The Role of Kv7 Channels in Neural Plasticity and Behavior

Baculis, Brian C.; Zhang, Jiaren; Chung, Hee Jung

doi:10.3389/fphys.2020.568667

Cited by 33 publications

(32 citation statements)

References 106 publications

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“…At the nucleus, UBE3A has been shown to regulate chromatin structure, DNA methylation and transcriptional regulation [37][38][39][40]. Interestingly, 8 out of the 10 genes found mutated in this study are mainly involved in synapsis (VAMP2, SYNGAP1, SLC6A1 and KCNQ3) [41][42][43][44] and chromatin remodeling or transcription regulation (TBL1XR1, SATB2, SMARCE1 and ASXL3) [45][46][47][48].…”

Section: Resultsmentioning

confidence: 95%

New genes involved in Angelman syndrome-like: Expanding the genetic spectrum

et al. 2021

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Angelman syndrome (AS) is a neurogenetic disorder characterized by severe developmental delay with absence of speech, happy disposition, frequent laughter, hyperactivity, stereotypies, ataxia and seizures with specific EEG abnormalities. There is a 10–15% of patients with an AS phenotype whose genetic cause remains unknown (Angelman-like syndrome, AS-like). Whole-exome sequencing (WES) was performed on a cohort of 14 patients with clinical features of AS and no molecular diagnosis. As a result, we identified 10 de novo and 1 X-linked pathogenic/likely pathogenic variants in 10 neurodevelopmental genes (SYNGAP1, VAMP2, TBL1XR1, ASXL3, SATB2, SMARCE1, SPTAN1, KCNQ3, SLC6A1 and LAS1L) and one deleterious de novo variant in a candidate gene (HSF2). Our results highlight the wide genetic heterogeneity in AS-like patients and expands the differential diagnosis.

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Section: Resultsmentioning

confidence: 95%

New genes involved in Angelman syndrome-like: Expanding the genetic spectrum

et al. 2021

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“…Although Kv7 channels have been suspected to be involved in functional plasticity (29), our study provides the first direct evidence for its involvement in activity-dependent intrinsic regulation of intrinsic excitability.…”

Section: Involvement Of Kv7 Channels In Intrinsic Plasticitymentioning

confidence: 73%

Long-lasting reduction of intrinsic excitability in O-LM interneurons is mediated by endocannabinoid-dependent up-regulation of Kv7 channels

Incontro

Sammari

Ankri

et al. 2021

Preprint

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KCNQ-Kv7 channels are found at the axon initial segment of pyramidal neurons where they control cell firing and membrane potential. In oriens lacunosum moleculare (O-LM) interneurons, these channels are mainly expressed in the dendrites, suggesting a peculiar function of Kv7 channels in these neurons. The physiology of Kv7 channels is well characterized today but the precise contribution of these channels to neuronal plasticity is still unknown. Here, we show that Kv7 channel activity is up-regulated following induction of presynaptic long-term synaptic depression (LTD) in O-LM interneurons, thus resulting in a synergistic long-term depression of intrinsic neuronal excitability (LTD-IE). Both LTD and LTD-IE involve endocannabinoid (eCB) biosynthesis for their induction. Molecular modeling shows strong interaction of eCBs with Kv7.2/3 channel, suggesting a persistent action of these lipids on Kv7 channel activity. Our data thus unveil a major role for eCB synthesis in triggering both synaptic and intrinsic depression in O-LM interneurons.

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“…Additionally, Cabello-Arreola et al [ 66 ] (2020) reported a reduction in the protein coded by KCNQ3 (potassium voltage-gated channel subfamily Q member 3) in suicide victims. This protein serves as a building block for the M-channel, a slow working potassium channel that is involved in the regulation of neuron excitability, which has previously been associated with epilepsy, attention deficit hyperactivity disorder, and psychiatric disorders[ 72 ].…”

Section: Use Of -Omics In Research Into Suicidal Behaviourmentioning

confidence: 99%

‘Omics’ of suicidal behaviour: A path to personalised psychiatry

Kouter¹,

Paska²

2021

WJP

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Psychiatric disorders, including suicide, are complex disorders that are affected by many different risk factors. It has been estimated that genetic factors contribute up to 50% to suicide risk. As the candidate gene approach has not identified a gene or set of genes that can be defined as biomarkers for suicidal behaviour, much is expected from cutting edge technological approaches that can interrogate several hundred, or even millions, of biomarkers at a time. These include the ‘-omic’ approaches, such as genomics, transcriptomics, epigenomics, proteomics and metabolomics. Indeed, these have revealed new candidate biomarkers associated with suicidal behaviour. The most interesting of these have been implicated in inflammation and immune responses, which have been revealed through different study approaches, from genome-wide single nucleotide studies and the micro-RNA transcriptome, to the proteome and metabolome. However, the massive amounts of data that are generated by the ‘-omic’ technologies demand the use of powerful computational analysis, and also specifically trained personnel. In this regard, machine learning approaches are beginning to pave the way towards personalized psychiatry.

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The Role of Kv7 Channels in Neural Plasticity and Behavior

Cited by 33 publications

References 106 publications

New genes involved in Angelman syndrome-like: Expanding the genetic spectrum

New genes involved in Angelman syndrome-like: Expanding the genetic spectrum

Long-lasting reduction of intrinsic excitability in O-LM interneurons is mediated by endocannabinoid-dependent up-regulation of Kv7 channels

‘Omics’ of suicidal behaviour: A path to personalised psychiatry

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