The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-<i>β</i> in Pregnancy Complicated by Placental Insufficiency

Darmochwał-Kolarz, Dorota; Michalak, Magdalena; Kolarz, Bogdan; Przegalinska-Kalamucka, Monika; Bojarska‐Junak, Agnieszka; Sliwa, Dariusz A.; Oleszczuk, Jan

doi:10.1155/2017/6904325

Cited by 41 publications

(34 citation statements)

References 34 publications

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“…On the other hand, pre-eclamptic women demonstrated an increased body mass index (BMI), percentage of caesarian section, systolic and diastolic blood pressure, WBC count, serum urea, and uric acid levels as compared to healthy controls. All these data are in accordance with the previous report [19]. Importantly, the glomerular ltration rate (GFR) was found to be signi cantly lower in subjects with PE as compared to healthy pregnant women.…”

Section: Discussionsupporting

confidence: 92%

Renalase levels and genetic variants are associated with preeclampsia: a hospital based study in Chinese cohort

Li¹,

Huang²,

2020

Preprint

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Background Pre-eclampsia (PE) is a major contributor of maternal and fetal morbidity and mortality. There are many host related biomolecules that regulate the pathophysiology PE. Critical analysis of these parameters is of crucial importance as some of these may be used as prognostic/diagnostic marker of this serious ailment and can be targeted for developing therapeutic measures against the disease. The aim of the current study is to examine the role of renalse in the context PE in a Chinese cohort. Methods A hospital based case control study was designed to investigate role of renalase in PE. 384 Chinese women consisting of subjects with normotensive pregnancy (n = 105), women with PE (n = 121) and healthy pregnancy (n = 158) were included in the study. Serum renalse level was measured in recruited subjects by ELISA. Renalase gene polymorphisms (rs10887800, rs2576178 and rs2296545) were genotyped by PCR-RFLP. Results A higher level of serum renalse in healthy pregnant women compared to controls, whereas, subjects with PE demonstrated a reduced level of this enzyme. Renalse level was negatively correlated with systolic as well as diastolic blood pressure, whereas, a positive association was observed with glomerular filtration rate. Prevalence of homozygous mutant (GG) and minor allele (G) of rs10887800 and rs2576178 polymorphisms were higher in PE patients compared to normotensive pregnant women and healthy controls. Furthermore, association of G-G-C haplotype with susceptibility to PE was observed. Conclusions Low level of renalse may be associated with high risk of PE during pregnancy. Renalase gene polymorphisms (rs10887800 and rs2576178) are correlated with with serum renalase and associated with predisposition to development of PE in Chinese cohort.

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Section: Discussionsupporting

confidence: 92%

Renalase levels and genetic variants are associated with preeclampsia: a hospital based study in Chinese cohort

Li¹,

Huang²,

2020

Preprint

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“…These results are contradictory to an earlier report (Poordast et al 2017) where a signi cantly lower level of this cytokine was demonstrated in pregnant groups (with and without PE) in comparison to healthy non-pregnant subjects. However, in line with our observations, a report by Darmochwal-Kolarz et al (Darmochwal-Kolarz et al 2017) also failed to demonstrate the difference of Il-23A among pregnant subjects with placental insu ciency (fetal growth restriction and PE) and healthy pregnant women. Our result showing a comparable level of IL-23 in subjects with PE and healthy pregnant women matched with the report, as mentioned above.…”

Section: Discussionsupporting

confidence: 91%

IL-17A Polymorphism (rs2275913) and Levels Are Associated With Preeclampsia Pathogenesis in Chinese Patients  

Lang

Liu

Hou

et al. 2020

Preprint

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BackgroundPreeclampsia (PE) is a pregnant related syndrome affecting both child and mother. Although, the role of various inflammatory molecules in PE has been demonstrated, importance of proinflammatory molecules such as IL-17A, IL-23 are poorly understood. In the present investigation, we tested a possible association of common genetic variants in IL-17A and IL-23 gene with PE. MethodsClinically diagnosed 115 PE patients who reported to the International Peace Maternity and Child Health Hospital were enrolled in the present study. Age, sex-matched 102 pregnant women, and 147 healthy Chinese women were also included. ELISA was used to quantify serum levels of IL-17A and IL-23 in all enrolled subjects. Common genetic polymorphisms in IL-17A (rs 2275913, rs1974226, and rs1974226), IL-23A (rs11171806), and IL-12B (rs3212227) were genotyped by PCR-RFLP or TaqMan probe-based method. ResultsElevated levels of serum IL-17A was observed in PE patients compared to pregnant (P<0.0001) and healthy women (P<0.0001). However, IL-23 levels were comparable among different clinical categories. Furthermore, heterozygous (GA) and minor allele (A) for IL-17A (rs2275913) and IL-23A (rs11171806) were more prevalent in PE patients in comparison to pregnant ladies or healthy women suggesting an essential role in predisposition to PE development. Interestingly, IL-17A (rs 2275913) mutants were linked with elevated IL-17A levels in comparison to wildtype (GG). ConclusionsIL-17A (rs2275913) variants are associated with higher serum levels of cytokine, and predisposed PE development.

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“…Recent studies have shown a significantly higher concentration of IL-17 in the serum of women with a pregnancy complicated by fetal growth restriction (FGR) and preeclampsia, compared to healthy pregnant women. In conjunction with a reduced TGF-β level detected in pregnancy complicated by FGR associated with preeclampsia (PE), it may induce an inflammatory response and, consequently, lead to placental insufficiency [67]. Perhaps the conducted research not only will allow us to understand the role of hormonal balance in the development of autoimmune diseases, but will also open up new opportunities for research on the impact of female sex hormones on the immune system in ovarian cancer [66].…”

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confidence: 99%

Th17 Cells and IL-17 As Novel Immune Targets in Ovarian Cancer Therapy

Bilska

Pawłowska

Zakrzewska³

et al. 2020

Journal of Oncology

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Ovarian cancer (OC) is usually diagnosed at an advanced stage and is related with poor prognosis. Despite numerous studies, the pathogenesis of OC is still unknown. Recent studies indicate the role of the immune system in the development and spread of OC. The identification of factors and mechanisms involved in that process and their modulation is crucial for creating effective antitumor therapy. We investigated the potential role of Th17 cells in OC patients (n = 71) by analyzing the frequencies of Th17 cells in three different environments, i.e., peripheral blood (PB), peritoneal fluid (PF), and tissue (Th17 infiltrating cells), and the concentration of IL-17A in plasma and PF of patients in terms of their clinical and prognostic significance. Th17 cells were analyzed by flow cytometry as a percentage of CD4+ lymphocytes that expressed intracellular expression of IL-17A. The level of IL-17A in plasma and PF were determined by ELISA. Our results showed accumulation of Th17 cells among tumor-infiltrating CD4+ lymphocytes (p<0.001 in relation to PB). Moreover, the percentage of Th17 cells in both PB and PF of OC patients was significantly lower than that in benign tumors group (n = 35). There were no significant differences in the percentage of Th17 cells in PB, PF, and tissue in relation to clinicopathological characteristics of OC patients and survival. The lower percentage of Th17 cells in the PB and PF of OC patients may promote evasion of host immune response by cancer cells. The concentration of IL-17A in plasma of OC patients was higher (p<0.0001) than that in both benign tumors and control group (n = 10). The PF IL-17A level in OC patients was higher (p<0.0001) than that in women with benign ovarian tumors, indicating its synthesis in OC microenvironment. Higher IL-17A level in PF is correlated with longer (median: 36.5 vs. 27 months) survival of OC patients.

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The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-β in Pregnancy Complicated by Placental Insufficiency

Cited by 41 publications

References 34 publications

Renalase levels and genetic variants are associated with preeclampsia: a hospital based study in Chinese cohort

Renalase levels and genetic variants are associated with preeclampsia: a hospital based study in Chinese cohort

IL-17A Polymorphism (rs2275913) and Levels Are Associated With Preeclampsia Pathogenesis in Chinese Patients

Th17 Cells and IL-17 As Novel Immune Targets in Ovarian Cancer Therapy

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The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-β in Pregnancy Complicated by Placental Insufficiency

Cited by 41 publications

References 34 publications

Renalase levels and genetic variants are associated with preeclampsia: a hospital based study in Chinese cohort

Renalase levels and genetic variants are associated with preeclampsia: a hospital based study in Chinese cohort

IL-17A Polymorphism (rs2275913) and Levels Are Associated With Preeclampsia Pathogenesis in Chinese Patients&nbsp;&nbsp;

Th17 Cells and IL-17 As Novel Immune Targets in Ovarian Cancer Therapy

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IL-17A Polymorphism (rs2275913) and Levels Are Associated With Preeclampsia Pathogenesis in Chinese Patients