The role of intestinal alkaline phosphatase in pediatric inflammatory bowel and celiac diseases

Molnár, Kálmán; Vannay, Ádám; Sziksz, Erna; Bánki, Nóra Fanni; Aron, C; Györffy, Hajnalka; Dezsőfi, Antal; Arató, András; Veres, Gábor

doi:10.1556/oh.2012.29441

Cited by 3 publications

(3 citation statements)

References 52 publications

(55 reference statements)

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“…In addition, significant positive correlations were determined between IAP and I‐FABP, IgE, IL‐4, IL‐13 ( p < 0.01), and eosinophils ( p < 0.05; Table 3 ). Similar to reports by many investigators in intestinal inflammations of various aetiologies (Goldberg et al., 2008 ; Kampanatkosol et al., 2014 ; Kühn et al., 2020 ; Molnar et al., 2012 ; Ok et al., 2020 ; I. B. Yildiz & Ok, 2022 ; R. Yildiz et al., 2018 ), our serum IAP levels were significantly increased in dogs with atopic dermatitis.…”

Section: Discussionsupporting

confidence: 90%

Investigation of the relationship between atopic dermatitis of dogs and intestinal epithelial damage

Ekici,

2024

Veterinary Medicine & Sci

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BackgroundA significant association between atopic dermatitis and leaky gut syndrome has been demonstrated in humans. No studies have been conducted to determine whether there is an association between atopic dermatitis and intestinal damage in dogs.ObjectivesThis study aimed to determine whether there is an association between canine atopic dermatitis and intestinal damage using selected intestinal‐related biomarkers.MethodsTwenty‐six dogs with atopic dermatitis and 10 healthy dogs were included. Moderate‐to‐severe pruritus, erythema, erosion and alopecia on different parts of the body were sought in dogs to suspect atopic dermatitis. The presence of atopic dermatitis was confirmed by an allergic skin test. Serum biomarkers including intestinal fatty acid binding protein (I‐FABP), intestinal alkaline phosphatase (IAP), trefoil factor‐3 (TFF‐3), immunoglobulin E (IgE), interleukin‐4 (IL‐4) and interleukin‐13 (IL‐13) concentrations were measured from venous blood samples.ResultsOf the 26 dogs tested for allergens, 16 were found to be sensitive to mould mites, 10 to vernal grass, eight to house dust mites, five to wheat dust and five to grass pollen mix allergens. Significant increases in serum IAP, TFF‐3, IgE, IL‐4 and IL‐13 concentrations were determined.ConclusionIt was thought that the increase in TFF‐3 and IAP concentrations may be due to the presence of intestinal epithelial damage and the repair of this damage. In addition, the development of atopic dermatitis may be predisposed to the entry of allergens into the body through sites of intestinal damage.

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Section: Discussionsupporting

confidence: 90%

Investigation of the relationship between atopic dermatitis of dogs and intestinal epithelial damage

Ekici,

2024

Veterinary Medicine & Sci

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“…Obesity is one of the chronic inflammatory conditions that have been linked to altered intestinal ALP expression (10). The results of our study showed decreased intestinal ALP activity in the overfed group.…”

Section: Discussionsupporting

confidence: 54%

“…Intestinal ALP is essential in the activation of bacterial Lipopolysaccharides (LPS) through dephosphorylation of its lipid A moiety, resulting in a non-toxic monophosphoryl section. This dephosphorylated monophosphoryl lipid A is not capable of forming a complex with the host's toll like receptor 4 (TLR4) (10).…”

Section: Gunduz Et Al Intestinal Effects Of Gingipainmentioning

confidence: 99%

Gingipain Injection Affects Intestinal OxidantAntioxidant Status and Alkaline Phosphatase in Overfed Zebrafish

Gündüz,

Beler,

Unal

et al. 2023

experimed

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Objective: Porphyromonas gingivalis (P. gingivalis), a major periodontopathogen, is associated with overfeeding disorders, including metabolic syndrome. Gingipains are one of the most powerful endotoxins of P. gingivalis. Our aim was to reveal the effects of gingipain injections on the intestinal oxidant-antioxidant status and alkaline phosphatase (ALP) activity in overfed zebrafish. Materials and Methods:Four groups of healthy adult zebrafish were placed in random tanks as C: Control (n=15); GP: Gingipain (n=15); OF: Overfeeding (n=15); and OF+GP: Overfeeding+Gingipain (n=15) groups. At the end of the experiment, levels of intestinal lipid peroxidation (LPO) and ALP, glutathione S-transferase (GST), and catalase (CAT) activities were evaluated. Results:Intestinal LPO was significantly lower in the GP and OF groups compared to C. Gingipain injection in OF (OF+GP) significantly elevated LPO when compared to C, GP, and OF groups. ALP activities decreased significantly in the GP, OF, and OF+GP compared to C. GST activities increased significantly in the GP when compared to C. Decreased GST activities were observed in the OF and OF+GP. This decrease was less in OF+GP. CAT activities significantly decreased in all groups when compared to C. Conclusion:Our findings demonstrate that gingipain injection alters the ALP activity and intestinal oxidant-antioxidant status in overfed zebrafish.

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Immune, inflammatory, autophagic and DNA damage responses to long-term H2O2 exposure in different tissues of common carp (Cyprinus carpio)

Jia

Cao

et al. 2021

Science of The Total Environment

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The role of intestinal alkaline phosphatase in pediatric inflammatory bowel and celiac diseases

Cited by 3 publications

References 52 publications

Investigation of the relationship between atopic dermatitis of dogs and intestinal epithelial damage

Investigation of the relationship between atopic dermatitis of dogs and intestinal epithelial damage

Gingipain Injection Affects Intestinal OxidantAntioxidant Status and Alkaline Phosphatase in Overfed Zebrafish

Immune, inflammatory, autophagic and DNA damage responses to long-term H2O2 exposure in different tissues of common carp (Cyprinus carpio)

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