The Role of Ions in Thermoregulation and Fever

Myers, R.D.

doi:10.1007/978-3-642-68569-9_7

Cited by 28 publications

(3 citation statements)

References 66 publications

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“…Corresponding studies show that the level of IL-6 increases after an endotoxin challenge in both plasma and hypothalamus, which can correlate with the shift in T, of the mouse or rat (Engelberts et al, 1991;Gottschall et al, 1992;Roth et al, 1992). The fact that IL-1 given ICV also augments the circulating level of IL-6 (DeSimoni et al, 1990) implies that a part of the acute phase response to other pyrogenic cy- Myers et al, 1974) but comprise a primary link in the integration of temperature signals within the thermoregulatory pathways (Boulant, 1991 ;Myers, 1982;Myers and Lee, 1989). This anatomical homology within the AH/POA and the congruence of thermogenic effects of both IL-6 and MIP-1P collectively suggest that the two cytokines may share either a common mechanism of action, or a common pathway for the induction of fever, or both.…”

Section: Discussionmentioning

confidence: 99%

Fever and feeding in the rat: Actions of intrahypothalamic interleukin‐6 compared to macrophage inflammatory protein‐1β (MIP‐1β)

Myers

Lopez-Valpuesta

Minñano

et al. 1994

J of Neuroscience Research

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The chemokines, macrophage inflammatory protein-1 (MIP-1) and its subunit MIP-1 beta, induce an intense fever in the rat when they are injected directly into the anterior hypothalamic, pre-optic area (AH/POA), a region containing thermosensitive neurons. The purpose of this study was to compare the central action on body temperature (Tb) of MIP-1 beta with that of interleukin-6 (IL-6), which also has been implicated in the cerebral mechanism underlying the pathogenesis of fever. Following the stereotaxic implantation in the AH/POA of guide cannulae for repeated micro-injections, radio transmitters which monitor Tb continuously were inserted intraperitoneally in each of 15 male Sprague-Dawley rats. Each micro-injection was made in a site in the AH/POA in a volume of 1.0 microliter of pyrogen-free artificial CSF, recombinant murine MIP-1 beta, or recombinant human IL-6. MIP-1 beta in a dose of 25 pg evoked an intense fever characterized by a short latency, a mean maximum rise in Tb of 2.4 +/- 0.21 degrees C reached by 3.7 +/- 0.42 hr, and a duration exceeding 6.5 hr. Injected into homologous sites in the AH/POA, IL-6 induced a dose dependent fever of similar latency and a mean maximal increase in Tb of 1.2 +/- 0.25 degrees C, 1.8 +/- 0.15 degrees C, and 2.1 +/- 0.22 degrees C and duration of 6.2 +/- 1.28 hr, 6.7 +/- 0.49 hr, and 6.8 +/- 0.65 hr when given in doses of 25, 50, and 100 ng, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Fever and feeding in the rat: Actions of intrahypothalamic interleukin‐6 compared to macrophage inflammatory protein‐1β (MIP‐1β)

Myers

Lopez-Valpuesta

Minñano

et al. 1994

J of Neuroscience Research

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“…Because calcium homeostasis can affect both the body temperature and immune function [6,28,29], mean total calcium in serum collected at 0, 2 and 4 DPP was compared among the groups. Total calcium was analyzed using atomic absorption spectrometry (AAnalyst 200; Perkin-Elmer Inc., Waltham, MA) as previously reported [6].…”

Section: Methodsmentioning

confidence: 99%

Uterine Microbiota and Immune Parameters Associated with Fever in Dairy Cows with Metritis

Jeon

Cunha

et al. 2016

PLoS ONE

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ObjectiveThis study aimed to evaluate bacterial and host factors causing a fever in cows with metritis. For that, we investigated uterine microbiota using a metagenomic sequencing of the 16S rRNA gene (Study 1), and immune response parameters (Study 2) in metritic cows with and without a fever.Principal Findings (Study1)Bacterial communities were similar between the MNoFever and MFever groups based on distance metrics of relative abundance of bacteria. Metritic cows showed a greater prevalence of Bacteroidetes, and Bacteroides and Porphyromonas were the largest contributors to that difference. A comparison of relative abundance at the species level pointed to Bacteroides pyogenes as a fever-related species which was significantly abundant in the MFever than the MNoFever and Healthy groups; however, absolute abundance of Bacteroides pyogenes determined by droplet digital PCR (ddPCR) was similar between MFever and MNoFever groups, but higher than the Healthy group. The same trend was observed in the total number of bacteria.Principal Findings (Study2)The activity of polymorphonuclear leukocyte (PMN) and the production of TNFα, PGE2 metabolite, and PGE2 were evaluated in serum, before disease onset, at 0 and 3 DPP. Cows in the MNoFever had decreased proportion of PMN undergoing phagocytosis and oxidative burst compared with the MFever. The low PMN activity in the MNoFever was coupled with the low production of TNFα, but similar PGE2 metabolite and circulating PGE2.Conclusion/SignificanceOur study is the first to show a similar microbiome between metritic cows with and without a fever, which indicates that the host response may be more important for fever development than the microbiome. Bacteroides pyogenes was identified as an important pathogen for the development of metritis but not fever. The decreased inflammatory response may explain the lack of a febrile response in the MNoFever group.

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“…Figure 3 shows also that the simultaneous application of the same concentration of both atropine and excess Ca++ ions within the same region of the rat's hypothalamus exacerbates the intensity in the decline of the animal's core temperature in terms of both magnitude and duration. Therefore, it is equally conceivable that cholinergic neurons serve to mediate the output of the physiological "set-point" mechanism, which is hypothesized to be controlled, in part, by cellular Ca++ ions within the posterior hypothalamus ( review of Myers, 1982).…”

Section: Receptor Characteristicsmentioning

confidence: 99%