Abstract:BACKGROUNDPsoriasis is a common immune-mediated chronic inflammatory disease of the
skin and joints, affecting 1-3% of the population. It is generally accepted
that the pathogenesis of psoriasis involves accumulation of effector T-cells
within lymph nodes and their subsequent migration into the skin through the
blood system. Here we provide evidence that psoriatic plaque itself may
serve as a source of inflammatory T-cells.OBJECTIVEWe examined the intradermal proliferation of T-cells and the number of
effector… Show more
“…70,[72][73][74] (3) The memory CD45RO + CLA À T cells are accompanied by the T h 1 and T h 17 cells to be carried out through the blood vessels from the dermis to the epidermis as the result of the intradermal proliferation of T-cells. 74 (4) In the epidermis, the natural killer T cells are responsible for direct antigen presentation due to their proximity to the keratinocytes. The activated T h 1 cells are stimulated by IL-18 and IL-23 to secrete interferon-gamma (IFN-g) cytokine.…”
Section: Pathogenesis Of Psoriasismentioning
confidence: 99%
“…(3) The memory CD45RO + CLA − T cells are accompanied by the T h 1 and T h 17 cells to be carried out through the blood vessels from the dermis to the epidermis as the result of the intradermal proliferation of T-cells. 74 …”
Lipid-based nanoparticles are lipidic nanocarriers that can encapsulate different antipsoriatic agents for topical uses, which enhance the alleviation process compared to conventional topical agents (without nanocarriers).
“…70,[72][73][74] (3) The memory CD45RO + CLA À T cells are accompanied by the T h 1 and T h 17 cells to be carried out through the blood vessels from the dermis to the epidermis as the result of the intradermal proliferation of T-cells. 74 (4) In the epidermis, the natural killer T cells are responsible for direct antigen presentation due to their proximity to the keratinocytes. The activated T h 1 cells are stimulated by IL-18 and IL-23 to secrete interferon-gamma (IFN-g) cytokine.…”
Section: Pathogenesis Of Psoriasismentioning
confidence: 99%
“…(3) The memory CD45RO + CLA − T cells are accompanied by the T h 1 and T h 17 cells to be carried out through the blood vessels from the dermis to the epidermis as the result of the intradermal proliferation of T-cells. 74 …”
Lipid-based nanoparticles are lipidic nanocarriers that can encapsulate different antipsoriatic agents for topical uses, which enhance the alleviation process compared to conventional topical agents (without nanocarriers).
“…Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation of keratinocytes mediated by the immune system. During this process, dendritic cells are activated, releasing pro-inflammatory factors, and then recruiting T cells to the skin lesions (17). Clinically, psoriasis vulgaris is the most common type.…”
Section: Curcumin Reduces Psoriasis-like Skin Lesions In Mice By Inhi...mentioning
As a chronic skin disease, psoriasis is a relatively common disease among various types of skin diseases. Because this disease is often distributed throughout the patient's body and is prone to develop, it is difficult to guarantee the quality of life and physical and mental health of patients with this disease. The purpose of this article is to investigate whether curcumin can effectively inhibit the NLRP3 inflammatory body and thereby reduce the inflammation in the mouse psoriasis model. Through the use of the curcumin gel prepared and the mouse psoriasis model, the percutaneous administration was used to investigate the mechanism and mechanism of curcumin's effect on reducing inflammation in the mouse psoriasis model. In addition, in order to better explore the curative effect of curcumin on psoriasis, related experiments were conducted by setting up a control group and an experimental group. The results show that curcumin has a good inhibitory effect on NLRP3 inflammatory bodies. Curcumin can not only reduce the NLRP3 expression and inhibit the inflammation caused by IL-22 and IL-18 but also reduce the damage of psoriasis. 22 Induced phosphorylation of STAT3 almost completely inhibits phosphorylation in normal cells. Among them, curcumin inhibited IL-22-induced phosphorylation of STAT3 up to 95.6%, and inhibited IL-22 and IL-18 by about 47%.
“…Врожденный иммунный ответ миндалин может играть решающую роль в инициации и последующем регулировании Т-клеточно-опосредованного адаптивного иммунного ответа. Таким образом, аномальные реакции миндалин на стрептококковую инфекцию могут привести к увеличению Т-клеток и воздействию их на кожу, где они индуцируют воспалительную реакцию, обостряющую псориатическое воспаление [14,[23][24][25]. Установлена роль β-гемолитического стрептококка как инфекционного агента, приводящего к возникновению каплевидного псориаза, наиболее часто встречающегося в педиатрической практике [12,14,24].…”
Статья посвящена современным представлениям о роли микробных агентов в патогенезе наиболее распространенных дерматозов в педиатрической практике. Показано значение микробиома кожи и очагов хронического воспаления в индукции и поддержании патологического процесса в дерме при атопическом дерматите, псориазе. Представлены собственные клинические наблюдения двух девочек в возрасте 12 лет с диагнозом: псориаз вульгарный с поражением кожи, волосистой части головы и в возрасте 5 лет с диагнозом: атопический дерматит, детская фаза, эритематозно-сквамозная форма, легкое течение. Препарат активированного цинка пиритиона обладает противовоспалительной, противогрибковой и противомикробной активностью, высоким профилем безопасности и может использоваться для контроля воспаления и коррекции микробиома кожи. Использование препарата активированного цинка пиритиона способствует существенному снижению необходимости применения наружных кортикостероидов. Ключевые слова: микробиом кожи, очаг хронической инфекции, псориаз, атопический дерматит, Malassezia, St. aureus, активированный цинк пиритион The role of infectious agents in the pathogenesis of dermatoses in children and adolescents
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