The Role of Intracellular Acidosis in Muscle Fatigue

Allen, David G.; Westerblad, Håkan; Lännergren, Jan

doi:10.1007/978-1-4899-1016-5_5

Cited by 34 publications

(21 citation statements)

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“…20,37,39 Moreover, alterations in E-C coupling during fatigue may be induced by changes in intracellular energy supplies or metabolite accumulation. 2,15,35,40 Under our experimental conditions, several intracellular processes may have interacted to decrease muscle force in different ways in the two fatigue tests. The observation that the TR 1 ⁄2 of the twitch, which is known to be sensitive to pH changes, was increased during the CON test, but not during the ECC one, favors the hypothesis of a larger H + accumulation during CON contractions.…”

Section: Discussionmentioning

confidence: 93%

“…A decreased intracellular pH is known to inhibit Ca 2+ pumps and myofibrillar ATPase activities, leading to a reduced rate of Ca 2+ uptake by the sarcoplasmic reticulum and detachment rate of the crossbridges, consequently slowing muscle relaxation. 2,15 However, metabolic changes alone cannot explain the decrease in force during the two fatigue tests. In fact, a maximal torque deficit was still present after a 30-min rest period, a time during which metabolic changes should normally be restored.…”

Section: Discussionmentioning

confidence: 99%

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Muscle fatigue during concentric and eccentric contractions

et al. 2000

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Muscle fatigue during concentric and eccentric contractions

et al. 2000

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“…Low-frequency fatigue has been associated with impairments in E-C coupling, mainly due to reduction in the release of Ca 2+ from the sarcoplasmic reticulum (Bruton et al 1998). This phenomenon is more pronounced after eccentric than after concentric or isometric exercise, probably due to muscle damage induced by lengthening contractions (Allen et al 1995). …”

Section: Discussionmentioning

confidence: 99%

Eccentric exercise and delayed onset muscle soreness of the quadriceps induce adjustments in agonist–antagonist activity, which are dependent on the motor task

et al. 2011

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This study investigates the effects of eccentric exercise and delayed onset muscle soreness (DOMS) of the quadriceps on agonist–antagonist activity during a range of motor tasks. Ten healthy volunteers (age, mean ± SD, 24.9 ± 3.2 years) performed maximum voluntary contractions (MVC) and explosive isometric contractions of the knee extensors followed by isometric contractions at 2.5, 5, 10, 15, 20, and 30% MVC at baseline, immediately after and 24 h after eccentric exercise of the quadriceps. During each task, force of the knee extensors and surface EMG of the vasti and hamstrings muscles were recorded concurrently. Rate of force development (RFD) was computed from the explosive isometric contraction, and the coefficient of variation of the force (CoV) signal was estimated from the submaximal contractions. Twenty-four hours after exercise, the subjects rated their perceived pain intensity as 4.1 ± 1.2 (score out of 10). The maximum RFD and MVC of the knee extensors was reduced immediately post- and 24 h after eccentric exercise compared to baseline (average across both time points: 19.1 ± 17.1% and 11.9 ± 9.8% lower, respectively, P < 0.05). The CoV for force during the submaximal contractions was greater immediately after eccentric exercise (up to 66% higher than baseline, P < 0.001) and remained higher 24 h post-exercise during the presence of DOMS (P < 0.01). For the explosive and MVC tasks, the EMG amplitude of the vasti muscles decreased immediately after exercise and was accompanied by increased antagonist EMG for the explosive contraction only. On the contrary, reduced force steadiness was accompanied by a general increase in EMG amplitude of the vasti muscles and was accompanied by increased antagonist activity, but only at higher force levels (>15% MVC). This study shows that eccentric exercise and subsequent DOMS of the quadriceps reduce the maximal force, rate of force development and force steadiness of the knee extensors, and is accompanied by different adjustments of agonist and antagonist muscle activities.

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“…Due to a long time-lag (30-60 s) between shifts in activity between synergistic muscles and local blood circulation (Kouzaki et al, 2003), the shifts in activity between muscles needs to be of relatively long duration for generating shifts in local blood circulation between muscles. If ischemia and accumulation of metabolites are the main causes to local fatigue (Allen et al, 1995), also differential activation between regions within a single muscle may need to be of long duration for preventing local fatigue. Therefore, fatigue-preventing effects of differential activation may be restricted to low-level contractions in which differential activations of longer duration may occur.…”

Section: Introductionmentioning

confidence: 99%