The role of iron in an acute model of skin inflammation induced by reactive oxygen species (ROS)

Trenam, Charles W.; Dabbagh, Alya; Blake, David R.; Morris, Christopher J.

doi:10.1111/j.1365-2133.1992.tb00654.x

Cited by 26 publications

(19 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here too there is clear evidence for the involvement of a deranged iron metabolism [1343-1345]. Early attempts at therapy with a series of unusual iron chelators (that unfortunately had side effects) [1346] do not seem to have been followed up.…”

Section: Some Disease Manifestations In Which Iron May Be Implicatedmentioning

confidence: 99%

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

2009

View full text Add to dashboard Cite

Background: The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular 'reactive oxygen species' (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation.

show abstract

Section: Some Disease Manifestations In Which Iron May Be Implicatedmentioning

confidence: 99%

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

2009

View full text Add to dashboard Cite

show abstract

“…To investigate the proinflammatory effects of BaP on NHEKs, we focused on ROS production because it occurs via the metabolizing process of BaP by CYP1A1 [4,28] and there is compelling evidence that ROS drives the production of oxidative products, which can denature proteins and influence the release of proinflammatory cyto/chemokines, which may be critical for the induction of some inflammatory skin diseases [8,9,17,29]. Furthermore, it is also recognized that ROS can act as a second messenger in the initiation of signal transduction, such as the activation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) or AP-1 (activator protein 1) and the production of proinflammatory cyto/ chemokines [30].…”

Section: [ ( ) T D $ F I G ]mentioning

confidence: 99%

An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway

Tsuji

Takahara

Uchi

et al. 2011

Journal of Dermatological Science

137

160

View full text Add to dashboard Cite

“…The main source of ROS is in¯ammatory cellular in®ltrate. Stimulated monocytes produce superoxide, the respiratory burst of in®ltrating PMN in in¯amed skin will produce high local levels of superoxide anion and hydrogen peroxide (Trenam et al, 1992a;Darr and Fridovich, 1994). Production of nitric oxide by nitric oxide synthase in keratinocytes also occurs (Halliwell and Gutteridge, 1999).…”

mentioning

confidence: 99%

Patients with Allergic and Irritant Contact Dermatitis are Characterized by Striking Change of Iron and Oxidized Glutathione Status in Nonlesional Area of the Skin

Kaur

Zilmer

Eisen

et al. 2001

Journal of Investigative Dermatology

View full text Add to dashboard Cite

To assess the consequences of oxidative stress in allergic and irritant contact dermatitis, we compared the iron level, unsaturated iron-binding capacity, total iron binding capacity, the percentage saturation of iron-binding capacity, the amount of diene conjugates as well as the amounts of total glutathione, reduced glutathione, oxidized glutathione, and the oxidized glutathione/reduced glutathione ratio in skin homogenate from lesional and nonlesional skin. Lesional skin samples were obtained from positive patch test sites to 5% NiSO4 in five subjects, and from chronic contact dermatitis lesions on the hands, which had exacerbated over 3--9 wk in six subjects. Contact dermatitis caused at least a 4-fold increase in the iron level in the lesional skin area compared with the nonlesional skin area (p < 0.02). The increase in the iron level depended on the duration of contact dermatitis and was accompanied by high unsaturated iron-binding capacity and total iron-binding capacity values in the positive patch test sites (p < 0.05), and by a high percentage saturation value in the chronic contact dermatitis lesions (p < 0.05). We found high indices for iron, total iron-binding capacity and diene conjugates in the apparently healthy skin of the patients with persistent contact dermatitis that significantly (p < 0.05) exceeded the corresponding values in the patients with only patch test reactions. In summary, we have succeeded in providing evidence that generalized oxidative damage of the skin occurs as a consequence of contact dermatitis in a restricted area.

show abstract

The role of iron in an acute model of skin inflammation induced by reactive oxygen species (ROS)

Cited by 26 publications

References 40 publications

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway

Patients with Allergic and Irritant Contact Dermatitis are Characterized by Striking Change of Iron and Oxidized Glutathione Status in Nonlesional Area of the Skin

Contact Info

Product

Resources

About