The role of intralesional Pingyangmycin in the treatment of venous malformation of facial and maxillary region

Zhi, Kangkang; Wen, Yu-ming; Li, Longjiang; Ren, Wenhao

doi:10.1016/j.ijporl.2008.01.007

Cited by 40 publications

(40 citation statements)

References 8 publications

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“…Subjective evaluation by patients (excellent/good/fair/poor) found a ''good'' or ''excellent'' rating in 89%; complication of ulceration at the injection site occurred in only 1 patient, resulting in subsequent scarring. 6 Zhi et al 19 reported 82 patients with craniofacial VM treated by pingyangmycin injection: 81.7% had 76% to 100% regression, 14.6% had 51% to 75% regression, and 3 patients (3.7%) required surgical excision of their residual lesions. Minor complications of a 24-to 48-hour fever (3.7%) and local swelling lasting 1 to 2 weeks (6.1%) were noted but did not require treatment.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous treatment of facial venous malformations: A matched comparison of alcohol and bleomycin sclerotherapy

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Percutaneous treatment of facial venous malformations: A matched comparison of alcohol and bleomycin sclerotherapy

et al. 2011

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“…Moreover, although haemangiomas and vascular malformations are two pathologically separate entities, the diagnostic and therapeutic procedures used were identical, as were the healing phases after treatment (16,17). For these reasons, this paper generally refers to both haemangiomas and vascular malformations simply as vascular lesions.…”

Section: Discussionmentioning

confidence: 99%

Simple and Effective Cryosurgical Treatment of Various Oral Lesions

et al. 2014

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The objective of this study was to evaluate the efficacy of cryosurgery on 134 different benign oral lesions in 90 patients. All lesions were treated every 2 weeks until complete regression of the lesion had been achieved. Patients were examined at 2, 7, and 10 days, 2 and 4 weeks, and 3 and 6 months after the cryosurgery. The relationship between the number of cryosurgery applications to achieve complete regression and the type oflesions was assessed for statistical significance by one-way analysis of variance and with the Scheffe test. The mean application number of the cryosurgery was 1.82±0.49 for fibroma, 2.35±1.44 for vascular lesions, 1.50±0.70 for mucocele, 2.65±1.18 for lichen planus lesions. The difference between the type of the lesion and number of application was statistically significant for all groups (p< 0.05). Our data prove that a significantly fewer number of cryosurgery treatments are required to achieve complete regression for fibroma and mucocele lesions compared to lichen planus lesions. During the follow-up period, only 7 lichen planus lesions of 76 lesions recurred.

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“…The status of drainage in venous malformation provides important information for selection of different sclerosing agents: for low-drainage venous malformations, intralesional injection of Pinyangmycin (bleomycin A5) at a concentration of 1.5 to 2.0 mg/mL is sufficient to achieve the best results. 22 The maximum dose per injection of Pingyangmycin is 8 mg. The mechanism involves direct destruction of the endothelial cell, inflammatory reaction, formation of a thrombus and fibrosis leading to obstruction of the vessels, and shrinkage of the lesions.…”

Section: Treatment Of Venous Malformationsmentioning

confidence: 99%

Treatment guideline for hemangiomas and vascular malformations of the head and neck

et al. 2009

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Abstract:Vascular anomalies are among the most common congenital and neonatal dysmorphogenesis, which are separated into hemangiomas and vascular malformations. They can occur in various areas throughout the body, with 60% being located in the head and neck. The true mechanism of pathogenesis of vascular anomalies is still unclear. Various treatment methods have been reported, and there are still controversies over the selection of different treatment modalities. Based on the clinical and basic research and current literature, the Chinese Division of Oral and Maxillofacial Vascular Anomalies formulated a treatment guideline for hemangiomas and vascular malformations of the head and neck, which will be modified and updated periodically based on new medical evidence and research.

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The role of intralesional Pingyangmycin in the treatment of venous malformation of facial and maxillary region

Cited by 40 publications

References 8 publications

Percutaneous treatment of facial venous malformations: A matched comparison of alcohol and bleomycin sclerotherapy

Percutaneous treatment of facial venous malformations: A matched comparison of alcohol and bleomycin sclerotherapy

Simple and Effective Cryosurgical Treatment of Various Oral Lesions

Treatment guideline for hemangiomas and vascular malformations of the head and neck

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