However, its mechanism of action is inconclusive. In this work, we compared the effects of L-DOPA (0.01-1.0 mmol L -1 ) and of aqueous extracts (300, 1200, and 3000 mg L -1 ) of velvet bean on growth and photosynthesis (gas exchange and chlorophyll a fluorescence) of soybean (Glycine max). Overall, the results showed that both L-DOPA and aqueous extracts of velvet bean reduced the growth, leaf area, photosynthetic rate (A), stomatal conductance (g s ), transpiration (E), and quantum yield of electron flow through photosystem II (PSII) in vivo (U F ). In addition, L-DOPA and aqueous extracts increased the internal CO 2 concentration (Ci) and the leaf wax and trichome density on the leaf surface, while the maximum quantum yield of PSII (F v /F m ) was not changed. These results suggest that the reduction of A should not be related exclusively to the stomatal closure, but also to limitations of the carbon metabolism, as indicated by the increase of Ci and decrease of U F . Briefly, we concluded that soybean growth inhibition by L-DOPA and aqueous extracts of velvet bean is due to the combination of damage in the root meristem and reduction in A.

show abstract

“…D-dopachrome is an artificial substrate of mammalian MIF and other MDLs and is a cyclization product of D-3,4-dihydroxyphenylalanine (also known as D-DOPA), suggesting a role in the biosynthesis of melanin-type pigments. While plants lack conventional melanin, they synthesize catechol melanin, which is chemically related to L-DOPA and might serve a role as precursor of different secondary plant metabolites (melanin) (Solano, 2014; Soares et al, 2014). …”

Section: Non-mammalian Mif Homologues Identified Throughout the Eumentioning

confidence: 99%

The non-mammalian MIF superfamily

et al. 2017

View full text Add to dashboard Cite

Macrophage migration inhibitory factor (MIF) was first described as a cytokine 50 years ago, and emerged in mammals as a pleiotropic protein with pro-inflammatory, chemotactic, and growth-promoting activities. In addition, MIF has gained substantial attention as a pivotal upstream mediator of innate and adaptive immune responses and with pathologic roles in several diseases. Of less importance in mammals is an intrinsic but non-physiologic enzymatic activity that points to MIF's evolution from an ancient defense molecule. Therefore, it is not surprising that mif-like genes also have been found across a range of different organisms including bacteria, plants, protozoa, helminths, molluscs, arthropods, fish, amphibians and birds. While Genebank analysis identifying mif-like genes across species is extensive, contained herein is an overview of the non-mammalian MIF-like proteins that have been most well studied experimentally. For many of these organisms, MIF contributes to an innate defense system or plays a role in development. For parasitic organisms however, MIF appears to function as a virulence factor aiding in the establishment or persistence of infection by modulating the host immune response. Consequently, a combined targeting of both parasitic and host MIF could lead to more effective treatment strategies for parasitic diseases of socioeconomic importance.

show abstract

The role of L-DOPA in plants

Cited by 141 publications

References 56 publications

The evolution of betalain biosynthesis in Caryophyllales

The evolution of betalain biosynthesis in Caryophyllales

Photosynthetic response of soybean to L-DOPA and aqueous extracts of velvet bean

The non-mammalian MIF superfamily

Contact Info

Product

Resources

About