Abstract:Drug addiction remains an unmanageable and costly disease. Apart from neuronal adaptation, growing recognition arises that glial proinflammatory activation importantly contributes to the rewarding effects of multiple drugs of abuse. Recent studies suggest the central importance of Toll‐like receptor 4 (TLR4), a candidate neuroimmune therapeutic target for drug addiction. While Interleukin‐1 receptor associated kinase 4 (IRAK4) plays a crucial role in TLR4 mediated innate immunity, there is no further studies s… Show more
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