The Role of KEAP1-NRF2 System in Atopic Dermatitis and Psoriasis

Ogawa, Tatsuya; Ishitsuka, Yosuke

doi:10.3390/antiox11071397

Cited by 20 publications

(10 citation statements)

References 121 publications

(173 reference statements)

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“…Nrf2 prevents or protects against oxidative stress-mediated cellular damage and promotes the expressions of antioxidant-related factors, such as HO-1 [ 46 ]. Moreover, the Nrf2/HO-1 signaling pathway provides a defense mechanism that regulates chronic inflammatory responses induced by oxidative stress [ 47 , 48 , 49 ]. Previous studies suggest that the activation of the Nrf2/HO-1 pathway enhances the inflammatory response and epidermal homeostasis from oxidative stress in hapten-induced AD mice [ 47 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the Nrf2/HO-1 signaling pathway provides a defense mechanism that regulates chronic inflammatory responses induced by oxidative stress [ 47 , 48 , 49 ]. Previous studies suggest that the activation of the Nrf2/HO-1 pathway enhances the inflammatory response and epidermal homeostasis from oxidative stress in hapten-induced AD mice [ 47 , 50 ]. In our study, the topical application of NPR extract increased the expressions of the antioxidant enzymes pNrf2, Nrf2, and HO-1, which regulate DNCB-induced excessive oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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Nymphoides peltata Root Extracts Improve Atopic Dermatitis by Regulating Skin Inflammatory and Anti-Oxidative Enzymes in 2,4-Dinitrochlorobenzene (DNCB)-Induced SKH-1 Hairless Mice

et al. 2023

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Nymphoides peltata is widely used pharmacologically in Traditional Chinese Medicine and Ayurvedic medicine as a diuretic, antipyretic, or choleretic and to treat ulcers, snakebites, and edema. Previous studies have shown that phytochemicals from N. peltata have physiological activities such as anti-inflammatory, anti-tumor, and anti-wrinkle properties. Nevertheless, research on the anti-atopic dermatitis (AD) effect of N. peltata extract is limited. This study was undertaken to assess the in vitro and in vivo anti-atopic and antioxidant activities of a 95% EtOH extract of N. peltata roots (NPR). PI-induced RBL-2H3 cells and two typical hapten mice (oxazolone-induced BALB/c mice and 2,4-dinitrochlorobenzene (DNCB)-induced SKH-1 hairless mice) were used to investigate the effect of NPR extract on AD. The expressions of AD-related inflammatory cytokines, skin-related genes, and antioxidant enzymes were analyzed by ELISA, immunoblotting, and immunofluorescence, and skin hydration was measured using Aquaflux AF103 and SKIN-O-MAT instruments. The chemical composition of NPR extract was analyzed using an HPLC-PDA system. In this study, NPR extracts were shown to most efficiently inhibit IL-4 in PI-induced RBL-2H3 cells and AD-like skin symptoms in oxazolone-BALB/c mice compared to its whole and aerial extracts. NPR extract markedly reduced DNCB-induced increases in mast cells, epidermal thickness, IL-4 and IgE expressions, and atopic-like symptoms in SKH-1 hairless mice. In addition, NPR extract suppressed DNCB-induced changes in the expressions of skin-related genes and skin hydration and activated the Nrf2/HO-1 pathway. Three phenolic acids (chlorogenic acid, 3,5-dicaffeoylquinic acid, and 3,4-dicaffeoylquinic acid) were identified by HPLC-PDA in NPR extract. The study shows that NPR extract exhibits anti-atopic activities by inhibiting inflammatory and oxidative stress and improving skin barrier functions, and indicates that NPR extract has potential therapeutic use for the prevention and treatment of AD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nymphoides peltata Root Extracts Improve Atopic Dermatitis by Regulating Skin Inflammatory and Anti-Oxidative Enzymes in 2,4-Dinitrochlorobenzene (DNCB)-Induced SKH-1 Hairless Mice

et al. 2023

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“…62 Activation of Nrf2 may improve inflammatory signalling in human keratinocytes in vitro and the phenotype of sensitizer-induced skin inflammation in AD mouse models. 63 NLRP3 inflammasome plays a vital role in the development of AD, and the activation of NLRP3 inflammasome induces AD. 42 Many studies have proven that suppressing NLRP3 inflammasome contributes to the mitigation of AD.…”

Section: Discussionmentioning

confidence: 99%

“…Upregulation of Nrf2 contributes to the inhibition of Th2 cytokine production and oxidative damage in AD mice 62 . Activation of Nrf2 may improve inflammatory signalling in human keratinocytes in vitro and the phenotype of sensitizer‐induced skin inflammation in AD mouse models 63 . NLRP3 inflammasome plays a vital role in the development of AD, and the activation of NLRP3 inflammasome induces AD 42 .…”

Section: Discussionmentioning

confidence: 99%

Esculentoside A ameliorates DNCB‐induced atopic dermatitis by suppressing the ROS‐NLRP3 axis via activating the Nrf2 pathway

Liu

Liao

2023

Clin Exp Pharma Physio

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Atopic dermatitis (AD) is a chronic inflammatory skin condition with a high prevalence. Inflammation and oxidative stress are strongly associated with AD progression. Esculentoside A (EsA) inhibits inflammation and oxidative stress in various diseases. However, whether EsA mitigates AD by suppressing inflammation and oxidative stress remains unknown. A mouse model of AD was constructed by the induction of 1‐chloro‐2,4‐dinitrochlorobenzene (DNCB). The mechanism of EsA and its effects on AD symptoms, pathology, inflammation and oxidative stress were investigated through histopathological staining, enzyme‐linked immunosorbent assay, blood cells analysis, colorimetric measurement and western blot analysis. EsA improved the clinical symptoms and increased clinical skin scores in AD mice. Skin thickening of the epidermis and dermal tissues and the mast cell numbers in AD mice were reduced with the EsA treatment. EsA decreased the relative mRNA level of thymic stromal lymphopoietin, interleukin (IL)‐4, IL‐5 and IL‐13; the serum concentrations of immunoglobulin E (IgE) and IL‐6; and the numbers of white blood cells (WBC) and WBC subtypes, including basophil, lymphocytes, eosinophil, neutrophil and monocytes in DNCB‐induced mice. DNCB caused higher levels of oxidative stress, which was reversed with the administration of EsA. Mechanically, EsA upregulated the expression of Nrf2 but downregulated the level of NLRP3 inflammasome in AD mice. The inhibitor of Nrf2 significantly recovered the EsA‐induced changes in the NLRP3 inflammasome proteins in DNCB‐treated mice. Therefore, EsA improved the clinical and pathological symptoms, inflammation and oxidative stress experienced by DNCB‐induced mice and was involved in the inactivation of NLRP3 inflammasome by activating Nrf2.

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“…This results in a significant resistance at cellular levels to a subsequent highly lethal dose of oxidants. Recently, Ogawa and Ishitsuka [ 275 ] reviewed the role of Keap1-Nrf2 system in the pathophysiology of atopic dermatitis and psoriasis and the therapeutic approaches that utilize this system.…”

Section: Discussionmentioning

confidence: 99%

On the Potential Role of the Antioxidant Couple Vitamin E/Selenium Taken by the Oral Route in Skin and Hair Health

Pincemaïl¹,

Meziane²

2022

Antioxidants

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The relationship between oxidative stress and skin aging/disorders is well established. Many topical and oral antioxidants (vitamins C and E, carotenoids, polyphenols) have been proposed to protect the skin against the deleterious effect induced by increased reactive oxygen species production, particularly in the context of sun exposure. In this review, we focused on the combination of vitamin E and selenium taken in supplements since both molecules act in synergy either by non-enzymatic and enzymatic pathways to eliminate skin lipids peroxides, which are strongly implicated in skin and hair disorders.

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The Role of KEAP1-NRF2 System in Atopic Dermatitis and Psoriasis

Cited by 20 publications

References 121 publications

Nymphoides peltata Root Extracts Improve Atopic Dermatitis by Regulating Skin Inflammatory and Anti-Oxidative Enzymes in 2,4-Dinitrochlorobenzene (DNCB)-Induced SKH-1 Hairless Mice

Nymphoides peltata Root Extracts Improve Atopic Dermatitis by Regulating Skin Inflammatory and Anti-Oxidative Enzymes in 2,4-Dinitrochlorobenzene (DNCB)-Induced SKH-1 Hairless Mice

Esculentoside A ameliorates DNCB‐induced atopic dermatitis by suppressing the ROS‐NLRP3 axis via activating the Nrf2 pathway

On the Potential Role of the Antioxidant Couple Vitamin E/Selenium Taken by the Oral Route in Skin and Hair Health

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