The Role of IP3 Receptor Channel Clustering in Ca2+ Wave Propagation During Oocyte Maturation

Ullah, Aman; Jung, P.; Ullah, Ghanim; Machaca, Khaled

doi:10.1016/b978-0-12-397897-4.00006-1

Cited by 7 publications

(13 citation statements)

References 23 publications

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“…In Xenopus, InsP 3 can produce a much faster (23 m/s) Ca 2+ wave in immature oocytes than in the mature eggs (8 m/s), although its peak amplitude may be lower [58]. Several hypotheses were set forth to explain the changes in the speed of wave propagation in Xenopus oocytes, including the one based on clustering of InsP 3 receptors, but the issue is still a matter of speculation [59].…”

Section: Discussionmentioning

confidence: 99%

Novel Ca2+ increases in the maturing oocytes of starfish during the germinal vesicle breakdown

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Novel Ca2+ increases in the maturing oocytes of starfish during the germinal vesicle breakdown

et al. 2015

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“…During this transition, ∼50% of the IP 3 R1 mass is lost through ligand-induced degradation (Parrington et al 1998;Jellerette et al 2000). Likewise, the organization of IP 3 R1s is affected as the ER changes from a predominantly cortical and clustered organization at the MII stage, which is believed to enhance IP 3 R1's sen-sitivity (Ullah et al 2014), to a more homogenous distribution that modifies the channel's properties (FitzHarris et al 2003). Phosphorylation also affects IP 3 R1 function in eggs.…”

Section: The Ca 2+ Toolkit In Mammalian Oocytes/eggsmentioning

confidence: 99%

Ca²⁺Signaling and Homeostasis in Mammalian Oocytes and Eggs

Wakai

Mehregan

Fissore

2019

Cold Spring Harb Perspect Biol

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Changes in the intracellular concentration of calcium ([Ca 2+ ] i) represent a vital signaling mechanism enabling communication between and among cells as well as with the environment. Cells have developed a sophisticated set of molecules, "the Ca 2+ toolkit," to adapt [Ca 2+ ] i changes to specific cellular functions. Mammalian oocytes and eggs, the subject of this review, are not an exception, and in fact the initiation of embryo devolvement in all species is entirely dependent on distinct [Ca 2+ ] i responses. Here, we review the components of the Ca 2+ toolkit present in mammalian oocytes and eggs, the regulatory mechanisms that allow these cells to accumulate Ca 2+ in the endoplasmic reticulum, release it, and maintain basal and stable cytoplasmic concentrations. We also discuss electrophysiological and genetic studies that have uncovered Ca 2+ influx channels in oocytes and eggs, and we analyze evidence supporting the role of a sperm-specific phospholipase C isoform as the trigger of Ca 2+ oscillations during mammalian fertilization including its implication in fertility. A n increase in the intracellular concentration of calcium ([Ca 2+ ] i) underlies the initiation, progression, and/or completion of a wide variety of cellular processes, including fertilization, muscle contraction, secretion, cell division, and apoptosis (Berridge et al. 2000, 2003; Clapham 2007). For Ca 2+ to perform these duties, cells create and maintain ionic gradients between extracellular and intracellular milieus and within the cellular content, thereby rendering this divalent ion into a signaling messenger. Cells have at their disposal a myriad of proteins with different affinities to bind Ca 2+ , which allows them to interpret and transform these elevations into cellular functions. This review will examine how mammalian oocytes and eggs, namely mouse gametes, which are the most widely studied, have adopted and adapted a variety of molecules involved in establishing cellular Ca 2+ homeostasis, the "Ca 2+ toolkit," to serve their precise physiological functions. These include the processes of maturation, fertilization, and embryo development until the birth of an offspring. In the egg, the activating Ca 2+ signal that initiates development has been broadly studied in many mammalian and nonmammalian species (Miyazaki 2006

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“…The major events of calcium signaling differentiation during maturation include internalization of the plasma membrane calcium ATPase, loss of store-operated calcium entry and spatial reorganization of IP3 receptors in the ER membrane [68,69,70,71]. Recently, computational modeling demonstrated that jointly, these factors can account for the observed changes in calcium signaling wave propagation [72]. …”

Section: Generation Of Calcium Transient In Xenopus Egg At Fertilimentioning

confidence: 99%

Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg

Tokmakov

Стефанов

Iwasaki

et al. 2014

IJMS

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Calcium is a universal messenger that mediates egg activation at fertilization in all sexually reproducing species studied. However, signaling pathways leading to calcium generation and the mechanisms of calcium-induced exit from meiotic arrest vary substantially among species. Here, we review the pathways of calcium signaling and the mechanisms of meiotic exit at fertilization in the eggs of the established developmental model, African clawed frog, Xenopus laevis. We also discuss calcium involvement in the early fertilization-induced events in Xenopus egg, such as membrane depolarization, the increase in intracellular pH, cortical granule exocytosis, cortical contraction, contraction wave, cortical rotation, reformation of the nuclear envelope, sperm chromatin decondensation and sister chromatid segregation.

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The Role of IP3 Receptor Channel Clustering in Ca2+ Wave Propagation During Oocyte Maturation

Cited by 7 publications

References 23 publications

Novel Ca2+ increases in the maturing oocytes of starfish during the germinal vesicle breakdown

Novel Ca2+ increases in the maturing oocytes of starfish during the germinal vesicle breakdown

Ca²⁺Signaling and Homeostasis in Mammalian Oocytes and Eggs

Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg

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The Role of IP3 Receptor Channel Clustering in Ca2+ Wave Propagation During Oocyte Maturation

Cited by 7 publications

References 23 publications

Novel Ca2+ increases in the maturing oocytes of starfish during the germinal vesicle breakdown

Novel Ca2+ increases in the maturing oocytes of starfish during the germinal vesicle breakdown

Ca2+Signaling and Homeostasis in Mammalian Oocytes and Eggs

Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg

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Product

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Ca²⁺Signaling and Homeostasis in Mammalian Oocytes and Eggs