The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer

Pejcic, T.; Zeković, Milica; Bumbaširević, Uroš; Kalaba, Milica; Vovk, Irena; Bensa, Maja; Popović, Lazar; Tešić, Živoslav

doi:10.3390/antiox12020368

Cited by 15 publications

(9 citation statements)

References 169 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aglycones are particularly important due to their higher phytoestrogenic activity and better absorption in the human body (Nielsen & Williamson, 2007). Genistein and daidzein have been linked to potential prevention of hormone‐related cancers, such as prostate and breast cancer (Pejčić et al ., 2023). Our interesting result is that the glycoside form of glycitin, daidzein and genistein were under the limit of detection while their different derivatives dominated the metabolomes.…”

Section: Resultsmentioning

confidence: 98%

Single‐grain‐based widely targeted metabolomics profiling of sixty‐four accessions of Japanese wild soybean (Glycin soja Sieb. Et Zucc.)

Nguyen

Dang

et al. 2023

Int J of Food Sci Tech

View full text Add to dashboard Cite

SummarySoybean (Glycine max L. Merr.) is a major crop worldwide, providing essential dietary proteins and edible oils for agriculture, food, animal feed, and biofuel industries. However, its limited genetic variation makes it vulnerable to harsh environmental conditions, and its chemical diversity was strongly reduced after long domestication. Wild soybean (Glycine soja Sieb. et Zucc.), the ancestor of the G. max, possesses a high level of genetic diversity and thus present a precious reservoir for improving cultivated soybean. Characterizing metabolomes of different G. soja accessions is crucial in exploring metabolite accumulation patterns for developing metabolic breeding strategies. This study successfully revealed the metabolomes of 64 seed lines of G. soja collected throughout Japan by a widely targeted metabolomics approach, therefore providing a good source of information for further studies to induce the production of bioactive compounds and the defense mechanism to stress.

show abstract

Section: Resultsmentioning

confidence: 98%

Single‐grain‐based widely targeted metabolomics profiling of sixty‐four accessions of Japanese wild soybean (Glycin soja Sieb. Et Zucc.)

Nguyen

Dang

et al. 2023

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…In the plasma and prostatic fluid of Hong Kong men, higher concentrations of isoflavones were observed compared to those from Portugal and Britain [ 12 ]. Pejčić et al [ 13 ] proposed that the presence of soy isoflavones, found in significant levels in the prostatic fluid of Asian men, might offer protection against various prostate disorders. However, a study involving 81 older healthy men showed no statistically significant differences in prostate-specific antigen (PSA) levels after 1 year of consuming a soy protein drink [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Chickpea Sprouts as a Potential Dietary Support in Different Prostate Disorders—A Preliminary In Vitro Study

Galanty,

Prochownik,

Grudzińska

et al. 2024

Molecules

View full text Add to dashboard Cite

Background: Prostate cancer (PC) and benign prostatic hyperplasia (BPH) are common health problems in the aging male population. Due to the unexplored and unconfirmed impact of food containing isoflavones, like sprouts, on the development of the management of BPH and prostate cancer, we decided to extend the knowledge in this area. Results: We have demonstrated for the first time that chickpea sprouts may play an important role in the chemoprevention of prostate disorders. However, attention should be paid to the isoflavone content in the sprouts, as in our study, chickpea sprouts with a moderate concentration of the compounds, harvested in natural light conditions (CA10L) and blue LED light (CA7B), showed the best scores in terms of their potential towards prostate disorders. Methods: Chickpea seeds were grown in LED chambers. The methanol extracts from sprouts were quantitatively defined using the HPLC system. Experiments such as the determination of PSA, 5-α-reductase, and dihydrotestosterone were performed on PNT2 and LNCaP cells. For anti-inflammatory assays (determination of NO, IL-6, and TNF-alpha release), murine RAW264.7 macrophages were used. Conclusions: The role of legume products as a diet element should be deeply evaluated for the development of future dietary recommendations for prostate cancer and BPH prevention.

show abstract

“…On the other hand, combined treatment with doxorubicin and formononetin reversed the EMT process in U87MG glioma cells by decreasing vimentin expression and increasing E-cadherin expression ( Quan et al, 2015 ). The mode of action of isoflavonoids is by blocking TGF-β/IRS, EGF/EGFR, FAK/Paxillin, MAPK, IκB, PI3K/Akt ERK, STAT3, FAK, and Src-mediated signaling pathways ( Javed et al, 2021 ; Li et al, 2011 ; Pejčić et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Regulation of cellular and molecular markers of epithelial-mesenchymal transition by Brazilin in breast cancer cells

Cayetano-Salazar,

Hernandez-Moreno,

Bello-Martinez

et al. 2024

PeerJ

View full text Add to dashboard Cite

Breast cancer is the most common invasive neoplasm and the leading cause of cancer death in women worldwide. The main cause of mortality in cancer patients is invasion and metastasis, where the epithelial-mesenchymal transition (EMT) is a crucial player in these processes. Pharmacological therapy has plants as its primary source, including isoflavonoids. Brazilin is an isoflavonoid isolated from Haematoxilum brasiletto that has shown antiproliferative activity in several cancer cell lines. In this study, we evaluated the effect of Brazilin on canonical markers of EMT such as E-cadherin, vimentin, Twist, and matrix metalloproteases (MMPs). By Western blot, we evaluated E-cadherin, vimentin, and Twist expression and the subcellular localization by immunofluorescence. Using gelatin zymography, we determined the levels of secretion of MMPs. We used Transwell chambers coated with matrigel to determine the in vitro invasion of breast cancer cells treated with Brazilin. Interestingly, our results show that Brazilin increases 50% in E-cadherin expression and decreases 50% in vimentin and Twist expression, MMPs, and cell invasion in triple-negative breast cancer (TNBC) MDA-MB-231 and to a lesser extend in MCF7 ER+ breast cancer cells. Together, these findings position Brazilin as a new molecule with great potential for use as complementary or alternative treatment in breast cancer therapy in the future.

show abstract

The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer

Cited by 15 publications

References 169 publications

Single‐grain‐based widely targeted metabolomics profiling of sixty‐four accessions of Japanese wild soybean (Glycin soja Sieb. Et Zucc.)

Single‐grain‐based widely targeted metabolomics profiling of sixty‐four accessions of Japanese wild soybean (Glycin soja Sieb. Et Zucc.)

Chickpea Sprouts as a Potential Dietary Support in Different Prostate Disorders—A Preliminary In Vitro Study

Regulation of cellular and molecular markers of epithelial-mesenchymal transition by Brazilin in breast cancer cells

Contact Info

Product

Resources

About