The role of ion channels on the physiology of the neurovascular unit and the regulation of cerebral blood flow

Abstract

Journal of Cellular Neuroscience and Oxidative Stress is an online journal that publishes original research articles, reviews and short reviews on the molecular basis of biophysical, physiological and pharmacological processes that regulate cellular function, and the control or alteration of these processes by the action of receptors, neurotransmitters, second messengers, cation, anions, drugs or disease.Areas of particular interest are four topics. They are;A-Ion Channels (Na + -K + Channels, Clchannels, Ca 2+ channels, ADP-Ribose and metabolism of NAD + , Patch-Clamp applications) B-Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) C-Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD + on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson's and Alzheimer's diseases) D-Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)

Phenolic compounds can induce systemic and central immunomodulation, which result in a neuroprotective effect

“…Significant LPS‐induced activation of the pathway, which regulates pro‐inflammatory processes, was countered by a dose‐dependent SOCS‐1 activation (Porro et al, 2019). Thus, the authors propose a neuroprotective effect of the compound in microglial cells, a crucial component that contributes to regulating cerebral blood flow and other vital brain functions (Montiel‐Herrera et al, 2021). The role of curcumin on brain aging and overall health has been recognized by, among other effects, being a potent immunomodulatory molecule capable of exerting positive effects on this organ (Benameur, Soleti, Panaro, et al, 2021).…”

“…neuroprotective effect of the compound in microglial cells, a crucial component that contributes to regulating cerebral blood flow and other vital brain functions(Montiel-Herrera et al, 2021). The role of curcumin on brain aging and overall health has been recognized by, among other effects, being a potent immunomodulatory molecule capable of exerting positive effects on this organ(Benameur, Soleti, Panaro, et al, 2021).Zhang et al (2020) utilized a rat ischemia/reperfusion model, and administered intravenous salvianolic acid D treatments [phenolics from Danshen (Salvia miltiorrhiza)], at 1, 3 or 15 mg/kg) during reperfusion and 12 h after it.…”

La excitabilidad de las células gliales

“…Los Kv se componen de al menos doce subunidades (Kv1-12) y su expresión funcional en las células gliales comprende las corrientes de potasio con rectificación retardada (KDR) y tipo A (KA), que son sensibles al bloqueo farmacológico con tetraetilamonio y 4-aminopiridina. [52][53][54][55][56] En los astrocitos, las corrientes KDR presentan una mayor activación a voltajes positivos (despolarizantes) en comparación con los canales de potasio de rectificación entrante (Kir), que presentan mayor conductividad de K+ a voltajes más negativos (hiperpolarizantes). Las corrientes KA se registraron en cultivos primarios de astrocitos de rata utilizando un protocolo con un prepulso hiperpolarizante (-110 mV) seguido de pulsos de voltaje despolarizantes (de -70 a 50 mV).…”