The role of intracytoplasmic sperm injection in non-male factor infertility in advanced maternal age

Tannus, Samer; Son, Weon‐Young; Gilman, Ashley; Younes, Grace; Shavit, Tal; Dahan, Michael H.

doi:10.1093/humrep/dew298

Cited by 79 publications

(77 citation statements)

References 23 publications

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“…To identify significant factors associated with outcomes of infertility treatments, we selected 10 pretreatment factors that have been investigated previously . These factors included the following: (i) ‘Advanced age’, defined as an age of 35 or older at the time each infertility treatment is initiated; (ii) ‘Secondary infertility’, defined as multiparous women with infertility; (iii) ‘Long infertility period’, defined as married patients who began infertility treatments after ≥24 months of unprotected and frequent intercourse; (iv) ‘Past treatment history’, defined as patients who were transferred from other hospitals; (v) ‘Decreased ovarian reserve’, defined as serum follicle‐stimulating hormone (FSH) levels greater than 10 mIU/ml in the early follicular phase; (vi) ‘Tubal infertility’, defined as obstructed fallopian tubes based on hysterosalpingography or hysteroscopy; (vii) ‘Male infertility’, defined as sperm abnormalities based on a semen analysis according to the World Health Organization criteria; (viii) ‘Uterine fibroid’, defined as a past history or current presence of uterine fibroid as judged by clinical images; (ix) the presence of ‘Advanced endometriosis;’ and (x) ‘Abdominal surgery history’.…”

Section: Methodsmentioning

confidence: 99%

The efficacy of non‐assisted reproductive technology treatment might be limited in infertile patients with advanced endometriosis in their 30s

Isono

Wada‐Hiraike

Akino

et al. 2018

J of Obstet and Gynaecol

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Aim: To determine the efficacious treatment for infertile couples, we assessed the impact of infertility factors including endometriosis on assisted reproductive technology (ART) and non-ART treatment, and the effect of age in infertility treatment outcomes was also investigated. Methods: The medical records of 1864 females, infertile patients from January 2000 to December 2015 at our hospital, were retrospectively reviewed under the approval of the Institutional Review Board. We extracted 10 representative factors and calculated the cumulative live birth rate (CLBR) in these patients. Multivariate analysis of ART and non-ART treatment was performed to assess the impact of infertility factors, and the age-related decline in cumulative live birth rate was calculated by creating eight agestratified subgroups. Results: In total, 21.9% and 49.4% of the patients conceived after being treated with non-ART and ART, respectively. Multivariate analysis revealed that age > 35, advanced endometriosis defined by the revised American Society for Reproductive Medicine classification system stages III to IV, and the past history or current presence of uterine fibroid had significantly negative impact on the outcome of non-ART. Age stratification revealed that advanced endometriosis adversely affected the outcome of non-ART, especially for patients in their 30s. Assisted reproductive technology treatment for patients with advanced endometriosis was shown to be efficacious because the negative impact had been diminished. Conclusion: Considering that non-ART treatment had limited role in patients with advanced endometriosis, prompt initiation of ART in these patients aged as young as 30 years can be recommended to achieve conception.

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Section: Methodsmentioning

confidence: 99%

The efficacy of non‐assisted reproductive technology treatment might be limited in infertile patients with advanced endometriosis in their 30s

Isono

Wada‐Hiraike

Akino

et al. 2018

J of Obstet and Gynaecol

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“…These data suggest that many clinics utilize ICSI for non-male factor indications, often at their own discretion (Chambers et al 2016). Some of these indications include unexplained infertility, low oocyte yield, advanced age and cryopreservation of embryos for fertility preservation (Palermo et al 2015, Tannus et al 2017.…”

Section: The Safety Of Icsimentioning

confidence: 99%

The safety of intracytoplasmic sperm injection and long-term outcomes

Pereira

O’Neill

et al. 2017

Reproduction

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The pioneering of intracytoplasmic sperm injection (ICSI) approximately 25 years ago revolutionized the treatment of infertile couples. Today, ICSI remains an indispensable part of assisted reproductive treatments (ART) and has resulted in the birth of millions of babies. The 25th anniversary of ICSI marks a chronologic landmark in its evolving history. This landmark also serves as an opportunity to thoroughly appraise the safety of ICSI and analyze the long-term outcomes of ICSI-conceived children. In this review, we collate and analyze salient data accrued over the past 25 years pertaining to the long-term safety of ICSI and ICSI conceptions. We also evaluate the effects of ICSI on the perinatal outcomes, congenital malformation rates, cognitive development and reproductive health of ICSI-conceived neonates, children, adolescents and adults, respectively. In doing so, we also highlight the existence of potential confounders and biases that frequently obscure the interpretation of clinical follow-up studies.Reproduction (2017) 154 F61-F70

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“…However, it is still imperative to analyze the trend of increasing ICSI utilization in nonmale factor settings, without any apparent benefits. In one recent study, the reproductive outcomes of 490 and 255 women >40 years of age undergoing ICSI and conventional IVF, respectively were compared (Tannus et al 2017). Despite similar numbers of total oocytes retrieved, the conventional IVF group had more mature oocytes.…”

Section: Application and Popularity Of Icsimentioning

confidence: 99%

The pioneering of intracytoplasmic sperm injection: historical perspectives

Rosenwaks

Pereira

2017

Reproduction

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Intracytoplasmic sperm injection (ICSI) has often been heralded as a ground-breaking technique that has transformed the treatment of couples with infertility. By injecting a single spermatozoon into the cytoplasm of the oocyte, ICSI bypasses the zona pellucida and increases the chances of fertilization and subsequent embryo development, independent of semen parameters. Ever since the first live births using ICSI were reported in 1992, ICSI has become the mainstay of treating male factor infertility as well as overcoming fertilization failure associated with conventional in vitro insemination. Today, ICSI is utilized in nearly 66% of all assisted reproductive treatments worldwide and has resulted in the birth of millions of babies. The primary goal of this review is to provide historical perspectives about the pioneering of ICSI. We begin by highlighting the scientific work of early investigators who elucidated the mechanisms central to mammalian fertilization. Furthermore, we briefly discuss how these findings contributed to the development of IVF for the treatment of infertility. We then emphasize the shortcomings of IVF in treating severe forms of male factor infertility and enumerate the micromanipulation techniques that were developed to circumvent these shortcomings. Finally, we indicate how the inadequacies of these micromanipulation techniques lead to the inception, application and popularity of ICSI.Reproduction (2017) 154 F71-F77

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The role of intracytoplasmic sperm injection in non-male factor infertility in advanced maternal age

Abstract: N/A.

Cited by 79 publications

References 23 publications

The efficacy of non‐assisted reproductive technology treatment might be limited in infertile patients with advanced endometriosis in their 30s

The efficacy of non‐assisted reproductive technology treatment might be limited in infertile patients with advanced endometriosis in their 30s

The safety of intracytoplasmic sperm injection and long-term outcomes

The pioneering of intracytoplasmic sperm injection: historical perspectives

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