The Role of Interleukin-17A (IL-17A) in Depression

Abstract

Context: The aim of this review was to address the recent data regarding the role of IL-17A in the pathogenesis of depression and its complications, such as cancer. Evidence Acquisition: This review article summarizes the recent data on the role of IL-17A in depression, using the PubMed and Google Scholar databases. Results: It has been documented that depression may alter the immune response via unknown mechanism/s. It is possible that immune responses and depression are linked via several molecules, including cytokines. IL-17A, a pro-inflammatory cytokine, participates in the pathogenesis of several inflammatory-based diseases, such as autoimmunity. Conclusions: Due to the comorbidity of depression and chronic inflammatory processes, and depression's effect on the immune system, it may be hypothesized that the IL-17A cytokine plays a key role in the pathogenesis of depression.

RAR‐related orphan receptor A: One gene with multiple functions related to migraine

“…Among these agents, cytokines and CD4 + T cells are considered to play an essential role in neurovascular inflammation 12 . Moreover, several findings suggested a sharp increase in plasma T‐helper 17 (Th17) cells, a member of three subsets of CD4 + T cells, and effector cytokines levels including IL‐4, IL‐5, IL‐6, IL‐10, and IL‐17A during neurovascular inflammation among migraine patients 13‐15 . Th17 cells secrete IL‐17 that induces chronic inflammatory disorders 16‐19 .…”