The role of itch and pain modulation in the prediction of phototherapy outcomes: a prospective cohort study

Ramon, Michal; Yakov, Sarit; Kuperman, Pora; Granot, Michal

doi:10.1080/09546634.2020.1800572

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…Hence, we explored, in chronic itch patients, whether itch symptoms and pain perception are affected by psycho-cognitive parameters of catastrophizing thinking for both itch and pain. Patients (n = 59) with psoriasis, atopic dermatitis or dry skin disorders with itch of ≥4 (0-10 itch numerical rating scale) and minimum of two daily itch episodes per week 7,8 were included. Itch degree was defined as the mean of itch intensity, frequency and duration.…”

Section: Catastrophizing Thinking Towards Itch and Pain In Chronic Itmentioning

confidence: 99%

Catastrophizing thinking towards itch and pain in chronic itch patients

Granot

Yakov

Kuperman

et al. 2020

Acad Dermatol Venereol

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Section: Catastrophizing Thinking Towards Itch and Pain In Chronic Itmentioning

confidence: 99%

Catastrophizing thinking towards itch and pain in chronic itch patients

Granot

Yakov

Kuperman

et al. 2020

Acad Dermatol Venereol

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“…Third, results call for further exploration of the involvement of different neuronal pathways and contribution of central sensitization processes in the various itch profiles, that may pave the way to conduct targeted medication clinical trials. For example, psychophysically assessing itch and pain modulation may predict course of symptoms and therapeutic (e.g., post-operative) outcomes for both chronic itch and pain ( 47 , 48 ).…”

Section: Discussionmentioning

confidence: 99%

Role of burn severity and posttraumatic stress symptoms in the co-occurrence of itch and neuropathic pain after burns: A longitudinal study

et al. 2022

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Itch and pain are common after burns. Neuropathic mechanisms may underlie both modalities but remain not well-understood. This study aims to prospectively document neuropathic pain symptoms and to identify potential itch symptom profiles that differ regarding duration and co-occurrence with neuropathic pain which may inform underlying pathophysiological mechanisms and respond to different treatments. Adult burn survivors (n = 192) self-reported itch and neuropathic pain at 2 weeks post-discharge, 3, 6, 12, and 18 months post-burn. Based on the presence of itch and pain symptoms over time, participants were allocated to one itch profile: transient itch/pain, chronic itch, or chronic itch & pain. Profiles were compared on itch intensity over time using General Linear Modeling. Age, gender, burn severity, posttraumatic stress (PTS) symptoms and baseline itch intensity were examined as potential predictors of the profiles in a Multi-nominal regression analysis. Neuropathic pain occurred in 54% after discharge which decreased to 24% 18 months later. Itch intensity was highest in the chronic itch & pain profile. Compared to the transient itch profile, the chronic itch & pain profile was associated with higher burn severity and more PTS symptoms. Compared to the chronic itch profile, the chronic itch & pain profile was associated with more PTS symptoms. Findings suggest that biological and psycho-dermatological processes underlie both chronic neuropathic pain and itch processes in burn scars. Further research should elucidate the mechanisms underlying the different itch profiles, with specific focus on skin innervation and psychological factors.

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The role of itch and pain modulation in the prediction of phototherapy outcomes: a prospective cohort study

Cited by 2 publications

References 28 publications

Catastrophizing thinking towards itch and pain in chronic itch patients

Catastrophizing thinking towards itch and pain in chronic itch patients

Role of burn severity and posttraumatic stress symptoms in the co-occurrence of itch and neuropathic pain after burns: A longitudinal study

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