The role of ketone bodies in caloric homeostasis

Whole-body autoradiographic study on the distribution of (U-14C)galactose in adult, pregnant, newborn and infant mice.

“…The utilization of exogeneous galactose in the brain of fetal and newborn mice is still uncertain. Such low radioactivity in the brain of fetal and newborn mice may be related to the fact that the ketone body is the major metabolic fuel in the suckling period (11,17,23,28,29,37). As stated above, radioactivity in the brain increased from 3 weeks after the birth.…”

Comparative studies on 3-oxo acid coenzyme A transferase from various rat tissues

“…The studies by Krebs, Williamson and their colleagues have helped to undermine the notion that the ketone bodies, acetoacetate and 3-hydroxybutyrate, are useless metabolic products by demonstrating that they serve as major fuels of respiration for all tissues except liver (for reviews see Krebs et al, 1971;Williamson & Hems, 1970). The function of succinylCoA-3-oxo acid CoA transferase in this metabolism, namely to produce the activated acetoacetyl-CoA derivative, has been amply demonstrated by these and other investigators (Jencks, 1973;Tildon & Sevdalian, 1972).…”

Should animal fats be back on the table? A critical review of the human health effects of animal fat

“…The ketone bodies b-hydroxybutyrate and acetoacetate are deliberately generated from FA and are not a consequence of incomplete glucose metabolism via the tricarboxylic acid cycle (Krebs 1966;Krebs et al 1971). These are a form of energy from fat that is directly soluble in aqueous solution rather than either being carried as NEFA attached to albumin or TAG carried via serum cholesterol or chylomicrons, and are the only metabolite from FA that can be directly metabolised by the brain (Cahill 2006).…”