The role of kidney dysfunction in COVID-19 and the influence of age

Porta, Edoardo La; Baiardi, Paola; Fassina, Lorenzo; Faragli, Alessandro; Perna, Simone; Tovagliari, Federico; Tallone, Ilaria; Talamo, Giuseppina; Secondo, G; Mazzarello, Giovanni; Esposito, Vittoria; Pasini, M.; Lupo, Fabio; Bassetti, Matteo; Esposito, Ciro

doi:10.1038/s41598-022-12652-0

Cited by 11 publications

(12 citation statements)

References 28 publications

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“…Kidney dysfunction is a common consequence of SARS-CoV-2 infection ( 1 , 2 ), having been reported in adults and, to a lesser degree, in children. Kidney consequences of COVID-19 can include a broad spectrum of damages, ranging from acute kidney injury (AKI) with glomerular or tubular injury to mild proteinuria and/or hematuria ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Case Report: Multisystem inflammatory syndrome in children with associated proximal tubular injury

et al. 2023

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IntroductionSARS-CoV-2 infection in the pediatric population can be associated with a multiorgan inflammatory syndrome called children’s multisystem inflammatory syndrome (MIS-C). The kidneys can be affected by a broad spectrum of possible injuries, whose pathogenetic mechanisms are still unclear.Case reportWe report the case of a 5-year-old boy with severe cardiac involvement in the context of MIS-C. After two weeks of hospitalization, an abdominal ultrasound showed massive bladder “debris”, followed by the onset of normoglycemic glycosuria. Over time, there was a progressive increase in glycosuria, and the presence of a mat of amorphous phosphate crystals was evidenced on urinary sediment. Together with the findings of hypo-uricemia, increased urinary uric acid, and globally increased urinary amino acids, a clinical picture of kidney proximal tubular damage with secondary Fanconi-like syndrome took shape.DiscussionThis case report describes the case of a patient with MIS-C with cardiac and kidney involvement characterized by proximal tubular damage, which slowly improved but still persisted at the 8-month follow-up. The pathogenesis of the damage is unclear and probably multifactorial.

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Section: Introductionmentioning

confidence: 99%

Case Report: Multisystem inflammatory syndrome in children with associated proximal tubular injury

et al. 2023

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“…Similarly, both the brain-specific and kidney-specific models could predict disease severity. Acute kidney injury is a common occurrence in COVID-19 patients (La Porta et al, 2022), and severe COVID has been linked to accelerated brain aging (Mavrikaki et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Plasma-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems

Goeminne,

Eames,

Tyshkovskiy

et al. 2024

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Aging is a complex process manifesting at the molecular, cell, organ and organismal levels. It leads to functional decline, disease and ultimately death, but the relationship between these fundamental biomedical features remains unclear. By applying machine learning to plasma proteome data of over fifty thousand human subjects in the UK Biobank, we report organ-specific and conventional aging models trained on chronological age, mortality and longitudinal proteome data. We show how these tools help uncover the basis for health and disease through numerous phenotypes. We find that men are biologically older and age faster than women, that accelerated aging of organs leads to diseases in these organs, and that diets, lifestyles, professions and medications are associated with accelerated and decelerated organ aging. Altogether, our analyses reveal that age-related chronic diseases epitomize accelerated organ- and system-specific aging, modifiable through environmental factors, advocating for both universal whole-organism and personalized organ/system-specific anti-aging interventions.

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“…Some other studies demonstrated that chronic inflammation, a salient feature in HD patients, might protect those patients from severe COVID-19-related symptoms, ICU admission, and mortality [ 9 , 16 ]. These discordant results are accepted because of the limitations known in the observational studies and multiple confounders which can affect the patient prognosis like age [ 37 ], associated comorbidities, and selection bias. The present study revealed a better survival rate, less severe hypoxemia indicating hospital or ICU admission in COV-HD than COV patients despite the comparable age, comorbidity, radiological severity criteria.…”

Section: Discussionmentioning

confidence: 99%

Characterization of regulatory T cells in SARS-CoV-2 infected hemodialysis patients: relation to clinical and radiological severity

et al. 2022

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Background Disordered Treg counts and function have been observed in patients with SARS-Cov-2 and are thought to contribute to disease severity. In hemodialysis patients, scarce data are available on the Treg response to SARS-CoV-2 or its relation to the clinical presentation. Methods A cross-sectional study included one hundred patients divided into three groups, thirty SARS-CoV-2-infected hemodialysis patients (COV-HD), and thirty confirmed SARSCoV-2 infected patients (COV), and forty non-infected hemodialysis patients (HD). Flow cytometric analysis of CD4, CD25, FoxP3, and CD39+ Tregs was done for all patients and tested for correlation to in-hospital mortality, clinical, radiological severity indices. Results COV-HD and COV patients had significantly lower Treg cell count than HD patients (Median value of 0.016 cell/ μl vs 0.28 cell/ μl, respectively- P: 0.001). COV-HD patients had higher CD39+ Tregs (median value of 0.006 cell/ μl vs 0.002 cell/ μl, respectively- P: 0.04). COV-HD patients had significantly lower hospital stay (median value of 3 vs 13 days, P:0.001), ICU admission rates (26.5% vs 46.7%, P:0.005) and in-hospital mortality (20.7% versus 43.3%, P:0.003) than COV patients. Treg and CD39 expressing Treg counts were not correlated to severity indices in both groups. A high neutrophil to lymphocyte ratio is strongly correlated to disease severity in COV-HD patients. Conclusions This study provides evidence of T-cell, particularly T-regulatory cell decline in SARS-CoV-2 and suggests that hemodialysis per se does not distinctively impact the T-cell response. COV-HD patients exhibited a higher CD39+ Treg count and a better clinical profile, however, larger studies are needed to extrapolate on these findings.

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The role of kidney dysfunction in COVID-19 and the influence of age

Cited by 11 publications

References 28 publications

Case Report: Multisystem inflammatory syndrome in children with associated proximal tubular injury

Case Report: Multisystem inflammatory syndrome in children with associated proximal tubular injury

Plasma-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems

Characterization of regulatory T cells in SARS-CoV-2 infected hemodialysis patients: relation to clinical and radiological severity

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