The role of L-arginine and aerobic exercise in experimental renal ischemia reperfusion injury in male and female rats

Vafamand, Effatsadat; Bolboli, Lotfali; Talebi, Ardeshir; Nematbakhsh, Mehdi

doi:10.18869/acadpub.hmj.21.1.20

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…The results of this study showed that administration of L-arg and exercise training ameliorated renal dysfunction and kidney damage induced by renal I/R in male gender, although Cr values were not changed by L-arg. In agreement with these results, it is demonstrated that kidney function was improved by L-arg or exercise in renal I/R in normal diet fed male rats (29).…”

Section: The Effect Of L-arg or Exercise Concomitant Hfd On I/rsupporting

confidence: 84%

“…Exercise training and L-arg administration improved renal function and histopathology in males but not in females. In inconsistent with these observations, it was reported that both exercise and L-arg recovered renal failure induced by kidney I/R in both male and female genders fed by normal diet (29). It seems that the main reason of this contrast is different diets in two studies.…”

Section: The Effect Of L-arg or Exercise Concomitant Hfd On I/rmentioning

confidence: 91%

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High fat diets alter aerobic exercise and L-arginine effects in ischemia reperfusion induced renal injury in rats: gender related difference

Vafamand¹,

Bolboli

JahaniAzizabadi³

et al. 2017

hmj

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Introduction: Renal ischemia reperfusion (I/R) caused kidney injury gender dependently. High fat diet (HFD) contributes the development of renal dysfunction. L-arginine (L-arg) and regular exercise are recognized to be protective in I/R and lipotoxicity. We compared the role of aerobic exercise and L-arg supplementation against renal I/R in male and female rats fed with HFD. Methods: 54 adult male and female Wistar rats received standard control diet (control), HFD, HFD plus L-arg (HFD±L-arg) or HFD plus aerobic exercise (HFD±EX) for 8 weeks. Then the animals were subjected to renal I/R by clamping renal vessels for period of 45 min followed by 24 hour reperfusion. Results: The serum levels of blood urea nitrogen (BUN) and creatinine (Cr), and kidney tissue damage score (KTDS) were not significantly different between HFD and control groups in two genders. However, the serum level of nitrite and kidney tissue level of malondialdehyde (MDA) in HFD fed male rats increased significantly (P<0.05). Also, kidney weight (KW) had significant decrement in HFD groups in comparison with control groups in two genders (P<0.05). L-arg and aerobic exercise decreased the BUN levels and KTDS in male rats after renal I/R (P<0.05), but such observations were not seen in female. Conclusion: These results indicated that L-arg and aerobic exercise could ameliorate renal I/R induced kidney injury in HFD male rats but not in female.

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Section: The Effect Of L-arg or Exercise Concomitant Hfd On I/rsupporting

confidence: 84%

Section: The Effect Of L-arg or Exercise Concomitant Hfd On I/rmentioning

confidence: 91%

High fat diets alter aerobic exercise and L-arginine effects in ischemia reperfusion induced renal injury in rats: gender related difference

Vafamand¹,

Bolboli

JahaniAzizabadi³

et al. 2017

hmj

Self Cite

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show abstract

“…In disagreement with our study, a study conducted by Yavari et al (2015) showed that exercise tends to increase oxidative stress due to higher oxygen consumption. Furthermore, Vafamand et al (2017) demostrated that exercise increased serum MDA and oxidative stress, because the antioxidant system was not adapted to excessive production of ROS due to I/R injury.…”

Section: Discussionmentioning

confidence: 99%

Effects of exercise and stevia on renal ischemia/reperfusion injury in rats [pdf]

Elsaid¹,

Khalil²,

Ibrahim³

et al. 2019

Acta Sci Pol Technol Aliment

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Background. The present work was designed to study the effects of methanolic stevia extracts and aerobic exercise and combination of both on renal I/R injury in male rats. Methods. 60 adult male Sprague-Dawley rats were subdivided into five equal groups as sham, control, exercise, stevia, and stevia plus exercise group. After 5 weeks of exercise and stevia, animals were exposed to 45 min of left renal ischemia and right nephrectomy followed by reperfusion. Serum creatinine, creatinine clearance, fractional Na excretion (FE Na +), malondialdehyde (MDA), reduced glutathione (GSH) and catalase (CAT) levels in kidney tissues were measured. Also, renal histopathology and the expression of caspase-3 by immunohistochemical examination were done. Results. The results showed that stevia, exercise or combination of stevia and exercise caused a significant decrease in serum level of creatinine (p < 0.001) and FE Na + (p < 0.001) and an increase in creatinine clearance (p < 0.001). Moreover, this caused a significant decrease in (MDA; p < 0.046) and an increase in GSH (p < 0.01) and CAT (p < 0.01), as well as causing a significant decrease in caspase 3 expression compared to the control group. Conclusion. Pretreatment with either stevia or exercise of combination of both seem to have protective effects on renal I/R injury. However, the protective effect of exercise against renal I/R injury seems to be less than stevia. These effects might be due to attenuation of oxidative stress and apoptosis in kidney tissues.

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The role of L-arginine and aerobic exercise in experimental renal ischemia reperfusion injury in male and female rats

Cited by 2 publications

References 3 publications

High fat diets alter aerobic exercise and L-arginine effects in ischemia reperfusion induced renal injury in rats: gender related difference

High fat diets alter aerobic exercise and L-arginine effects in ischemia reperfusion induced renal injury in rats: gender related difference

Effects of exercise and stevia on renal ischemia/reperfusion injury in rats [pdf]

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