The Role of Interleukin-10 in the Pathophysiology of Preeclampsia

Čubro, Hajrunisa; Kashyap, Sonu; Nath, Meryl C.; Ackerman, Allan W.; Garovic, Vesna D.

doi:10.1007/s11906-018-0833-7

Cited by 44 publications

(45 citation statements)

References 118 publications

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“…The use of either of these alone failed to recapitulate the extent of vascular dysfunction observed. This combination establishes the clinical fidelity of this model because IL-10 levels are reduced in clinical PE 5 . The relevance of these findings with respect to the clinical PE J o u r n a l P r e -p r o o f phenotype is further underscored by the effects of pregnancy on the severity of the phenotype: hypertension and albuminuria were the most severe in pregnant IL-10 -/mice injected with sPE sera; non-pregnant IL-10 -/mice injected with sPE sera behaved similarly to pregnant IL-10 -/mice injected with NT sera.…”

Section: J O U R N a L P R E -P R O O Fsupporting

confidence: 54%

“…However, their converging point seems to be systemic endothelial dysfunction, resulting in vascular injury, inflammation, and platelet activation. 5 The underlying molecular mechanisms are still poorly defined, despite recent advances in the understanding of the pathophysiological processes related to this disorder.…”

Section: Discussionmentioning

confidence: 99%

“…Second, decreased levels of IL-10 are identified in PE and PE-like syndromes. 5,[17][18][19] Third, IL-10 protects against endothelial dysfunction, a hallmark of vascular injury in PE. 20 Fourth, a seminal study that used pregnant IL-10 -/mice, showed that the mice injected with sera from PE patients 21 demonstrated classic signs of PE, including hypertension and albuminuria, along with glomerular endotheliosis, placental hypoxic injury, and increased anti-angiogenic factor levels, including fms-like tyrosine kinase receptor-1 (sFlt-1) and soluble endoglin (sEng).This model was further validated by experiments showing that hypoxia, which has long been implicated in the pathophysiology of PE, induced placental injury and increased placental expression and release of sFlt-1 and sEng, with a particularly severe phenotype in the absence of IL-10 22 .…”

Section: Discussionmentioning

confidence: 99%

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Mechanisms of vascular dysfunction in the interleukin-10–deficient murine model of preeclampsia indicate nitric oxide dysregulation

Čubro

Nath

Šuvakov

et al. 2021

Kidney International

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Section: J O U R N a L P R E -P R O O Fsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Mechanisms of vascular dysfunction in the interleukin-10–deficient murine model of preeclampsia indicate nitric oxide dysregulation

Čubro

Nath

Šuvakov

et al. 2021

Kidney International

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“…On the other hand, insufficient and/or inefficient remodeling of the maternal vascular bed in PE leads to placental ischemia, which promotes a chronic immune and redox imbalance, characterized by a reduced natural killer activity [14], and an increase of Th-1 response leading to an exacerbated inflammatory status [15,16]. This chronic inflammatory and hypoxic condition increase reactive oxygen species (ROS) and reactive nitrogen species (RNS) production such as O 2 -, OH, H 2 O 2 , NO, and ONOO -.…”

Section: Inflammation and Redox Imbalance In Preeclampsiamentioning

confidence: 99%

Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece?

Rozas-Villanueva

Casanello

Retamal

2020

IJMS

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Preeclampsia is a pregnancy complication that appears after 20 weeks of gestation and is characterized by hypertension and proteinuria, affecting both mother and offspring. The cellular and molecular mechanisms that cause the development of preeclampsia are poorly understood. An important feature of preeclampsia is an increase in oxygen and nitrogen derived free radicals (reactive oxygen species/reactive nitrogen species (ROS/RNS), which seem to be central players setting the development and progression of preeclampsia. Cell-to-cell communication may be disrupted as well. Connexins (Cxs), a family of transmembrane proteins that form hemichannels and gap junction channels (GJCs), are essential in paracrine and autocrine cell communication, allowing the movement of signaling molecules between cells as well as between the cytoplasm and the extracellular media. GJCs and hemichannels are fundamental for communication between endothelial and smooth muscle cells and, therefore, in the control of vascular contraction and relaxation. In systemic vasculature, the activity of GJCs and hemichannels is modulated by ROS and RNS. Cxs participate in the development of the placenta and are expressed in placental vasculature. However, it is unknown whether Cxs are modulated by ROS/RNS in the placenta, or whether this potential modulation contributes to the pathogenesis of preeclampsia. Our review addresses the possible role of Cxs in preeclampsia, and the plausible modulation of Cxs-formed channels by ROS and RNS. We suggest these factors may contribute to the development of preeclampsia.

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“…Excessive increase in inflammatory response in a pregnant woman's organism is not beneficial for her and may result in complications of her health. In some cases, higher concentrations of some inflammatory markers are associated with pregnancy complications such as: premature fetal membrane rupture, premature labor, hypertension, and preeclampsia, considered to be one of the most common causes of prematurity [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Association of Dietary Inflammatory Index with Serum IL-6, IL-10, and CRP Concentration during Pregnancy

et al. 2020

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Background: The mother’s diet has a direct impact on fetal development and pregnancy, and can also be important in the course of the body’s inflammatory response. An anti-inflammatory diet can be a promising way to counter an excessive inflammatory response in pregnancy. Objective: The aim of the study was to examine the association between the dietary inflammatory index (DII) and the pregnant women’s serum interleukin 6 (IL-6) and 10 (IL-10) and C-reactive protein (CRP) concentration in the course of normal and complicated pregnancy. Research Methods and Procedures: The study included 45 Polish pregnant women recruited to the study. The DII, a literature-based dietary index to assess the inflammatory properties of diet, was estimated based on a seven-day 24-h recall and an food frequency questionnaire (FFQ) in each trimester of pregnancy. At the same time as the nutritional interviews, blood samples were collected for the determination of IL-6, IL-10, and CRP concentrations. The studied group was divided into subgroups with normal and complicated pregnancy and depending on the DII median. Results: With the development of pregnancy, the DII score slightly decreased in subsequent trimesters: −1.78 in the first trimester, −2.43 in the second trimester, and −2.71 in the third trimester (p = 0.092). Independent of the trimester of pregnancy and the occurrence of pregnancy complications, the DII score did not affect the differences in the serum concentrations of IL-6, IL-10, and CRP, with the exception of CRP level in the second trimester in women with complicated pregnancy (subgroup with DII < median had a lower CRP level than subgroup with DII > median). In the first and third trimesters, there was a weak but significant positive correlation between the DII score and CRP concentration. During the second trimester, in the group with normal pregnancy and DII below the median, a significant negative correlation between the DII score and the serum IL-6 and IL-10 concentration was noted as well as in the third trimester for IL-6. Conclusion: The anti-inflammatory potential of a pregnant woman’s diet increases slightly with pregnancy development; however, its value has no permanent significant association with the level of CRP, IL-6, and IL-10.

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The Role of Interleukin-10 in the Pathophysiology of Preeclampsia

Cited by 44 publications

References 118 publications

Mechanisms of vascular dysfunction in the interleukin-10–deficient murine model of preeclampsia indicate nitric oxide dysregulation

Mechanisms of vascular dysfunction in the interleukin-10–deficient murine model of preeclampsia indicate nitric oxide dysregulation

Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece?

Association of Dietary Inflammatory Index with Serum IL-6, IL-10, and CRP Concentration during Pregnancy

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